Journal of fish pathology (한국어병학회지)

The Korean Society of Fish Pathology (한국어병학회)
권호 표지

Pharmacokinetics of oxytetracycline in olive flounder (Paralichthys olivaceus) by dipping and oral administration

Oxytetracycline의 약욕 및 경구투여에 따른 넙치(Paralichthys olivaceus) 체내 약물동태학적 특성

  • Jung, Sung-Hee (Pathology Team, National Fisheries Research & Development Institute) ;
  • Choi, Dong-Lim (Pathology Team, National Fisheries Research & Development Institute) ;
  • Kim, Jin-Woo (Pathology Team, National Fisheries Research & Development Institute) ;
  • Jo, Mi-Ra (Food Safety Research Team, NFRDI) ;
  • Seo, Jung-Soo (Pathology Team, National Fisheries Research & Development Institute) ;
  • Jee, Bo-Young (Pathology Team, National Fisheries Research & Development Institute)
  • 정승희 (국립수산과학원 병리연구팀) ;
  • 최동림 (국립수산과학원 병리연구팀) ;
  • 김진우 (국립수산과학원 병리연구팀) ;
  • 조미라 (국립수산과학원 식품안전팀) ;
  • 서정수 (국립수산과학원 병리연구팀) ;
  • 지보영 (국립수산과학원 병리연구팀)
  • Published : 20080800
Download PDF
⟨ Previous Next ⟩

Abstract

The pharmacokinetic properties of oxytetracycline (OTC) were studied after dipping and oral administration to cultured olive flounder, Paralichthys olivaceus (600 g). Plasma concentrations of OTC were determined after oral dosage (50, 100 and 200 mg/kg body weight) and dipping (50, 100 and 200 ppm, 1 h) in olive flounder (average 600 g, 23±1℃). Plasma samples were taken at 3, 5, 10, 15, 24, 32, 48, 72, 120, 168 and 240 h post-dose. In oral dosage of 50, 100 and 200 mg/kg, the peak plasma concentrations of OTC, which attained at 3 h post-dose, were 0.34, 0.44 and 1.18 ㎍/㎖, respectively. In dipping of 50, 100 and 200 ppm, those of OTC which also observed at 5 h post-dose, were 0.43, 0.38 and 0.64 ㎍/㎖, respectively. Plasma concentrations of OTC were not measurable at 240 h post-dose in all experiments. The kinetic profile of absorption, distribution and elimination of OTC in plasma were analyzed fitting to a one-compartment model by WinNonlin program. The following parameters were calculated for a single dosage of 50, 100 and 200 mg/kg body weight, respectively: AUC (the area under the concentration-time curve)=31.40, 28.07 and 32.97 ㎍∙h/㎖; T1/2 (half-life)􀆫0.89, 1.12 and 0.43 h; Tmax (time for maximum concentration)= 5.25, 3.70 and 7.30 h, Cmax (maximum concentration)=0.25, 0.38 and 0.61 ㎕/㎖. Following dipping at 50, 100 and 200 ppm, these parameters were AUC􀆫15.51, 14.63 and 19.72 ㎍∙h/㎖; T1/2= 0.75, 0.41 and 0.74 h; Tmax=4.90, 7.08 and 4.68 h, Cmax=0.40, 0.32 and 0.46 ㎕/㎖.

