Exercise Science (운동과학)

korean Society of Exercise Physiology (한국운동생리학회)
권호 표지

Effect of power walking program on the Immune response in human body

Power Walking 프로그램이 인체의 면역 반응에 미치는 영향

Choi, H.G.
최혜진

  • Published : 2008.03.01
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Abstract

Choi, Hea-Gin. Effect of Power Walking Program on the Immune Response in Human Body. Exercise Science, 17(1): 1-10, 2008. The purpose of this study was to investigate the effects of power walking program on the immune response including interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), c-reactive protein (CRP), white blood cell (WBC) in female adults. 31 healthy female adults aged 19 to 22 years were participated in this study and classified as a three groups by light walking group (30-60 HRmax, 3-5d/wk, 30-55min/d), power walking group (40-70 HRmax, 3-5d/wk, 30-55min/d), and control group (non exercise program). They performed power walking program on treadmill for 12 months. IL-6, TNF-α, CRP, WBC were measured before treatment, after 6 months, and 12 months of the program treatment. Cardiorespiratory fitness were indirectly assessed by Harvard 5-minute step test. Repeated Measured Analysis of Variance (ANOVA), Multiple Range Test (Bonferroni), Pearson Product-Moment Correlation, Analysis of Simple Linear Regression, and Dubin Watson Test were used to examine the statistical significance using SPSS 12.0 windows (SPSS Inc., Chicago, Ilinois). There were significant differences on TNF-α for 12 months among three groups and walking period (p<.05), but there were no significant differences on IL-6, CRP, and WBC among three groups. Cardiorespiratory fitness was associated with IL-6 (r=0.39, p<.05). In conclusion, power walking program for 12 months may be partly affected on immune response in healthy female adults.

최혜진. 파워워킹 프로그램이 인체의 면역 반응에 미치는 영향. 운동과학, 제17권 제1호. 1-10, 2008. * 이 연구는 2005년도 정부(교육인적자원부)의 재원으로 한국학술진흥재단의 지원을 받아 수행된 연구임 KRF-2005-037-G00045본 연구의 목적은본 연구는 12개월간 파워워킹을 실시하여 운동 전과 운동 6개월, 운동 12개월 후의 면역 변인들의 변화와 심폐지구력을 분석하여 효과적인 운동프로그램 구축을 위한 실험적인 자료를 제공하는데 목적이 있다. 31명의 건강한 젊은 여성(19~22세)이 연구에 참여하였고, 완전임의배열법에 의하여 3집단으로 분류되었다. 소량 걷기집단(n=10), 파워워킹집단(n=10), 통제집단(n=11)으로 분류되어 집단별로 12개월간 파워워킹 프로그램을 실시하였다. 파워워킹 프로그램은 트레드밀에서 실시하였고, 집단별로 매주 속도, 경사각도, 빈도, 시간 등을 점증적으로 증가시켰다. 운동전, 6개월, 12개월 후에 각각 면역세포를 측정하였다. Interleukin-6(IL-6), tumor necrosis factor-α(TNF-α), c-reactive protein(CRP), white blood cell은 침전 후에 분석되었고, 심폐지구력은 5분 하버드 스텝테스트를 이용하여 간접적으로 측정하였다. 반복측정 일원변량분산분석, Bonferroni test, Pearson Product-Moment 상관분석, 단순회귀분석, Dubin Watson test 등을 이용하여 통계적 절차가 수행되었다. 건강한 여성들에게 있어서 12 개월간의 파워워킹은 TNF-α를 기간에 따라 집단에 따라 통계적으로 유의한 차가 있는 것으로 나타났고(p<.05), IL-6, CRP, WBC에 통계적으로 유의한 차가 나타나지 않았다. 건강한 성인 여성들에게 있어서 심폐지구력은 TNF-α에 유의한 영향을 미치는 것으로 나타났다(p<.05). 결론적으로, 건강한 여성들에게 12개월간 파워워킹은 인체의 면역반응에 부분적으로 긍정적인 영향을 미친다고 볼 수 있다.

