The Korea Journal of Herbology (대한본초학회지)
- Volume 23 Issue 4
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- Pages.59-70
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- 2008
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- 1229-1765(pISSN)
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- 2288-7199(eISSN)
Antidepressant Effects of Citri Reticulatae Viride Pericarpium in the Forced Swimming Test
청피(靑皮)가 강제수영부하에 따른 우울행동에 미치는 영향
- Kwon, Yong-Uk (Dept. of Formulae Pharmacology, College of Oriental Medicine, Kyungwon University) ;
- Lee, Tae-Hee (Dept. of Formulae Pharmacology, College of Oriental Medicine, Kyungwon University)
- Published : 2008.12.30
Abstract
Objectives: Investigation of the antidepressant effects of Citri Reticulatae Viride Pericarpium(CR) Methods: In order to investigate the antidepressant effects of Citri Reticulatae Viride Pericarpium(CR), we performed the forced swimming test. Also the expression of CRF, HSP70 and c-fos was measured with immunohistochemical method at PVN. Results: 1. The duration of immobility in the forced swimming test was significantly decreased in the CR 100mg/kg, 400mg/kg groups. 2. In the Control group, CRF expression was significantly increased in the PVN. Also, these CRF increase were significantly reduced in the CR 100mg/kg and 400mg/kg treated group. 3. HSP70 expression was significantly decreased at PVN in the CR 100mg/kg and 400mg/kg treated group. 4. C-fos expression was significantly decreased at PVN in the CR 100mg/kg and 400mg/kg treated group. Conclusions: According to the results, it can be considered that Citri Reticulatae Viride Pericarpium has antidepressant effect.