Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Carcinostatic effect of allergen removed Rhus Verniciflua stokes based Traditional Korean Medicine on a patient with lung adenocarcinoma; single case report

  • Jeong, Jong-Soo (M.U Integrative Cancer Center, East-West Neo Medical Center, Kyung-Hee University) ;
  • Park, Jae-Woo (Department of Internal Medicine, College of Oriental Medicine, Kyung-Hee University) ;
  • Yoon, Seong-Woo (M.U Integrative Cancer Center, East-West Neo Medical Center, Kyung-Hee University) ;
  • Choi, Won-Cheol (M.U Integrative Cancer Center, East-West Neo Medical Center, Kyung-Hee University)
  • Published : 2008.02.29
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Abstract

Lung cancer is one of the leading causes of cancer mortality and overall treatment outcomes for lung cancer are still to be considered disappointing despite of development of new medical therapeutics on cancer. Cytostatic agents are considered as novel medication in the treatment of cancer though its benefit is most appropriately assessed through survival end points rather than the objective-response end points. We present a case of a lung adenocarcinoma patient who showed tumor lesion in patient's two different lung sites. From the day of diagnosis, the tumor lesion stayed with the almost same size with more than 1 year of Allergen-Removed Rhus Verniciflua Stokes (A-RVS) based Traditional Korean Medicine treatment without any western conventional treatment. No significant side effect was noted and the patient maintained good performance status throughout the treatment period. We assume A-RVS may have cytostatic effect on NSCLC patient and our observation justifies further investigation.

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References

  1. Dan Bensky. (1993) Chinese Herbal Medicine: Materia Medica. Eastland Press. p.293
  2. Dennis L Kasper et al. (2005) Harrison's Principles of Internal Medicine. 16th edition. McGraw-Hill p. 506-507
  3. Ellis LM. (2006) Mechanisms of action of bevacizumab as a component of therapy for metastatic colorectal cancer. Semin. Oncol. 33, S1-7 https://doi.org/10.1053/j.seminoncol.2006.08.002
  4. Giovanni Maciocia. (1980) The foundation of Chinese Medicine. Churchill Livingstone. pp.193-194
  5. Gridelli C, Maione P, Rossi A, De Marinis F. (2007) The role of bevacizumab in the treatment of nonsmall cell lung cancer: current indications and future developments. Oncologist 12, 1183-1193 https://doi.org/10.1634/theoncologist.12-10-1183
  6. Jang HS, Kook SH, Son YO, Kim JG, Jeon YM, Jang YS, Choi KC, Kim J, Han SK, Lee KY, Park BK, Cho NP, Lee JC. (2005) Flavonoids purified from Rhus verniciflua Stokes actively inhibit cell growth and induce apoptosis in human osteosarcoma cells. Biochim. Biophys. Acta. 1726, 309-316
  7. Jong-soo Jeong, Kyung-suk Kim, Jae-woo Park, Hyunsik Jung, Seong-woo Yoon. (2007) A Case of Malignant Melanoma Patient Treated with Allergen-removed Rhus Verniciflua Stokes. Korean J. Orient. Int. Med. 28, 655-661
  8. Kim JH, Kim HP, Jung CH, Hong MH, Hong MC, Bae HS, Lee SD, Park SY, Park JH, Ko SG. (2006) Inhibition of cell cycle progression via p27Kip1 upregulation and apoptosis induction by an ethanol extract of Rhus verniciflua Stokes in AGS gastric cancer cells. Int. J. Mol. Med. 18, 201-208
  9. Kitts DD, Lim KT. (2001) Antitumorigenic and cytotoxic properties of an ethanol extract derived from Rhus verniciflua Stokes (RVS). J. Toxicol. Environ. Health A 64, 357-371 https://doi.org/10.1080/152873901316981330
  10. Lee SJ, Oh PS, Lim K, Lim KT. (2005) 6 kDa glycoprotein isolated from Rhus verniciflua stokes inhibits G/GO-induced mitochondrial apoptotic signal pathways in BNL CL.2 cells. Basic Clin. Pharmacol. Toxicol. 97, 399-405 https://doi.org/10.1111/j.1742-7843.2005.pto_184.x
  11. Lin J, Dong HF, Oppenheim JJ, Howard OM. (2003) Effects of astragali radix on the growth of different cancer cell lines. World J. Gastroenterol. 9, 670-673
  12. Ratain MJ, Stadler WM. (2001) Clinical trial designs for cytostatic agents. J. Clin. Oncol. 19, 3154-3155
  13. Seong-woo Yoon, Kyung-suk Kim, Jae-woo Park, Hyun-sik Jung, Won-Cheol Choi. (2006) The Study on the Safety and Case Series of the Acute Lymphocytic Leukemia using Rhus Verniciflua Strokes Extract. J. Kor. Orient. Oncol. 11, 1-21
  14. Seong-Woo Yoon. Sang-Jae Park, Kyung-Suk Kim, Hyun-Sik Jung, Won-Cheol Choi. (2006) The Study on the Progress and Quality Control of Rhus Verniciflua Strokes Extract (Nexia). J. Kor. Orient. Oncol. 11, 31-39
  15. Won-Cheol Choi, Jae-Ho Lee, Eun-Ok Lee, Hyo-Jung Lee, Sung-Woo Yoon, Kyoo-Seok Ahn, Sung-Hoon Kim. (2006) Study on Antiangiogenic and Antitumor Activities of Processed Rhus Verniciclua Strokes Extract. Korean J. Orient. Physil. Pathol. 20, 825-829
  16. Woodward RM, Brown ML, Stewart ST, Cronin KA, Cutler DM. (2007) The value of medical interventions for lung cancer in the elderly: results from SEERCMHSF. Cancer 110, 2511-2518 https://doi.org/10.1002/cncr.23058

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