Keywords

References

  1. Adamopoulos, S., Parissis, J., Karatzas, D., Kroupis, C., Georgiadis, M., & Karavolias, G.(2002). Physical training modulates proinflammatory cytokines and the soluble Fas/soluble Fas ligand system in patients with chronic heart failure. J. Am. Coll. Cardiol., 39: 653-663. https://doi.org/10.1016/S0735-1097(01)01795-8
  2. Albert, M. A., Glynn, R. J., & Ridker, P. M.(2004). Effect of physical activity on serum C-reactive protein. Am. J. Cardiol., 93: 221 - 225. https://doi.org/10.1016/j.amjcard.2003.09.046
  3. Alf, L. L., Aukrust, P., Aarsland, T., & Dickstein, K.(2001). Effects of aerobic exercise training on plasma levels of tumor necrosis factor-a in patients with heart failure. Am. J. Cardiol., 88: 805-808. https://doi.org/10.1016/S0002-9149(01)01859-8
  4. Baecke, J. A., Burema, J., & Frijters, J. E.(1982). A short questionnaire for the measurement of habitual physical activity in epidemiological studies. Am. J. Clin. Nutr., 36: 936-42. https://doi.org/10.1093/ajcn/36.5.936
  5. Clakson, P. M.(1995). Antioxidants and physical performance. Crit. Rev. Food Nutr., 35(12): 131-141. https://doi.org/10.1080/10408399509527692
  6. Claman, H.(1972). Corticosteroids and lymphoid cells. Int J. Sports Med., 287: 338-397.
  7. Davison, R. C. R., Grant, S., Mutrie, N., Nash, A., & Kelly, M. P. T.(1991). Walk for health? Journal of Sports Science, 10: 556.
  8. De Servi, S., Ricevuti, G., Mazzone, A., Ghio, S., Zito, A., & Raffaghello, S.(1991). Granulocyte function in coronary artery disease. Am. J. Cardiol., 68: 64-68. https://doi.org/10.1016/0002-9149(91)90262-J
  9. Drenth, J. P., Krebber, R. J., Bijzet, J., & Van Der Meer, J. W.(1998). Increased circulating cytokine receptors and ex vivo interleukin-1 receptor antagonist and interleukin -I beta production but decreased tumour necrosis factor alpha production after a 5-km run. Eur. J. Clin. Invest., 28: 866-872. https://doi.org/10.1046/j.1365-2362.1998.00366.x
  10. Duncan, J. J., Gordon, N. F., & Scott, C. B.(1991). Women walking for health and fitness. How much enough? Journal of the American Medical Association, 266: 3291-3299.
  11. Espersen, G. T., Elbaek, A., Schmidt-Olsen, S., Ejlersen, E., Varming, K., & Grunnet, N.(1996). Short-term changes in the immune system of elite swimmers under competition conditions. Different immunomodulation induced by various types of sport. Scand. J. Med. Sci. Sports., 6: 156-163.
  12. Feldmann, M., Brennan, F. M., & Maini, R. N.(1996). Role of cytokine in rheumatoid arthritis. Annu. Rev. Immunol., 14:397-440. https://doi.org/10.1146/annurev.immunol.14.1.397
  13. Flynn, T. W., & Soutas-little, R. W.(1993). Mechanical power and muscle action during forward and backward running. J. Orthop. Sports Phys. Ther., 17: 108-112. https://doi.org/10.2519/jospt.1993.17.2.108
  14. Folsom, A. R., Wu, K. K., Rosamond, W. D., Sharrett, A. R., & Chambless, L. E.(1997). Prospective study of hemostatic factors and incidence of coronary heart disease: the Atherosclerosis Risk in Communities(ARIC) Study. Circulation, 96: 1102-1108. https://doi.org/10.1161/01.CIR.96.4.1102
  15. Ford, E. S.(2002). Does exercise reduce inflammation? Physical activity and C-reactive protein among U.S. adults. Epidemiology, 13(5): 561 - 568. https://doi.org/10.1097/00001648-200209000-00012
