Journal of Korean Biological Nursing Science
- Volume 10 Issue 1
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- Pages.88-95
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- 2008
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- 2383-6415(pISSN)
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- 2383-6423(eISSN)
Hindlimb Muscle Atrophy of Rat Induced by Neuropathic Pain
말초신경 손상에 의한 신경병증성 통증으로 유발된 쥐 뒷다리근 위축
- Choe, Myoung-Ae (College of Nursing, Seoul National University) ;
- Kim, Kyung-Hwa (College of Medicine, Seoul National University) ;
- An, Gyeong-Ju (Department of Nursing, Catholic University of Daegu) ;
- Lee, Kyung-Sook (Department of Nursing, Wonju Campus, Kangnung National University) ;
- Choi, Jung-An (Department of Nursing, Kkottongnae Hyundo University of Social Welfare)
- 최명애 (서울대학교 간호대학) ;
- 김경화 (서울대학교 대학원) ;
- 안경주 (대구 가톨릭대학교 간호학과) ;
- 이경숙 (강릉대학교 원주캠퍼스 간호학과) ;
- 최정안 (꽃동네 현도사회복지대학교 간호학과)
- Published : 2008.06.30
Abstract
Purpose: The purpose of this study was to examine the effect of neuropathic pain by peripheral nerve injury on mass and Type I and II fiber cross-sectional areas on hindlimb muscles of the neuropathic pain model rat. Method: Adult male Sprague-Dawley rats (body weight 200-220 g) were assigned to one of two groups: a neuropathic pain group (n=7) that had a ligation of the left L5 spinal nerve, a control group (n=5), a naive rat without any procedures. Withdrawal threshold, activity, body weight and food intake were measured daily. At 8 days after neuropathic pain, all rats were anesthetized and the soleus and plantaris muscles were dissected from the both hindlimbs. Body weight, food intake, muscle weight and Type I and II fiber cross-sectional area of the dissected muscles were determined. Result: The neuropathic pain group showed a significant decreases (p<.05) as compared with the control rats, in diet intake, body weight, muscle weight and Type II fiber cross-sectional area of the left (affected side) soleus and plantaris muscles, and the right (unaffected side) muscle weight of plantaris and Type II fiber cross-sectional area of the soleus muscle. Conclusion: The hindlimb muscle atrophy occurs in both affected and unaffected side due to neuropathic pain by the peripheral nerve injury. The hindlimb muscle atrophy of the affected side is more pronounced than that of the unaffected side.
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