Journal of Korean Academy of Oral Health

The Korean Academy of Preventive Dentistry and Oral Health (대한예방치과·구강보건학회)
권호 표지

Influence of smoking in modified experimental gingivitis model

실험치은염모형에서 흡연의 영향

Hwang, Soo-Jeong;Kim, Nam-Hui;Kim, Hyeon-Deok;Baek, Dae-Il
황수정;김남희;김현덕;백대일

  • Published : 2008.12.01
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Abstract

Objectives : The objectives of this study were to measure the influence of smoking in modified experimental gingivitis model and find out the partial mechanism of gingivitis in smokers. Methods : We used the modified experimental gingivitis model with toothshield. 67 male volunteers pariticipating this study by a written consent. They brushed twice a day putting on toothshield filled with each dentifrice for premolar region. The gingivitis index (GI), plaque index (PI), the concentration of MMP-9 and IL-1β in GCF were evaluated at the baseline, 1st, 2nd, 3rd, 5th week (recovery period) in toothshield sites. Repeated measure ANOVA and one-way ANOVA were used for the time series comparison and the comparison among the groups in SPSS 12.0K. Results :1. The differences of GI and PI among smokers, quit -smokers and non-smokers were not significant (p>0.05), but, the trend of GI was different among 3 groups. 2. The concentrations of MMP-9 and IL-1β in GCF were different significantly among 3 groups (P<0.05). The differences between smokers and non-smokers or among 3 groups were significant in Tukey analysis. Conclusions : Although we could not inspect the clinical change in gingiva, the concentration of MMP-9 and IL-1β increased significantly in smokers. It is suggested smoking can hide the inflammation sign at first glance, but progress the inflammation process in gingival tissue.

Keywords

References

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