Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Anti-hypercholesterolemic Effects of Wasabia japonica in High Cholesterol-Fed SD Strain Rats

고추냉이가 고콜레스테롤 식이 흰쥐의 콜레스테롤 농도에 미치는 영향

  • Lee, Young-Sun (Department of Traditional Health Resource Development, College of Sung Duk)
  • 이영선 (성덕대학, 전통건강자원개발학과)
  • Published : 2008.05.30
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Abstract

This study was carried out to investigate the anti-hypercholesterolemic effects of Wasabia japonica (WJ) in hypercholesterolemic rats. Sprague-Dawley male rats were randomly assigned to one normal diet and three high cholesterol diet groups which contained 1% (w/w) cholesterol. After 4 weeks cholesterol diet, the groups of high cholesterol diet were classified to control (normal diet only), WJR5 (normal diet plus 5% WJ root) and WJL5 (normal diet plus 5% WJ leaf). There were no difference in the body weight gain, food intake and Food efficacy ratio (FER). The liver and kidney weights change of high cholesterol diet groups were higher than the normal diet group (p<0.05), but there was no significant difference of change between control and WJ diet groups. Concentration of serum HDL-cholesterol were significantly increased in WJ diet groups compared with control group (p<0.05). Concentration of serum LDL-cholesterol were significantly decreased in the groups of WJR5 diet compared with control group (p<0.05). The results of the study indicate that the diet of WJ can ameliorate the status of HDL-cholesterol and LDL-cholesterol in high cholesterol diet rats. In view of these results, WJ is expected to be an effective material for the anti-hypercholesterolemic in high cholesterol diet rats.

고추냉이의 항고콜레스테롤 효과를 실험적으로 평가하고자 콜레스테롤 식이로 고콜레스테롤혈증을 유발시킨 흰쥐에 정상 식이와 고추냉이 잎과 뿌리 첨가 식이를 급여 하여 흰쥐의 식이 효율, 총콜레스테롤, HDL-콜레스테롤 및 LDL-콜레스테롤 농도의 변화를 측정하였다. 식이 효율은 정상 식이군, 대조군,WJL5 및 WJR5 식이군 간의 차이는 관찰되지 않았다. 간, 신장 및 비장의 무게의 변화는 간과 신장의 경우 고콜레스테롤 식이를 급여한 모든 실험군에서 정상군에 비해 5% 수준에서 유의적인 차이가 인정되었다, 총콜레스테롤 농도의 경우 WJL5와 WJR5 식이 첨가군은 대조군에 비해 유의적인 차이는 인정되지 않았으나 총콜레스테롤 농도가 감소하는 경향이 관찰되었다. HDL-콜레스테롤 농도의 경우 대조군에 비해 고추냉이 첨가 식이(WJL5, WJR5)군에서 5% 수준에서 유의적으로 증가되었으며, LDL-콜레스테롤 농도의 경우 대조군에 비해 WJR5 군에서 5% 수준에서 유의 적으로 감소하는 경향이 관찰되었다.

Keywords

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