Korean journal of dermatology (대한피부과학회지)

Korean Dermatological Association (대한피부과학회)
권호 표지

The Role of Indocyanine Green and Diode Laser in the Treatment of Acne Vulgaris

Indocyanine Green과 805 nm Diode Laser를 이용한 여드름 치료에 대한 유효성 평가

Lee, Doo-Rak;Park, Mi-Youn
이두락;박미연

  • Published : 2008.09.01
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Abstract

Background: Acne vulgaris is one of the most common dermatologic diseases and the main method of treatment is antibiotics and retinoids. However, many patients experience a need for a different treatment because of the transient effect and severe adverse effects. The study reported herein evaluated the effect and safety on acne vulgaris of 805 nm diode laser and topical Indocyanine green (ICG). Objective: To demonstrate the efficacy of the near-infrared diode laser phototherapy in combination with topical application of ICG in the treatment of acne vulgaris. Methods: Twenty-three volunteers with varying degrees of acne were enrolled in the study. Half of the face was stained by ICG. After 15 minutes, the whole face was irradiated by 805 nm diode laser. The procedure was carried out two times a week for 4 weeks. Inflammatory, non-inflammatory acne lesions were counted and sebum levels of both cheeks were measured. Results: The mean reduction of the inflammatory lesion counts was 43% in the ICG-diode laser group. The mean clearance of non-inflammatory lesions was 25% in the ICG-diode laser group. Significant reduction of acne lesions were observed in ICG-diode laser group compared to diode laser group (p＜0.05). The adverse effects were negligible on both sides of the face. Conclusion: ICG and diode laser therapy is effective in the treatment of moderate to severe acne vulgaris, and none of significant adverse effects were observed. (Korean J Dermatol 2008;46(9):1208∼1215)

