Clinical Analysis of Successfully Treated Amblyopia with Anisometropia, Strabismis, and Combined Cause

약시 치료에 성공한 굴절부등약시, 사시약시, 혼합약시의 임상분석

Kim, Eun-Kyung;Choi, Mi-Young;Kim, Yeon-Hui
김은경;최미영;김연희

  • Published : 2008.02.01

Abstract

Purpose: To evaluate the duration of therapy in amblyopic children with anisometropia and/or strabismus who had been successfully treated with a best corrected visual acuity (BCVA) of 1.0. Methods: The duration of amblyopic treatment was compared according to the cause of amblyopia (anisometropia, strabismus, combined), the initial BCVA of amblyopic eye, the age at treatment, and the prediction of a further duration of treatment needed. Results: The mean age of amblyopic treatment in 66 amblyopic children with anisometropia and strabismus was 5.4 years and the mean duration of treatment to gain BCVA of 1.0 was 15.9 months. The duration of treatment was longer in children with initially poorer BCVA and in younger aged children than in older aged children at diagnosis. However, there was no statistical significance according to the cause of amblyopia. In occlusion therapy, the patching time from the initial BCVA to 1.0 was not statistically different from the patching time from the midpoint VA (between the initial visual acuity and 1.0) to 1.0. Conclusions: The duration of treatment to gain a VA of 1.0 was dependent on the degree of the initial BCVA in the amblyopic eye and the age at treatment. In occlusion therapy, the duration of further treatment to gain a BCVA of 1.0 was necessary as much as the duration to gain a midpoint VA from the initial BCVA.

목적 : 굴절부등과 사시에 의한 약시 환아 중 약시 치료 후 최대교정시력이 1.0으로 회복된 경우를 대상으로 약시 치료의 기간을 예측할 수 있는 인자를 알아보고자 하였다. 대상과 방법 : 약시 치료에 성공한 환아에서 약시 원인(굴절부등, 사시, 혼합), 나쁜 눈의 초진 시 최대교정시력, 약시 치료를 시작한 나이에 따른 치료 기간을 비교하였으며, 약시 치료 중 남은 치료 기간을 예측할 수 있는지를 알아보았다. 결과 : 굴절부등과 사시에 의한 약시 66명의 약시 치료 시 나이는 평균 5.4세이었으며, 평균 15.9개월 후 최대교정시력이 1.0으로 호전되었다. 약시 치료 기간은 치료 시작 시 나쁜 눈의 최대교정시력이 나쁠수록, 나이가 어릴수록 길어졌으나, 약시 원인에 따른 통계학적 차이는 없었다. 가림치료만을 시행한 경우, 최대교정시력이 초기시력과 1.0의 중간시력까지 호전되는 동안 가림시간은 이후 1.0이 될 때까지의 가림시간과 통계학적 차이가 없었다. 결론 : 약시 치료 시작 시 나쁜 눈의 최대교정시력과 나이에 따라 치료 기간이 달랐다. 가림치료 후 초기 최대교정시력과 1.0의 중간시력까지 도달한 경우 1.0이 되려면 그만큼의 가림시간이 더 필요하였다.

Keywords

References

  1. von Noorden GK. Binocular Vision and Ocular Motility, 6th ed. St. Louis: C.V. Mosby, 2002;246
  2. Tommila V, Tarkkanen A. Incidence of loss of vision in the healthy eye in amblyopia. Br J Ophthalmol 1981;65:575-7 https://doi.org/10.1136/bjo.65.8.575
  3. Woodruff G, Hiscox F, Thompson JR, Smith LK. Factors affecting the outcome of children treated for amblyopia. Eye 1994;8:627-31 https://doi.org/10.1038/eye.1994.157
  4. Oh DE, Lim KH. Efficacy of occlusion therapy in amblyopia : type, depth and timing of amblyopia. J Korean Ophthalmol Soc 2003;44:2850-6
  5. Lithander J, Sjostrand J. Anisometropic and strabismic amblyopia in the age group 2 years and above: a prospective study of the results of treatment. Br J Ophthalmol 1991;75:111-6 https://doi.org/10.1136/bjo.75.2.111
  6. Pediatric Eye Disease Investigator Group. A comparison of atropine and patching treatments for moderate amblyopia by patient age, cause of amblyopia, depth of amblyopia, and other factors. Ophthalmology 2003;110:1632-8 https://doi.org/10.1016/S0161-6420(03)00500-1
  7. Beardsell R, Clarke S, Hill M. Outcome of occlusion treatment for amblyopia. J Pediatr Ophthalmol Strabismus 1999;36:19-24
  8. Romano PE, Romano JA, Puklin JE. Stereoacuity development in children with normal binocular single vision. Am J Ophthalmol 1975;79:966-71 https://doi.org/10.1016/0002-9394(75)90679-0
  9. Flynn JT, Woodruff G, Thompson JR, et al. The therapy of amblyopia : an analysis comparing the results of amblyopia therapy utilizing two pooled data sets. Trans Am Ophthalmol Soc 1999;97:373-90
  10. Hiscox F, Strong N, Thompson JR, et al. Occlusion for amblyopia : a comprehensive survey of outcome. Eye 1992;6:300-4 https://doi.org/10.1038/eye.1992.59
  11. Holmes JM, Kraker RT, Beck RW, et al. Pediatric Eye Disease Investigator Group. A randomized trial of prescribed patching regimens for treatment of severe amblyopia in children. Ophthalmology 2003;110:2075-87 https://doi.org/10.1016/j.ophtha.2003.08.001
  12. Mintz-Hittner HA, Fernandez KM. Successful amblyopia therapy initiated after age 7 years: compliance cures. Arch Ophthalmol 2000;118:1535-41 https://doi.org/10.1001/archopht.118.11.1535
  13. Kim IS, Cho YA. Therapy of strabismic amblyopia less than 0.1 vision. J Korean Ophthalmol Soc 1995;36:338-43
  14. Levy NS, Glick EB. Stereoscopic perception and Snellen visual acuity. Am J Ophthalmol 1974;78:722-4 https://doi.org/10.1016/S0002-9394(14)76312-3
  15. Burian HM. Stereopsis. Doc Ophthalmol 1951;5-6:169-83 https://doi.org/10.1007/BF00143660
  16. Lee SY, Isenberg SJ. The relationship between stereopsis and visual acuity after occlusion therapy for amblyopia. Ophthalmology 2003;110:2088-92 https://doi.org/10.1016/S0161-6420(03)00865-0
  17. Sen DK. Results of treatment of anisohypermetropic amblyopia without strabismus. Br J Ophthalmol 1982;66:680-4 https://doi.org/10.1136/bjo.66.10.680
  18. Weakley DR Jr. The association between nonstrabismic anisometropia, amblyopia, and subnormal binocularity. Ophthalmology 2001;108:163-71 https://doi.org/10.1016/S0161-6420(00)00425-5
  19. Chung JK, Choi KS, Park SH. Qualitative assessment of binocular and monocular visual function in successfully treated amblyopes. J Korean Ophthalmol Soc 2006;47:947-53