Journal of the Korean Society for Precision Engineering (한국정밀공학회지)

Korean Society for Precision Engineering (한국정밀공학회)
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Effect of Whole Body Vibration on Osteoporotic Trabecular Bone of Rats - Compared with the Effect of Actonel

전신진동이 골다공증이 유발된 쥐 해면골에 미치는 영향 - 골다공증 치료제 효과와 비교

  • 고창용 (연세대학교 보건과학대학 의공학부) ;
  • 이태우 (연세대학교 보건과학대학 의공학부) ;
  • 우대곤 (연세대학교 보건과학대학 의공학부) ;
  • 김효선 (연세대학교 보건과학대학 의공학부) ;
  • 김한성 (연세대학교 보건과학대학 의공학부) ;
  • 이법이 (건국대학교 의과대학) ;
  • 임도형 (연세대학교 보건과학대학 의공학부)
  • Published : 2008.05.01
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Abstract

Pharmacotherapy was mainly used to treat osteoporosis. However, some researches showed that pharmacotherapy could induce unexpected adverse effects. Some studies showed that whole body vibration affected beneficially osteoporosis. This paper studied the effect of whole body vibration fur osteoporosis compared with the effect of pharmacotherapy. 10 female rats were used and allocated into 4 group, CON, SHAM, DRUG, and WBV. Rats except SHAM group were ovariectomised to induce osteoporosis. Rats in WBV group were stimulated in whole body vibration at magnitude of $1mm_{peak-peak}$ and frequency 45Hz, for 8 weeks (30 min/day, 5 days/week). Rat in DRGU group was orally administered the Actonel (0.58mg/Kg), for 8 weeks (5days/week). The $4^{th}$ lumbar in rats were scanned at a resolution of $35{\mu}m$ at baseline, before stimulation, and 8 weeks after stimulation by In-vivo micro computed tomography. For detecting and tracking changes of biomechanical characteristics (morphological and mechanical characteristics) in lumbar trabecuar bone of rats, structural parameters were measured and calculated from acquiring images and finite element analysis was performed. In the results, loss of quantity and change of structure of trabecular bone in WBV group were smaller than those in both CON and SHAM groups. In addition, mechanical strength in WBV group was stronger than that in both CON and SHAM groups. In contrast, biomechanical characteristics in WBV group were similar with those in DRUG group. These results showed that reasonable whole body vibration was likely to treat osteoporosis and be substituted partly for drug treatment.

