Annals of Laboratory Medicine

Korean Society for Laboratory Medicine (대한진단검사의학회)
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Incidence of Aspirin Resistance in the Patient Group of a University Hospital in Korea

한국의 한 대학병원 환자에서의 아스피린 저항성의 빈도

Lee, Young-Kyung;Kim, Han-Sung;Park, Ji-Young;Kang, Hee-Jung
이영경;김한성;박지영;강희정

  • Published : 2008.12.28
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Abstract

Background : Aspirin is the most common drug used for the prevention of arterial thrombosis. However, platelet responsiveness to aspirin is variable among individuals and it is important to detect aspirin resistance to improve clinical outcome. We analyzed the changes of platelet reactivity before and after aspirin treatment. We also investigated the incidence and influencing factors of aspirin resistance in Korean. Methods : We tested platelet function in 198 patients who had been treated with aspirin in a Korean university hospital, and 59 of these patients were tested for platelet function before and after aspirin treatment. We also analyzed platelet reactivity in 136 patients who had not been treated with aspirin. Platelet function was tested using the VerifyNow Aspirin Assay (Accumetrics, USA). Platelet reactivity was expressed as aspirin reaction unit (ARU) and ≥550 ARU was defined as aspirin resistance. Results : Platelet reactivity of 136 patients who had not been treated with aspirin was 632.2±46.3 ARU (mean±SD) (range, 462-675). Platelet reactivity of 198 patients who had been treated with aspirin was 472.5±60.0 (338-666) ARU, and 10.1% of patients were aspirin-resistant. The difference of platelet reactivity before and after aspirin treatment was 128.3±68.7 (-40-248) ARU. Hb level was lower and platelet count was higher in aspirin-resistant group than in aspirin-sensitive group (P<0.05). Conclusions : We demonstrated the distribution of platelet reactivity before and after aspirin treatment using the VerifyNow Aspirin Assay. The incidence of aspirin resistance was 10.1%, and low Hb level and high platelet count were related with aspirin resistance. (Korean J Lab Med 2008;28:251-7)

Keywords

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