Keywords

References

  1. Abedini, S., Namdari, R. and Law, F.C.P.: Comparative pharmacokinetics and bioavailability of oxytetracycline in rainbow trout and chinook salmon. Aquaculture, 162: 23-32, 1998 https://doi.org/10.1016/S0044-8486(97)00306-2
  2. Bjorklund, H. and Bylund, G.: Temperature-related absorption and excretion of oxytetracycline in rainbow trout (Salmo gairdneri R.). Aquaculture, 84: 363-372, 1990 https://doi.org/10.1016/0044-8486(90)90101-R
  3. Elema, M.O., Hoff, K.A. and Kristensen, H.G: Bioavailability of oxytetracycline from medicated feed administered to atlantic salmon (Salmo salar L.) in seawater. Aquaculture, 143: 7-14, 1996 https://doi.org/10.1016/0044-8486(96)01253-7
  4. Grondel, J.L., Nouws, J.F.M., DeJong, M., Schutte, A.R. and Driessens, F.: Pharmacokinetics and tissue distribution of oxytetracycline in carp, Cyprinus carpio L., following different routes of administration. J. of Fish Dis., 10: 153-163, 1987 https://doi.org/10.1111/j.1365-2761.1987.tb01057.x
  5. Namdari, R., Abedini, S. and Law, F.C.P.: A comparative tissue distribution study of oxytetracycline in rainbow trout, Oncorhynchus mykiss (Walbaum), and chinook salmon, Oncorhynchus tshawytscha (Walbaum). Aquacult. Res., 30: 279-286, 1999 https://doi.org/10.1046/j.1365-2109.1999.00329.x
  6. Nouws, J.F.M., Grondel, J.L., Boon, J.H. and VanGinneken, V.J.T.: Pharmacokinetics of antimicrobials in some fresh water fish species. In: Michel, C.M. and Aldeman, D.J. (eds). Office of International Epizootiology, Paris. 437-447, 1992
  7. Rigos, G., Alexis, M., Andriopoulou, A., and Nengas, I.: Pharmacokinetics and tissue distribution of oxytetracycline in sea bass, Dicentrarchus labrax, at two water temperatures. Aquaculture, 210: 59-67, 2002 https://doi.org/10.1016/S0044-8486(01)00868-7
  8. Rigos, G., Nengas, I., Tyrpenou, AE., Alexis, M. and Troisi, G.M.: Pharmacokinetics and bioavailability of oxytetracycline in gilthead sea bream (Sparus aurata) after a single dose. Aquaculture, 221: 75-83, 2003 https://doi.org/10.1016/S0044-8486(03)00071-1
  9. Rigos, G., Nengas, I., Alexis, M. and Athanassopoulor, F.: Bioavailability of oxytetracycline in sea bass, Dicentrarchus labrax (L). J. of Fish Dis., 27: 119-122, 2004 https://doi.org/10.1046/j.1365-2761.2003.00510.x
  10. Sangrungruang, K., chotchuang, A. and Ueno, R.: Comparative pharmacokinetics and bioavailability of oxytetracycline in giant tiger prawn. Fish. Sci., 70: 467-472, 2004 https://doi.org/10.1111/j.1444-2906.2004.00827.x
  11. Treves-Brown, K.M.: Applied fish pharmacology. Tetracyclines. pp.64-82. Kluwer Academic Publishers, Boston, London. 2000
  12. Ueno, R., Kinoshita, A. and Wakabayashi, J.: Comparative pharmacokinetics of oxytetracycline in eel and its fate in a closed aquatic environment. Aquaculture, 235: 53-63, 2004 https://doi.org/10.1016/S0044-8486(03)00449-6
  13. Uno, K.: Pharmacokinetic study of oxytetracycline in health and vibriosis- infected ayu (Plecoglossus altivelis). Aquaculture, 143: 33-42, 1996 https://doi.org/10.1016/0044-8486(95)01225-7
  14. Uno, K., Aoki, T. and Ueno, R.: Pharmacokinetic study of oxytetracycline in cultured rainbow trout, amago salmon and yellowtail. Nippon Suisan Gakkaishi., 58: 1151-1156, 1992 https://doi.org/10.2331/suisan.58.1151
  15. Uno, K., Aoki, T., Ueno, R. and Maeda, I.: Pharmacokinetics of oxytetracycline in rainbow trout Oncorhynchus mykiss following bolus intravenous administration. Fish. Sci.. 63:90-93, 1997 https://doi.org/10.2331/fishsci.63.90
  16. Zhang, Q. and Li, X.: Pharmacokinetics and residue elimination of oxytetracycline in grass carp, Ctenopharyngodon idellus. Aquaculture, 272: 140-145, 2007 https://doi.org/10.1016/j.aquaculture.2007.08.033
  17. 김석, 정희식, 강석중, 하지영, 정원철, 허성혁, 신용운, 김경원, 김대근, 이후장: Oxytetracycline과 tetracycline의 약욕에 따른 양식어류 (넙치, 조피볼락, 참돔)의 조직내잔류량의변화. 한국어병학회지, 19: 155-164, 2006
  18. 국립수의과학검역원 고시 제2007-25호: 동물용의 약품의안전사용기준. 2008
  19. 이장락: 동물약품해설, 서울대학교출판부. pp. 220-224, 1994
  20. 이희정, 이태식, 손광태, 김풍호, 조미라, 박미정, 이영호: HPLC를 이용한 어패류 중의 테트라사이클린계 항생제 분석방법 개발. 한국수산학회지, 38: 372-378, 2005 https://doi.org/10.5657/kfas.2005.38.6.372
  21. 정준기, 김진우, 박관하, 강소영, 김형락, 강주찬, 박남규, 정승희, 서정수, 백근욱, 이상환, 김나영, 박음미, 김수연, 이민섭, 민은영, 고혜진, 제주은: 양식장 항생제 저감관리방안 및 기생충 구제제의 환경영향에 관한 연구용역. 농림수산식품부. 2008
  22. 정승희, 김진우: 넙치 근육중 잔류 옥시테트라싸이클린의 간이스크리닝 검출방법 비교연구. 한국어병학회지, 11: 77-81, 1998
  23. 정승희, 김진우: 병용항균제의 어류질병 세균에 대한 시험관내 항균활성. 한국어병학회지, 13:45-51, 2000
  24. 한국동물약품협회: 동물용의약품등편람. 2001