한국여성 유방암의 개인별 발생위험도 예측

Estimation of Individualized Probabilities of Developing Breast Cancer for Korean Women

김선호;채영수;손원준;신동준;김유미;장명철
Kim, Sun-Ho;Chae, Young-Su;Son, Won-Jun;Shin, Dong-Jun;Kim, You-Me;Chang, Myung-Chul

  • 발행 : 20080600

초록

Purpose: Based on the results of the relative risk model of Korean breast cancer, the aim of this study was to develop a Korean breast cancer risk assessment tool which would display the absolute breast cancer risks of Korean women. Methods: The tool was developed in the three steps: selection of risk factors and relative risks, calculation of baseline breast cancer incidences, and estimation of absolute breast cancer risks. The risk factors used in this tool were age, family history of first- and second-degree relatives, body mass index, age at first delivery, history of breast-feeding, and a special test on the breasts. A program was developed in an HTML file, which was used for input of the risk factors, and a CGI file, which was used to calculate the risk and display the results. Results: The program was stored in the Internet web page, http://home.dankook.ac.kr/breast/brca/brca.htm. After receiving an input of risk factors, the program was able to calculate the relative risk compared to all the age groups, the estimated absolute risks following 5 and 10 years, and the estimated absolute risks up to ages 64 and 74 years. The estimated risks of Korean women using this tool were less than those reported by the NCI risk assessment tool. The risk of breast cancer was highest in the fifth decade. Conclusion: In this study, we developed a web page containing a Korean breast cancer risk assessment tool. This program may be useful for the assessment of individual breast cancer risks, the selection of screening tools, and the evaluation of preventive options for risk reduction. (J Korean Surg Soc 2008;74:405-411)

키워드

참고문헌

  1. Euhus DM. Understanding mathematical models for breast cancer risk assessment and counseling. Breast J 2001;7:224-32. https://doi.org/10.1046/j.1524-4741.2001.20012.x
  2. Ministry of Health & Walfare, Korean Central Cancer Registry, Korean Regional Cancer Registry (Korea). Cancer Incidence in Korea 1999-2001. Gwachon, Korea: Ministry of Health & Walfare; 2005.
  3. Gail MH, Brinton LA, Byar DP, Corle DK, Green SB, Schairer C, et al. Projecting individualized probabilities of developing breast cancer for white females who are being examined annually. J Natl Cancer Inst 1989;81:1879-86. https://doi.org/10.1093/jnci/81.24.1879
  4. Dunn BK, Ford LG. From adjuvant therapy to breast cancer prevention: BCPT and STAR. Breast J 2001;7:144-57. https://doi.org/10.1046/j.1524-4741.2001.007003144.x
  5. Park SK, Yoo KY, Kang DH, Ahn SH, Noh DY, Choe KJ. The estimation of breast cancer disease-probability by difference of individual susceptibility. Cancer Res Treat 2003;35:35-51. https://doi.org/10.4143/crt.2003.35.1.35
  6. Chang MC. Estimating relative risk of breast cancer in Korean women using computer program. J Korean Breast Cancer Soc 2004;7:294-8. https://doi.org/10.4048/jkbcs.2004.7.4.294
  7. Korea National Statistical Office, Korean Statistical Information System. Statistics of deaths by cause. http://kosis.nso. go.kr/.
  8. Choi YH, Kim YJ, Noh DY, Yoo KY. Prediction of future occurrence and probability of developing breast cancer over lifespan in Korean women. J Korean Breast Cancer Soc 2005;8:80-5. https://doi.org/10.4048/jbc.2005.8.3.80
  9. Ahn SH, You C, Lee DS, Han W, Choe KJ, Noh DY. Determining the main risk factors and high-risk groups of breast cancer using a predictive model for breast cancer risk assessment in South Korea. Cancer Nurs 2004;27:400-6.
  10. Jee SH, Song JW, Nam CM. Development of the individualized health risk appraisal model of breast cancer risk in Korean women. Korean J Epidemiol 2004;26:50-8.
  11. Claus EB, Risch N, Thompson WD. Autosomal dominant inheritance of early-onset breast cancer. Implications for risk prediction. Cancer 1994;73:643-51. https://doi.org/10.1002/1097-0142(19940201)73:3<643::AID-CNCR2820730323>3.0.CO;2-5
  12. Berry DA, Parmigiani G, Sanchez J, Schildkraut J, Winer E. Probability of carrying a mutation of breast-ovarian cancer gene BRCA1 based on family history. J Natl Cancer Inst 1997;89:227-38. https://doi.org/10.1093/jnci/89.3.227
  13. Slattery ML, Kerber RA. A comprehensive evaluation of family history and breast cancer risk. The Utah Population Database. JAMA 1993;270:1563-8. https://doi.org/10.1001/jama.270.13.1563
  14. McTiernan A. Behavioral risk factors in breast cancer: can risk be modified? Oncologist 2003;8:326-34. https://doi.org/10.1634/theoncologist.8-4-326
  15. Prentice RL, Caan B, Chlebowski RT, Patterson R, Kuller LH, Ockene JK, et al. Low-fat dietary pattern and risk of invasive breast cancer: the Women's Health Initiative Randomized Controlled Dietary Modification Trial. JAMA 2006;295:629-42. https://doi.org/10.1001/jama.295.6.629
  16. Kerlikowske K, Grady D, Rubin SM, Sandrock C, Ernster VL. Efficacy of screening mammography. A meta-analysis. JAMA 1995;273:149-54. https://doi.org/10.1001/jama.273.2.149
  17. Kerlikowske K, Grady D, Barclay J, Sickles EA, Eaton A, Ernster V. Positive predictive value of screening mammography by age and family history of breast cancer. JAMA 1993; 270:2444-50. https://doi.org/10.1001/jama.270.20.2444
  18. Gail M, Rimer B. Risk-based recommendations for mammographic screening for women in their forties. J Clin Oncol 1998;16:3105-14. https://doi.org/10.1200/JCO.1998.16.9.3105
  19. Vogel VG, Costantino JP, Wickerham DL, Cronin WM, Cecchini RS, Atkins JN, et al. Effects of tamoxifen vs raloxifene on the risk of developing invasive breast cancer and other disease outcomes: the NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 trial. JAMA 2006;295:2727-41. https://doi.org/10.1001/jama.295.23.joc60074
  20. Cuzick J. Aromatase inhibitors in prevention--data from the ATAC (arimidex, tamoxifen alone or in combination) trial and the design of IBIS-II (the second International Breast Cancer Intervention Study). Recent Results Cancer Res 2003;163:96-103.
  21. Brown P. Risk assessment: controversies and management of moderate- to high-risk individuals. Breast J 2005;11:S11-9. https://doi.org/10.1111/j.1075-122X.2005.217163.x
  22. Armstrong K, Eisen A, Weber B. Assessing the risk of breast cancer. N Engl J Med 2000;342:564-71. https://doi.org/10.1056/NEJM200002243420807
  23. Hartmann LC, Schaid DJ, Woods JE, Crotty TP, Myers JL, Arnold PG, et al. Efficacy of bilateral prophylactic mastectomy in women with a family history of breast cancer. N Engl J Med 1999;340:77-84. https://doi.org/10.1056/NEJM199901143400201