International Journal of Precision Engineering and Manufacturing

Korean Society for Precision Engineering (한국정밀공학회)
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Fabrication of Composite Drug Delivery System Using Nano Composite Deposition System and in vivo Characterization

  • Chu, Won-Shik (School of Mechanical and Aerospace Engineering, Seoul University) ;
  • Jeong, Suk-Yong (School of Mechanical and Aerospace Engineering, Seoul University) ;
  • Pandey, Jitendra Kumar (School of Mechanical and Aerospace Engineering, Seoul University) ;
  • Ahn, Sung-Hoon (School of Mechanical and Aerospace Engineering & Institute of Advanced and Design, Seoul University) ;
  • Lee, Jae-Hoon (College of Pharmacy, Sungkyunkwan University) ;
  • Chi, Sang-Cheol (College of Pharmacy, Sungkyunkwan University)
  • Published : 2008.04.01
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Abstract

The Rapid Prototyping (RP) technology has advanced in many application areas. In this research, two different types, cylinder and scaffold, of implantable Drug Delivery System (DDS) were fabricated using Nano Composite Deposition System (NCDS), one of the RP systems. The anti-cancer drug (5-fluorouracil, 5-FU), biodegradable polymer (PLGA(85: 15)), and bio ceramic (Hydroxyapatite, HA) were used to form drug-polymer composite material. Both types of DDS were evaluated in vivo environment for two weeks. For evaluation, the cumulative drug release and shape stability were measured. Test results showed that the scaffold DDS provide higher cumulative drug release and has better stability than cylinder DDS.

Keywords

References

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