The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Effects of Rhodiola rosea (KH101) on Anti-fatigue in Forced Swimming Rats

홍경천(紅景天)추출물(KH101)이 강제유영 흰쥐의 피로회복에 미치는 영향

  • Jung, Hyuk-Sang (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Kim, Eun-Young (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Shim, Eun-Sheb (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Lee, Hyun-Sam (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Moon, Eun-Jung (Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Jin, Zhen-Hua (Kyung Hee Management Compeny) ;
  • Kim, Sun-Yeou (Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Sohn, Young-Joo (College of Oriental Medicine, Sangji University) ;
  • Sohn, Nak-Won (Graduate School of East-West Medical Science, Kyung Hee University)
  • 정혁상 (경희대학교 한의과대학, 한의학연구소) ;
  • 김은영 (경희대학교 한의과대학, 한의학연구소) ;
  • 심은섭 (경희대학교 한의과대학, 한의학연구소) ;
  • 이현삼 (경희대학교 한의과대학, 한의학연구소) ;
  • 문은정 (경희대학교 동서의학대학원) ;
  • 김진화 ((주)경희매니지먼트컴퍼니) ;
  • 김선여 (경희대학교 동서의학대학원) ;
  • 손영주 (상지대학교 한의과대학) ;
  • 손낙원 (경희대학교 동서의학대학원)
  • Published : 2008.12.31
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Abstract

Objectives : Rhodiola rosea has been used in herbal medicine to treat various conditions, such as antimelancholia, antifatigue, improvement of work competence and prevention of altitude sickness. In this study, we investigated effects of Rhodiola rosea extract (KH101) on fatigue in forced swimming rats. Methods : Sprague-Dawley rats were induced with fatigue by forced swimming, then rats in each group were treated with KH101. We observed changes of glucose, LDH and cortisol in serum and LDH, glycogen, hexokinase, citrate synthase MDH, SDH and CK in muscle. Results : Obtained results were as follows: 1. Continuance times of exercise significantly increased in all groups at day 1, in the 50 mg/kg concentration group at day 2, in all groups at day 3 and in the 50 mg/kg conc. group at day 4. 2. In serum, glucose significantly decreased in all concentration groups. 3. In the soleus muscle, LDH significantly decreased in the 50 mg/kg concentration group. HK significantly decreased in the 100 mg/kg conc. group. SDH significantly increased in the 100 mg/kg conc. MDH were significantly decreased in all conc. groups. 4. In the gastrocnemius muscle, HK significantly decreased in all concentration groups, while MDH significantly increased all conc. groups. Conclusions : It is concluded that the KH101 has and anti-fatigue effect in rats. Additional studies are needed to find the mechanism of the association between each single herb.

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