Journal of Society of Preventive Korean Medicine (대한예방한의학회지)
- Volume 12 Issue 3
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- Pages.99-113
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- 2008
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- 1226-7066(pISSN)
The Effect to Drug Metabolizing Enzyme Cytochrome P450 3A4 by Chungyulyak
청열약 수종의 Cytochrome P450 3A4 효소활성도에 미치는 영향
- Jo, Hee-Chan (Dept. of Preventive Medicine, College of Oriental Medicine, Kyung Hee University) ;
- Shin, Yong-Cheol (Dept. of Preventive Medicine, College of Oriental Medicine, Kyung Hee University) ;
- Ko, Seong-Gyu (Dept. of Preventive Medicine, College of Oriental Medicine, Kyung Hee University)
- Published : 2008.12.31
Abstract
In this study, the author experimented the influence of five herbal medicines, which are Lonicera japonica Thunb, Paeonia suffruticosa Andr., Fraxinus rhynchophylla Hance, Gardenia jasminoides Ellis, Scutellaria baicalensis George which are called 'Chungyulyak(淸熱藥)' on drug metabolizing enzyme cytochrome P450 3A4 in Human Liver Microsome. Above all, the reason for this study is that herbal medicines can be assumed that herbs might have interactions with drugs, other herbs, alcohol and chemicals whether those are much better synergy effects than expected effects when the medicine was treated alone or not. As a result, we showed that all of five traditional herbal medicines had no CYP 3A4 inhibition effect on 10, 20, 30, 40,