Keywords

References

  1. Leyden JJ, McGinley KJ, Cavalieri S, Webster GF, Mills OH, Kligman AM. Propionibacterium acnes resistance to antibiotics in acne patients. J Am Acad Dermatol 1983;8: 41-45 https://doi.org/10.1016/S0190-9622(83)70005-8
  2. Eady EA, Jones CE, Tipper JL, Cove JH, Cunliffe WJ, Layton AM. Antibiotic resistant propionibacteria in acne: need for policies to modify antibiotic usage. BMJ 1993;306: 555-556 https://doi.org/10.1136/bmj.306.6877.555
  3. Papageorgiou P, Katsambas A, Chu A. Phototherapy with blue (415 nm) and red (660 nm) light in the treatment of acne vulgaris. Br J Dermatol 2000;142:973-978 https://doi.org/10.1046/j.1365-2133.2000.03481.x
  4. Abels C, Fickweiler S, Weiderer P, Baumler W, Hofstadter F, Landthaler M, et al. Indocyanine green (ICG) and laser irradiation induce photooxidation. Arch Dermatol Res 2000;292:404-411 https://doi.org/10.1007/s004030000147
  5. Itoh Y, Ninomiya Y, Tajima S, Ishibashi A. Photodynamic therapy of acne vulgaris with topical delta-aminolaevulinic acid and incoherent light in Japanese patients. Br J Dermatol 2001;144:575-579 https://doi.org/10.1046/j.1365-2133.2001.04086.x
  6. Nouri K, Villafradez-Diaz LM. Light/laser therapy in the treatment of acne vulgaris. J Cosmet Dermatol 2005;4:318- 320 https://doi.org/10.1111/j.1473-2165.2005.00213.x
  7. Bhardwaj SS, Rohrer TE, Arndt K. Lasers and light therapy for acne vulgaris. Semin Cutan Med Surg 2005;24:107-112
  8. Alexiades-Armenakas M. Laser-mediated photodynamic therapy. Clin Dermatol 2006;24:16-25 https://doi.org/10.1016/j.clindermatol.2005.10.027
  9. Nouri K, Ballard CJ. Laser therapy for acne. Clin Dermatol 2006;24:26-32 https://doi.org/10.1016/j.clindermatol.2005.10.020
  10. Abels C, Karrer S, Baumler W, Goetz AE, Landthaler M, Szeimies RM. Indocyanine green and laser light for the treatment of AIDS-associated cutaneous Kaposi's sarcoma. Br J Cancer 1998;77:1021-1024 https://doi.org/10.1038/bjc.1998.168
  11. Karrer S, Abels C, Baumler W, Steinbauer M, Landthaler M, Szeimies RM. Photochemotherapy with indocyanine green in cutaneous metastases of rectal carcinoma. Dtsch Med Wochenschr 1997;122:1111-1114 https://doi.org/10.1055/s-2008-1047735
  12. Lloyd JR, Mirkov M. Selective photothermolysis of the sebaceous glands for acne treatment. Lasers Surg Med 2002;31:115-120 https://doi.org/10.1002/lsm.10080
  13. Genina EA, Bashkatov AN, Sinichkin YP, Kochubey VI, Lakodina NA, Altshuler GB, et al. In vitro and in vivo study of dye diffusion into the human skin and hair follicles. J Biomed Opt 2002;7:471-477 https://doi.org/10.1117/1.1486247
  14. Tuchin VV, Genina EA, Bashkatov AN, Simonenko GV, Odoevskaya OD, Altshuler GB. A pilot study of ICG laser therapy of acne vulgaris: photodynamic and photothermolysis treatment. Lasers Surg Med 2003;33:296-310 https://doi.org/10.1002/lsm.10211
  15. Burton JL, Cunliffe WJ, Stafford I, Shuster S. The prevalence of acne vulgaris in adolescence. Br J Dermatol 1971;85:119-126 https://doi.org/10.1111/j.1365-2133.1971.tb07195.x
  16. Elman M, Lebzelter J. Light therapy in the treatment of acne vulgaris. Dermatol Surg 2004;30:139-146 https://doi.org/10.1111/j.1524-4725.2004.30053.x
  17. Kjeldstad B, Johnsson A. An action spectrum for blue and near ultraviolet inactivation of Propionibacterium acnes; with emphasis on a possible porphyrin photosensitization. Photochem Photobiol 1986;43:67-70 https://doi.org/10.1111/j.1751-1097.1986.tb05592.x
  18. Hongcharu W, Taylor CR, Chang Y, Aghassi D, Suthamjariya K, Anderson RR. Topical ALA-photodynamic therapy for the treatment of acne vulgaris. J Invest Dermatol 2000;115: 183-192 https://doi.org/10.1046/j.1523-1747.2000.00046.x
  19. Sigurdsson V, Knulst AC, van Weelden H. Phototherapy of acne vulgaris with visible light. Dermatology 1997;194:256- 260 https://doi.org/10.1159/000246114
  20. Cunliffe WJ, Goulden V. Phototherapy and acne vulgaris. Br J Dermatol 2000;142:855-856 https://doi.org/10.1046/j.1365-2133.2000.03528.x
  21. Wiegell SR, Wulf HC. Photodynamic therapy of acne vulgaris using 5-aminolevulinic acid versus methyl aminolevulinate. J Am Acad Dermatol 2006;54:647-651 https://doi.org/10.1016/j.jaad.2005.12.033
  22. Santos MA, Belo VG, Santos G. Effectiveness of photodynamic therapy with topical 5-aminolevulinic acid and intense pulsed light versus intense pulsed light alone in the treatment of acne vulgaris: comparative study. Dermatol Surg 2005;31:910-915 https://doi.org/10.1111/j.1524-4725.2005.31804
  23. Rojanamatin J, Choawawanich P. Treatment of inflammatory facial acne vulgaris with intense pulsed light and short contact of topical 5-aminolevulinic acid: a pilot study. Dermatol Surg 2006;32:991-997 https://doi.org/10.1111/j.1524-4725.2006.32221.x
  24. Fickweiler S, Szeimies RM, Baumler W, Steinbach P, Karrer S, Goetz AE, et al. Indocyanine green: intracellular uptake and phototherapeutic effects in vitro. J Photochem Photobiol B 1997;38:178-183 https://doi.org/10.1016/S1011-1344(96)07453-2