Keywords

References

  1. Wasnich, R. and Miller, P., "Antifracture efficacy of antiresorptive agents are related to changes in bone density," J. Clin. Endocrinol. Metab., Vol. 85, No. 1, pp. 231-236, 2000 https://doi.org/10.1210/jc.85.1.231
  2. Reginster, J., Minne, H., Sorensen, O., Hooper, M., Roux, C., Brandi, M., Lund, B., Ethgen, D., Pack, S., Roumagnac, I. and Eastell, R., "Randomized trial of the effects of risedronate on vertebral fractures in women with established postmenopausal osteoporosis. Vertebral Efficacy with Risedronate Therapy (VERT) Study Group," Osteoporos Int., Vol. 11, No. 1, pp. 83-91, 2000 https://doi.org/10.1007/s001980050010
  3. Ito, M., Nishida, A., Aoyagi, K., Uetani, M., Hayashi, K. and Kawase, M., "Effects of risedronate on trabecular microstructure and biomechanical properties in ovariectomized rat tibia," Osteoporos Int., Vol. 16, No. 9, pp. 1042-1048, 2005 https://doi.org/10.1007/s00198-004-1802-3
  4. Grady, D., Ettinger, B., Moscarelli, E., Plouffe, L. J., Sarkar, S., Ciaccia, A. and Cummings, S., "Multiple Outcomes of Raloxifene Evaluation Investigators: Safety and Adverse Effects Associated with Raloxifene: Multiple Outcomes of Raloxifene Evaluation," Obstet. Gynecol., Vol. 104, No. 4, pp. 837-844, 2004 https://doi.org/10.1097/01.AOG.0000137349.79204.b8
  5. Schairer, C., Lubin, J., Troisi, R., Sturgeon, S., Brinton, L. and Hoover, R., "Menopausal Estrogen and Estrogen-Progestin Replacement Therapy and Breast Cancer Risk," JAMA, Vol. 283, No. 4, pp. 485-491, 2000 https://doi.org/10.1001/jama.283.4.485
  6. Lacey, J. J., Mink, P., Lubin, J., Sherman, M., Troisi, R., Hartge, P., Schatzkin, A. and Schairer, C., "Menopausal hormone replacement therapy and risk of ovarian cancer," JAMA, Vol. 288, No. 3, pp. 334-341, 2002 https://doi.org/10.1001/jama.288.3.334
  7. Porthouse, J., Cockayne, S., King, C., Saxon, L., Steele, E., Aspray, T., Baverstock, M., Birks, Y., Dumville, J., Francis, R., Iglesias, C., Puffer, S., Sutcliffe, A., Watt, I. and Torgerson, D., "Randomised controlled trial of calcium and supplementation with cholecalciferol (vitamin D3) for prevention of fractures in primary care," BMJ., Vol. 330, No. 7498, p. 1003, 2005 https://doi.org/10.1136/bmj.330.7498.1003
  8. Oxlund, B., Ortoft, G., Andreassen, T. and Oxlund, H., "Low-intensity, high-frequency vibration appears to prevent the decrease in strength of the femur and tibia associated with ovariectomy of adult rats," Bone, Vol. 32, No. 1, pp. 69-77, 2003 https://doi.org/10.1016/S8756-3282(02)00916-X
  9. Rubin, C., Sommerfeldt, D., Judex, S. and Qin, Y., "Inhibition of osteopenia by low magnitude, high-frequency mechanical stimuli," Drug Discov. Today, Vol. 6, No. 16, pp. 848-858, 2001 https://doi.org/10.1016/S1359-6446(01)01872-4
  10. Rubin, C., Turner, A., Bain, S., Mallinckrodt, C. and McLeod, K., "Low mechanical signals strengthen long bone," Nature, Vol. 412, No. 6847, pp. 603-604, 2001
  11. Rubin, C., Turner, A., Müller, R., Mittra, E., McLeod, K., Lin, W. and Qin, Y., "Quantity and quality of trabecular bone in the femur are enhanced by a strongly anabolic, noninvasive mechanical intervention," J. Bone Miner. Res., Vol. 17, No. 2, pp. 349-357, 2002 https://doi.org/10.1359/jbmr.2002.17.2.349
  12. Flieger, J., Karachalios, T., Khaldi, L., Raptou, P. and Lyritis, G., "Mechanical Stimulation in the Form of Vibration Prevents Postmenopausal Bone Loss in Ovariectomized Rats," Calcif. Tissue Int., Vol. 63, No. 6, pp. 510-514, 1998 https://doi.org/10.1007/s002239900566
  13. Verschueren, S., Roelants, M., Delecluse, C., Swinnen, S., Vanderschueren, D. and Boonen, S., "Effect of 6-Month Whole Body Vibration Trainingon Hip Densisy, Muscle Strength, and Postural Control in Postmenopausal Women : A Randomized Constrolled Pilot Study," J. Bone Miner. Res., Vol. 19, No. 3, pp. 352-359, 2004 https://doi.org/10.1359/JBMR.0301245
  14. Ko, C., Lee, T., Woo, D., Kim, H., Kim, C. and Lee, B., "Effect of vibration on trabecular bone of OVX rats," Proceeding of the Korean Society for Precision Engineering Spring Conference, pp. 183-184, 2006
  15. Cowin, S., "Bone mechanics handbook," 2nd, CRC press, pp. 1-32, 2000
  16. Kinney, J., Haupt, D., Balooch, M., Ladd, A., Ryaby, J. and Lane, N., "Three-dimensional morphometry of the L6 vertebra in the ovariectomized rat model of osteoporosis: biomechanical implications," J. Bone Miner. Res., Vol. 15, No. 10, pp. 1981-1991, 2000 https://doi.org/10.1359/jbmr.2000.15.10.1981
  17. Ko, C., Woo, D., Lee, T., Kim, H., Lee, B. and Tack, G., "Detecting and Tracking Changes of Mechanical Characteristics of the Trabecular and Cortical Bone in the Lumbar Vertebrae of an OVX Rat - Use of In-Vivo Micro-CT and Micro-FE Analysis-," Journal of KSPE, Vol. 24, No. 1, pp. 110-117, 2007
  18. Waarsing, J., Day, J., van der Linden, J., Ederveen, A., Spanjers, C., De Clerck, N., Sasov, A., Verhaar, J. and Weinans, H., "Detecting and tracking local changes in the tibiae of individual rats: a novel method to analyse longitudinal in vivo micro-CT data," BONE, Vol. 34, Issue 1, pp. 163-169, 2004 https://doi.org/10.1016/j.bone.2003.08.012
  19. Ke, H., Chen, H., Qi, H., Pirie, C., Simmons, H., Ma, Y., Jee, W. and Thompson, D., "Effects of droloxifene on prevention of cancellous bone loss and bone turnover in the axial skeleton of aged, ovariectomized rats," Bone, Vol. 17, No. 5, pp. 491-496, 1995 https://doi.org/10.1016/8756-3282(95)00346-2
  20. Rubin, C., Pope, M., Fritton, J., Magnusson, M., Hansson, T. and McLeod, K., "Transmissibility of 15-hertz to 35-hertz vibrations to the human hip and lumbar spine: determining the physiologic feasibility of delivering low-level anabolic mechanical stimuli to skeletal regions at greatest risk of fracture because of osteoporosis," Spine, Vol. 28, No. 23, pp. 2621-2627, 2003 https://doi.org/10.1097/01.BRS.0000102682.61791.C9