The Korean Journal of Pesticide Science (농약과학회지)

The Korean Society of Pesticide Science (한국농약과학회)
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A Synthesis of New Fluorine-containing Phenylformamidines and Their Insecticidal Activities

새로운 불소함유 Phenylformamidine 유도체의 합성과 살충활성

  • Lee, Dong-Guk (Drug Discovery Division, Korea Research Institute of Chemical Technology) ;
  • Chung, Kun-Hoe (Drug Discovery Division, Korea Research Institute of Chemical Technology) ;
  • Ko, Young-Kwan (Drug Discovery Division, Korea Research Institute of Chemical Technology) ;
  • Ryu, Jae-Wook (Drug Discovery Division, Korea Research Institute of Chemical Technology) ;
  • Woo, Jae-Chun (Drug Discovery Division, Korea Research Institute of Chemical Technology) ;
  • Koo, Dong-Wan (Drug Discovery Division, Korea Research Institute of Chemical Technology) ;
  • Choi, Yong-Ho (Drug Discovery Division, Korea Research Institute of Chemical Technology) ;
  • Park, No-Joong (Drug Discovery Division, Korea Research Institute of Chemical Technology) ;
  • Hong, Mi-Sook (Dongbu Hitec Agrolife Research Institute) ;
  • Kim, Tae-Joon (Dongbu Hitec Agrolife Research Institute)
  • 이동국 (한국화학연구원 신약연구단) ;
  • 정근회 (한국화학연구원 신약연구단) ;
  • 고영관 (한국화학연구원 신약연구단) ;
  • 류재욱 (한국화학연구원 신약연구단) ;
  • 우재춘 (한국화학연구원 신약연구단) ;
  • 구동완 (한국화학연구원 신약연구단) ;
  • 최용호 (한국화학연구원 신약연구단) ;
  • 박노중 (한국화학연구원 신약연구단) ;
  • 홍미숙 ((주)동부하이텍 농생명 연구소) ;
  • 김태준 ((주)동부하이텍 농생명 연구소)
  • Published : 2008.09.30
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Abstract

Phenylformamidines are well known as insecticides for their specific activity against the insects. It has now been established that they show insecticidal activity as agonists on the octopamine receptor which is located in the synapse membrane. In this study we tried to test the effect of fluorine substituted aromatic formamidines and 1,3,5-triazapenta-1,4-dienes. Among the compounds, 2h, 2k, 21, 3g, 3h, 3k showed good activity against mite and aphid and 4f and 4g showed high activity against mite.

Phenylformamidine계 유도체들은 곤충의 신경전달 물질인 octopamine과 경쟁적으로 octopamine receptor에 작용하여 살충 활성을 나타내는 것으로 알려져 있다. 본 연구에서는 불소를 함유하는 다양한 aniline으로부터 amitraz와 유사한 구조의 새로운 화합물을 합성하여 이들의 살충활성을 시험하였다. N'-monomethyl-N-phenylformamidine 유도체들 중에서 2h, 2k, 21, N',N'-dimethyl-N-phenylformamidine 유도체들 중에서 3g, 3h, 3k 화합물이 응애류와 진딧물류에 대해서 높은 살충 활성을 보였으며, 1,3,5-triaza-penta-1,4-diene 유도체들 중에서 4f, 4g 화합물들이 응애류에 대해서 높은 살충 활성을 보였다.

Keywords

References

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