Journal of Acupuncture Research

Korean Acupuncture & Moxibustion Medicine Society (대한침구의학회)
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Effects of Imeup($GB_{41}$) Supplementation and Tonggok($BL_{66}$) Draining on Changes in Cerebral Hemodynamics in Normal Rats

수소양삼초정격(手少陽三焦正格) 타경보사(他經補瀉)(임읍 보(臨泣 補), 통곡 사(通谷 瀉)) 자침(刺鍼)이 정상 흰쥐의 뇌혈류역학(腦血流力學) 변화(變化)에 미치는 영향(影響)

  • Lim, Myung-Jang (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Dongshin University) ;
  • Ryu, Chung-Ryeol (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Dongshin University) ;
  • Cho, Myung-Rae (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Dongshin University)
  • 임명장 (동신대학교 한의과대학 침구학교실) ;
  • 류충열 (동신대학교 한의과대학 침구학교실) ;
  • 조명래 (동신대학교 한의과대학 침구학교실)
  • Published : 2008.10.20
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Abstract

Objectives : The purpose of this study is to investigate the effects of $GB_{41}$ supplementation and $BL_{66}$ draining on changes in cerebral blood flow in normal rats. Methods : Regional cerebral blood flow(rCBF) and mean arterial blood pressure(MABP) in normal rats are observed, and those mechanisms were also investigated with pre-treatment of indomethacin(IDM) and methylene blue(MTB) each. Results : In this study, $GB_{41}$ supplementation and $BL_{66}$ draining elevated rCBF in time-dependent manner. Pre-treatment with indomethacin(IDM), an inhibitor of cyclooxygenase, inhibited increase of rCBF effectively. But pre-treatment with methylene blue(MTB), an inhibitor of guanylate cyclase, didn't affect rCBF levels. In addition, pre-treatment with IDM also decreased MABP levels. Conclusions : In conclusion, these results suggest that $GB_{41}$ supplementation and $BL_{66}$ draining is effective to increase rCBF, and the mechanisms are thought to be related to cyclooxygenase pathways.

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