Journal of the Korean Society of Radiology (대한영상의학회지)

The Korean Society of Radiology (대한영상의학회)
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Serial Correlation between the Ultrasonographic and Pathologic Findings of Intramuscular Hemorrhaging in an Experimental Rabbit

실험토끼에서 근육내출혈의 시간경과에 따른 초음파소견과 병리소견의 연관성

Ko, Kyung-Ran;Ryu, Kyung-Nam;Park, Ji-Seon;Jin, Wook;Sung, Dong-Wook;Park, Yong-Koo
고경란;류경남;박지선;진욱;성동욱;박용구

  • Published : 20080000
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Abstract

Purpose: to evaluate the serial ultrasonographic findings of experimental intramuscular hemorrhaging to determine if there is a correlation with the pathologic findings. Materials and Methods: An uiltrasonography (US) was performed before and immediately after an intramuscular blood injection in nine rabbits. In addition, follow-up US images were obtained at 1, 4, 7, 10, 14, 21, and 28 days after the intramuscular blood injections in seven of the rabbits. The pathologic specimens, compared to the US findings on each date, and consisted of samples of left thigh muscle. Results: A US, performed immediately after a blood injection, showed two patterns; 6 cases of hyperechoic muscle thickening and 3 cases of hyperechoic muscle thickening with extravasation between the epimysium and muscle bundle or within muscle bundle. A follow-up US showed a marked decrease in intramuscular hemorrhaging and microcalcifications, which appeared on the 4th, 7th and 10th day after the blood injection. The pathologic findings revealed several short echogenic lines in the muscular bundles which were hemosiderin. Moreover, a 28 day follow-up US revealed that the normal findings are correlated with the normal gross pathologic findings. Conclusion: The US findings of the intramuscular hemorrhaging, for each of the follow-up dates, in comparison to the pathologic findings, revealed a high correlation with the pathologic specimens. Consequently, a US transducer with high resolution can be considered as a helpful technique in the diagnosing and evaluating the follow-up treatment of intramuscular hemorrhaging.

목적: 실험토끼에서 근육내출혈의 시간경과에 따른 초음파소견의 변화를 알아보고 병리소견과 비교, 분석하여 그 연관성을 알아보고자 한다. 대상과 방법: 아홉 마리의 토끼에서 자가 혈액을 왼쪽 대퇴부후방에 주입하였다. 아홉 마리에서 실험 직전 직후에 모두 초음파검사를 실시하였고, 일곱 마리에서는 1일, 4일, 7일, 10일, 2주, 3주 4주 후에 각각 추적초음파검사를 시행하였다. 두 마리는 실험 직후, 일곱 마리에서는 각각의 추적초음파가 끝난 후 대퇴부 근육검체를 얻었다. 검체의 병리소견을 살펴보고 초음파영상소견과 비교, 분석하였다. 결과: 대퇴부 혈액주입 직후 시행한 초음파는 두 가지 패턴을 보였다; 고에코성 근육비후로만 보이거나(6예) 근육비후와 함께 근육바깥막과 근육다발사이 혹은 근육다발 내 혈종이 동반되었다(3예). 4일 추적초음파에서는 근육내출혈의 양이 현저히 감소하였고 몇 개의 작은 무에코 부위주변으로 강한 고에코테두리가 보였는데, 이는 병리소견에서 비감염성 미세농양 주위의 미세석회와 일치하였다. 2주 추적초음파에서는 근육다발막과 구별되는 여러 개의 짧은 고에코선들이 근육다발 내에서 보였는데 이는 혈철소침착과 동반된 섬유조직에 의한 것이었다. 4주에 거의 모든 초음파소견과 병리소견은 정상화 되었다. 결론: 고에코성 근육비후로 보인 근육내출혈의 시간경과에 따른 초음파소견은 병리조직학소견과 높은 상관성을 보여주었다. 따라서 고해상도탐촉자를 이용한 근육내출혈의 초음파소견을 이해하는 것이 추적검사 시 매우 유용할 것으로 생각된다.

Keywords

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