Journal of The Korean Ophthalmological Society (대한안과학회지)

The Korean Ophthalmological Society (대한안과학회)
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Efficacy of Vitamin A-containing Lubricant in Dry Eye Syndrome Evaluated by Impression Cytology

건성안에서 결막 압흔세포검사를 이용한 비타민 A 함유 누액의 치료효과의 평가

Kim, Eun-Chul;Joo, Choun-Ki
김은철;주천기

  • Published : 2008.11.01
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Abstract

Purpose: To evaluate the therapeutic effect of topical vitamin A-containing lubricant in dry eye patients. Methods: Three hundred eyes of 150 patients with dry eye (Schirmer I test≤10 mm, BUT≤10 seconds) were divided into three groups. Preservative-containing artificial tears, preservative-free artificial tears, and vitamin A-containing lubricant were administrated to Groups 1, 2, and 3, respectively (N=50). We evaluated and checked symptom scores, tear film breakup time (tBUT), Schirmer I test results, corneal fluorescein stain scores, and impression cytology immediately and at 1, 2, and 3 months after treatment. Results: Mean tBUT and goblet cell density significantly increased from 5.06±1.25 to 6.76±1.21 sec and from 125.62±61.52 to 192.86±69.38 cell/mm2, respectively, after 2 months in group 3 (P<0.05). Impression cytology grade significantly decreased from 2.14±0.38 to 1.67±0.41 after 2 months in group 3 (P<0.05). The Schirmer I test score significantly increased from 9.12±4.15 to 12.83±0.96 mm, and the corneal stain score decreased from 2.13±0.95 to 1.18±0.68 after 3 months in group 3 (P<0.05). Conclusions: The improvement of symptoms and the stabilization of tear films and ocular surfaces suggested that treatment with vitamin A-containing lubricant for dry eye was effective.

목적: 건성안에서 vitamin A함유 누액의 효과를 알아보았다. 대상과 방법: Schirmer I 10 mm 이하, tBUT 10초 이내의 건성안 환자 150명 300안 중 1군은 보존제 인공누액(50명), 2군은 무 보존제 인공누액(50명), 3군은 vitamin A함유 누액(50명)으로 나누어 사용전, 사용후 1, 2, 3달에 각각 증상, tBUT, Schirmer I test, 형광염색 각막 검사, 결막압흔세포 검사하였다. 결과: 3군에서 사용전과 사용 후 2개월의 tBUT는 5.06±1.25, 6.76±1.21초로, 술잔세포의 밀도도 125.62± 61.52, 192.86±69.38 cell/mm2로 유의하게 증가했고, 결막압흔세포 등급은 2.14±0.38, 1.67±0.41로 유의하게 감소했다(P<0.05). 사용전과 사용 후 3개월의 Schirmer I은 9.12±4.15, 12.83±0.96 mm로 유의하게 증가했고, 각막상피병증의 정도는 2.13±0.95, 1.18±0.68로 유의하게 감소했다(P<0.05). 결론: vitamin A 함유 누액은 안구건조증상을 완화시키고 눈물막과 안구표면을 안정시키므로 안구건조증에 효과적이라 생각된다.

Keywords

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