The Korean Journal of Food And Nutrition (한국식품영양학회지)

The Korean Society of Food and Nutrition (한국식품영양학회)
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Characteristics of Antidiabetic Effect of Dioscorea rhizoma(2) - Prevention of Diabetic Neuropathy by NGF Induction -

산약의 항당뇨 특성 연구(2) - NGF 유도 신경병증예방 -

  • Kang, Tong-Ho (Dept. of Oriental Pharmaceutical Development, Nambu University) ;
  • Choi, Sang-Zin (R&D Center, Dong-A Pharm. Co, Ltd) ;
  • Lee, Tae-Ho (R&D Center, Dong-A Pharm. Co, Ltd) ;
  • Son, Mi-Won (R&D Center, Dong-A Pharm. Co, Ltd) ;
  • Park, Ji-Ho (East-West Medical Science Integrated Research Center, Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Kim, Sun-Yeou (East-West Medical Science Integrated Research Center, Graduate School of East-West Medical Science, Kyung Hee University)
  • Published : 2008.12.31
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Abstract

The main cause of diabetic neuropathy, one of the most debilitating complications, is the chronic hyperglycemia, the increase sorbitol or the decrease of nerve growth factor(NGF). NGF, a protein, plays a major role in the development and maintenance of peripheral nervous system. Systemic administration of NGF prevents manifestations of neuropathy in rodent models of diabetic neuropathy. In the previous investigation, we report the hypoglycemia effect of Dioscorea rhizoma extract(DRE) in diabetic mice. The present study shows protective effect of DRE on diabetic neuropathy by induction of NGF protein. We investigated the NGF level in salivary gland and sciatic nerve of normal mouse and the effect of DRE on sciatic nerve conductivity and thermal hyperalgesia test in Type 2 db/db mouse. DRE increased endogenous NGF level in salivary gland and sciatic nerve of mouse. And sensory nerve conductivity velocity(SNCV), motor nerve conductivity velocity(MNCV) and thermal hyperalgesia increased in DRE treatment mice compared with control group. On the basis of our results, we conclude that DRE increase induction of endogenous NGF level and have protective effect on diabetic neuropathy by induction of NGF. Therefore, we propose that long-term use of DRE might help prevention of diabetes-associated complication; diabetic neuropathy.

Keywords

References

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