Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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A Study on the Cosmeceutical activities of Prunus Sargentii R.

산벚나무(Prunus sargentii R.) 수피의 화장품활성에 관한 연구

  • Park, Jung-Mi (Department of Cosmeceutical Science, Daegu Haany University) ;
  • Lee, Jin-Young (Department of Cosmeceutical Science, Daegu Haany University) ;
  • Park, Tae-Soon (Department of Cosmeceutical Science, Daegu Haany University) ;
  • Hyun, Sok-Jun (Department of Cosmeceutical Science, Daegu Haany University) ;
  • Kim, Han-Hyuk (Department of Cosmeceutical Science, Daegu Haany University) ;
  • Cho, Young-Je (Department of Food Engineering, Sangju National University) ;
  • Kwon, O-Jun (Gyeongbuk Regional Innovation Agency) ;
  • Son, Ae-Ryang (Department of Beauty Design, Gyeongnam Provincial Collage in Geochang) ;
  • Kim, Dong-Seok (Gounmi skin laser/aesthetic clinic) ;
  • An, Bong-Jeun (Department of Cosmeceutical Science, Daegu Haany University)
  • 박정미 (대구한의대학교 화장품약리학과) ;
  • 이진영 (대구한의대학교 화장품약리학과) ;
  • 박태순 (대구한의대학교 화장품약리학과) ;
  • 현석준 (대구한의대학교 화장품약리학과) ;
  • 김한혁 (대구한의대학교 화장품약리학과) ;
  • 조영제 (상주대학교 식품공학과) ;
  • 권오준 (경북전략산업기획단) ;
  • 손애량 (경남도립거창대학 뷰티디자인과) ;
  • 김동석 (고은미피부과) ;
  • 안봉전 (대구한의대학교 화장품약리학과)
  • Published : 2008.03.31
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Abstract

Prunus sargentii R. of Rosaceae familiy, has been reported to have radical scavenging activity and anti-inflammatory effect. On these facts, biological activity and safety test were conducted to evaluate biological activities of the extracts of P. sargentii R. as a potential pharmaceutical ingredient. The electron donating ability of its ethanol extracts at a 500 ppm level showed 92%, which was higher than that of hot water extract (59%), the superoxide dismutase (SOD)-like activity of the water extract of P. sargentii R. was about 50%, the ethanol extract of P. sargentii R. was about 40% at 1,000 ppm concentration. Xanthine oxidase inhibition by the water extract of P. sargentii R. was about 40% and that by the ethanol extract was 60% respectively at 500 ppm concentration. From the measurement on lipid oxidation, the $Cu^{2+}$ chelating effect of the ethanol extract was higher than that of hot water extract. The $Fe^{2+}$ chelating effect was also shown to be about 80% at a 500 ppm concentration in both hot water extract and ethanol extract. The tyrosinase inhibition effect related to skin-whitening was 26% by hot water extract and 20% by ethanol extract respectively at a 1,000 ppm. Hyaluronidase inhibition activity related to the anti-inflammation effect was 96% in ethanolic extract at a 500 ppm. Clear zones formed by P. sargentii R. against the human skin-resident micro-flora such as Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli and Propionibacterium acnes indicated that antimicrobial activity of the ethanol extract was higher than that of the hot water extract.

산벚나무는 장미과에 속하는 것으로, 수피인 화피의 radical 소거능과 항염증 효과가 보고되고 있어, 이를 이용하여 화장품 원료로 이용하고자 생리활성을 검증하였다. 전자공여능은 에탄올추출물 500 ppm에서 92%의 효능을 보여 열수추출물 59% 보다 우수하였고, SOD 유사활성의 경우 열수추출물 1,000 ppm에서 에탄올추출물의 경우는 50%의 활성능을 나타내었다. xanthine oxidase 저해능은 500 ppm의 농도에서 열수추출물의 경우 40%, 에탄올추출물의 경우 60%의 저해능을 나타내었다. 지방산패 억제능 측정의 경우 $Cu^{2+}$에 의한 저해 효과는 열수추출물보다 에탄올추출물의 효과가 높았으며, $Fe^{2+}$에 의한 저해 효과는 열수와 에탄올추출물 모두 500 ppm에서 80% 이상의 저해능을 보였다. 피부미백과 관련된 tyrosinase 저해능의 경우 1,000 ppm에서 열수추출물의 경우는 26%, 에탄올추출물의 경우 20%의 저해능을 보였다. 항염증과 관련된 hyaluronidase 저해능의 경우 500ppm에서 에탄올추출물의 경우 96%의 효능을 보였다. 산벚나무 수피추출물의 피부상재균인 Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli 및 Propionibacterium acne에 대한 저해환형성을 관찰한 결과 열수추출물보다 에탄올추출물의 효능이 더 우수하였다.

Keywords

References

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