  16. Fried, S. K., Bunkin, D. A., & Greenberg, A. S.(1998). Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. J. clin. Endocrinol. Metab., 83: 847. https://doi.org/10.1210/jc.83.3.847
  17. Gabay, C., & Kushner, I.(1999). Acute-phase proteins and other systemic responses to inflammation. N. Engl. J. Med., 340: 448-454. https://doi.org/10.1056/NEJM199902113400607
  18. Gabriel, H., Schwartz, L., Born, P., & Kindermun, W.(1991). Differential mobilization of leukocyte and lymphocyte subpopulations into the circulation during endurance exercise. Eur. J. Appl. Physiol., 65: 529. https://doi.org/10.1007/BF00602360
  19. Geffken, D. F., Cushman, M., Burke, G. L., Polak, J. F., Sakkinen, P. A., & Tracy, R. P.(2001). Association between physical activity and markers of inflammation in a healthy elderly population. Am. J. Epidemiol., 153(3): 242 - 250. https://doi.org/10.1093/aje/153.3.242
  20. Gielen, S., Adams, V., Mobius-Winkler, S., Linke, A., Erbs, S., & Yu, J.(2003). Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure. J. Am. Coll. Cardiol., 42: 861-868. https://doi.org/10.1016/S0735-1097(03)00848-9
  21. Goldhammera, E., Tanchilevitcha, A., Maorb, I., Beniaminia, Y., Rosenscheina, U., & Sagiv, M.(2005). Exercise training modulates cytokines activity in coronary heart disease patients. Inter. J. Cardiol., 100: 93-99. https://doi.org/10.1016/j.ijcard.2004.08.073
  22. Heyward, V. H.(1998). Advanced Fitness Assessment, and Exercise Prescription. Champaign, IL: Human Kinetics.
  23. Hoffman-Goetz, L., & Pedersen, B. K.(1994). Exercise and the immune system: a model of the stress response? Immunol., Today, 15: 382-387. https://doi.org/10.1016/0167-5699(94)90177-5
  24. Juhan-Vague, I., Thompson, S., & Jespersen, J.(1997). Involvement of the hemostatic system in the insulin resistance syndrome: a study of 1500 patients with angina pectoris. The ECAT Angina Pectoris Study Group. Arterioscler. Thromb., 13: 1865-1873.
  25. Katja, B., Tuna, L., Veikko, S., & Pekka, J.(2005). Associations of leisure time physical activity, self-rated physical fitness, and estimated aerobic fitness with serum C-reactive protein among 3803 adults. Atherosclerosis, 23.
  26. Kim, D. J., .Noh, J. H., Lee, B. W., Choi, Y. H., & Jung, J. H.(2005). A white blood cell count in the normal concentration range is independently related to cardiorespiratory fitness in apparently healthy Korean men. Metabolism Clinical and Experimental, 54: 1448-1452. https://doi.org/10.1016/j.metabol.2005.05.009
  27. Lee, C. D., Folsom, A. R., & Nieto, F. J.(2001). White blood cell count and incidence of coronary heart disease and ischemic strike and mortality from cardiovascular disease in African-American and white men and women: atherosclerosis risk in communities study. Am. J. Epidemiol., 154: 758-764. https://doi.org/10.1093/aje/154.8.758
  28. Madden, K., & Felten, D. L.(1995). Experimental basis for neural-immune interactions. Physiol. Rev., 75: 77-106. https://doi.org/10.1152/physrev.1995.75.1.77
  29. Mattusch, F., Dufaux, B., & Heine, O.(2000). Reduction of the plasma concentration of C-reactive protein following nine months of endurance training. Int. J. Sports Med., 21: 21-24. https://doi.org/10.1055/s-2000-8852
