Journal of the Korean Society of International Agriculture (한국국제농업개발학회지)

The Korean Society of International Agriculture (한국국제농업개발학회)
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Bioactive Constituents and Utilities of Ganghwayakssuk (Artemisia princeps Pamp.)

강화약쑥의 생리활성 물질과 이용

Ryu, Su-Noh
류수노

  • Published : 2008.12.01
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Abstract

The Artemisia which is widely distributed with many and various among the Asteraceae, is currently reported existing about 400 different species. These are mainly distributed over the Northern hemi-sphere comprising Asisa, Europe, North America. The Ganghwayakssuk is divided into two classes such as the Sajabalssuk and the Ssajuarissuk. These two classes are indistinguishable from each other with general characteristics beside leaves. Moreover, the characteristics of leaves also show continuous variation based on two types. As a result of analysis on the morphological characteristics and the principle component of leaves, the Sajabalssuk has been reported as another type of the Ssajuarissuk. There are many medicinal constituents identified from the Genus Artemisia, for example, flavonoids, such as eupatilin, jaceosidin, eupafolin, apigenin, hispidulin etc., phenylpropanoids such as 9-hydroxyeugenol, sesamin, ursolic acid etc., and triterpenoids such as wrightial, wrightial acetate, ursolic acid, amyrin acetate, cycloartanol etc. It is identified that alcohol extracts of the Ganghwayakssuk have effect on improving symptoms type II diabetes, hyperlipidemia, hypertention etc. In addition, with regarding to anti-cancer activities, the Artemisia induced apoptosis and reduced nephrotoxicity that is induced by the medication of anti-cancer drug. Alcohol extracts of the Ganghwayakssuk also are known to have effects on inhibiting obesity and improving liver function and atopicallergy via the antiinflammatory and anti-allergic efficacy. Accordingly, there are many potentials to develop health care foods, medicines, cosmedicals etc. with the Ganghwayakssuk, as it contains various constituents showing medicinal activities.

쑥속(Genus Artemisia)은 국화과(Asteraceae, Compositae)의 식물속 중 가장 종류가 많고 널리 분포하는 속으로 현재까지 약 400여종이 알려져 있다. 이들은 아시아, 유럽, 북미 등 주 로 북반구에 분포하고 있다. 강화약쑥(Ganghwayakssuk)에는 사자발쑥(Sajabalssuk) 계열과 싸주아리쑥(Ssajuarissuk) 계열이 있다. 두 계열은 잎 이외의 다른 형질에서는 구별이 어렵고, 잎의 형질도 두가지 형을 중심으로 연속변이를 보인다. 잎의 형태형질(morphological characteristics)과 주성분 분석(principle component analysis) 결과 싸주아리쑥의 또다른 형이 사자발쑥 인 것으로 보고되어 있다. 약쑥에서 분리한 flavonoid 성분에는 eupatilin, jaceosidin, eupafolin, apigenin, hispidulin 등이 밝혀져 있고, phenylpropanoid 성분에는 9-hydroxyeugenol, sesamin, ursolic acid 등 이 밝혀졌다. 또한 triterpenoid 성분에는 wrightial, wrightial acetate, ursolic acid, amyrin acetate, cycloartanol 등의 구조 가 밝혀졌다. 강화약쑥 알코올 추출물은 제2형 당뇨병증상 개 선효과와 고지혈증, 고혈압의 증상을 개선하는 효과 등이 밝 혀졌다. 그리고 항암활성과 관련하여 apoptosis를 유도하였으 며, 항암제 투여에 의한 신장독성을 경감시켰다. 또한 강화약 쑥 알코올 추출물은 비만억제효과, 간기능 개선효과와 항염증 및 항알러지효능을 통한 아토피증상 개선효과 등이 알려져 있다. 이와 같이 강화약쑥은 다양한 약리활성을 나타내는 성분을 가지고 있기 때문에 강화약쑥을 이용한 건강기능성식품, 의약 품, 기능성향장품 등의 개발가능성이 클 것으로 보인다.

Keywords

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