Journal of Preventive Medicine and Public Health

The Korean Society for Preventive Medicine (대한예방의학회)
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Serum Ferritin and Risk of the Metabolic Syndrome in Some Korean Rural Residents

농촌 지역 주민의 혈청 Ferritin 수준과 대사증후군과의 관련성

  • Ryu, So-Yeon (Department of Preventive Medicine, Chosun University College of Medicine) ;
  • Kim, Ki-Soon (Department of Preventive Medicine, Chosun University College of Medicine) ;
  • Park, Jong (Department of Preventive Medicine, Chosun University College of Medicine) ;
  • Kang, Myeng-Guen (Department of Preventive Medicine, Chosun University College of Medicine) ;
  • Han, Mi-Ah (Department of Preventive Medicine, Chosun University College of Medicine)
  • 류소연 (조선대학교 의과대학 예방의학교실) ;
  • 김기순 (조선대학교 의과대학 예방의학교실) ;
  • 박종 (조선대학교 의과대학 예방의학교실) ;
  • 강명근 (조선대학교 의과대학 예방의학교실) ;
  • 한미아 (조선대학교 의과대학 예방의학교실)
  • Published : 2008.03.31
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Abstract

Objectives : The purpose of this study was to examine the relationship between serum ferritin and the metabolic syndrome (MS). Methods : We conducted a cross-sectional study of 1,444 adults over age 40 and under age 70 that lived in a rural area and participated in a survey conducted as part of the Korean Rural Genomic Cohort Study (KRGCS). The MS was defined as the presence of at least three of the followings : elevated blood pressure, low high density lipoprotein cholesterol, elevated serum triglycerides, elevated plasma glucose, or abdominal obesity. After adjustment for age, alcohol intake, menopausal status, body mass index (BMI), high sensitivity C-reactive protein (hs-CRP), and alanine aminotransferase (ALT), odds ratios (ORs) for the prevalence of the MS by sex were calculated for quartiles of serum ferritin using logistic regression analysis. Results : The MS was more common in those persons , with the highest levels of serum ferritin, compared to persons with the lowest levels, in men (37.1% vs. 22.4%, p=0.006) and women (58.8% vs. 34.8, p<0.001). In both sexes, the greater the number of MS components presents, the greater the serum ferritin levels. After adjustment for age, alcohol intake, and menopausal status, the OR for metabolic syndrome, comparing the fourth quartile of ferritin with the first quartile, was 2.21 (95% confidence interval; CI=1.26-3.87; p-trend=0.024) in men and 2.10 (95% CI=1.40-3.17; p-trend=0.001) in women. However, after further adjustment for BMI, hs-CRP, and ALT, the ORs were statistically attenuated in both sexes. Conclusions : Moderately elevated serum ferritin levels were not independently associated with the prevalence of the MS after adjusting for other risk factors. Further studies are needed to obtain evidence concerning the association between serum ferritin levels and the MS.

Keywords

References

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