  30. Nicklas, B. J., Ambrosius, W., Messier, S. P., Miller, G. D., Penninx, B. W., Loeser, J. H., Palla, R. F., Bleecker, E., & Pahor, M.(2004). Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: a randomized controlled clinical trial. American Journal of Clinical Nutrition, 79: 544-551. https://doi.org/10.1093/ajcn/79.4.544
  31. Nieman, D. C.(1997). Exercise immunology: Practical applications. Int. J. Sports Med., 18:S91-S100. https://doi.org/10.1055/s-2007-972705
  32. Nieman, D. C., Buckley, K. S., Henson, D. A., Warren, B. J., Suttles, J., Ahle, J. C., Simandle, S., Fagoaga, O. R., & Nehlsen-Cannarella, S. L.(1995). Immune function in marathon runners versus sedentary controls. Med. Sci. Sports Exercise, 27: 986-992. https://doi.org/10.1249/00005768-199507000-00006
  33. Otha, T., Kawamura, T., Hatano, K., Yokoi, M., & Uozumi, Z.(1990). Effects of exercise on coronary risk factors in obese, middle-aged subject. Japanese circulation Journal, 1459-1464.
  34. Pedersen, B. K., & Hoffmann-Goetz, L.(2000). Exercise and the immune system: Regulation, integration and adaption. Physiol. Rev., 80: 1055-1081. https://doi.org/10.1152/physrev.2000.80.3.1055
  35. Pedersen, B. K, Adam, S., & Peter, S.(2001). Exercise and interleukin-6. Curr. Opin. Hematol., 8, 137-141. https://doi.org/10.1097/00062752-200105000-00002
  36. Pedersen, B. K, Ostrowski, K, Rohde, T., & Bruunsgaard, H.(1998). Nutrition, exercise and the immune system. Proc. Nutr. Soc., 57: 43-47.
  37. Rawson, E. S., Freedson, P. S., Osganian, S. K, Matthews, C. E., Reed, G., & Ockene, I. S.(2003). Body Mass Index, but Not Physical Activity, Is Associated with C-Reactive Protein. Med. Sci. Sports. Exerc., 35: 1160-1166. https://doi.org/10.1249/01.MSS.0000074565.79230.AB
  38. Shephard, R. J., Thomas, S., & Weller, I. (1991). The canadian home fitness test-1991 update. Sports Medicine, 11(6) : 358-366. https://doi.org/10.2165/00007256-199111060-00002
  39. Smith, J. K., Dykes, R., Douglas, J. E., Krishnaswamy, G., & Berk, S.(1999). Long-term exercise and atherogenic activity of blood mononuclear cells in persons at risk of developing ischemic heart disease. JAMA, 281: 1722 - 1727. https://doi.org/10.1001/jama.281.18.1722
  40. Terlikowski, S. J.(2002). Local immunotherapy with TNF--alpha mutein induces strong antitumor activity without overt toxicity. Toxicology, 174:143-152. https://doi.org/10.1016/S0300-483X(02)00010-0
  41. Tracy, R., Psaty, B., & Macy, E.(1997). Lifetime smoking exposure affects the association of C-reactive protein with cardiovascular disease risk factors and subclinical disease in healthy elderly subjects. Arterioscler. Thromb. Vasc. Biol., 17: 2167 - 2176. https://doi.org/10.1161/01.ATV.17.10.2167
  42. Willoughby, D. S., McFarlin, B., & Bois, C.(2003). Interleukin-6 Expression After Repeated Bouts of Eccentric Exercise. International Journal of Sports Medicine, 15-21.
  43. Wilmore, J. H., Royce, J., Girandola, R. N., Katch, F. I., & Katch, V. L.(1970). Physiological alterations resulting from a 10-week program of jogging. Med. Sci. Sports, 2: 7-14.
  44. Yudkin, J. S.(1999). Abnormalities of coagulation and fibrinolysis in insulin resistance. Diabetes Care, 22: C25-30.