Journal of Korean Medicine for Obesity Research (한방비만학회지)

The Society of Korean Medicine for obesity Research (한방비만학회)
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The Inhibitory Effects of Sansayukbokhap-bang(SSYBHB) on the Obese-Mouse Induced High Fat Diet

산사육복합방(山査肉複合方)이 생쥐의 비만억제에 미치는 영향

  • Kim, Hyong-Jun (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Daejeon University) ;
  • Hong, Seo-Young (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Daejeon University) ;
  • Heo, Dong-Seok (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Daejeon University) ;
  • Yoon, Il-Ji (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Daejeon University) ;
  • Oh, Min-Seok (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Daejeon University)
  • 김형준 (대전대학교 한의과대학 한방재활의학과 교실) ;
  • 홍서영 (대전대학교 한의과대학 한방재활의학과 교실) ;
  • 허동석 (대전대학교 한의과대학 한방재활의학과 교실) ;
  • 윤일지 (대전대학교 한의과대학 한방재활의학과 교실) ;
  • 오민석 (대전대학교 한의과대학 한방재활의학과 교실)
  • Published : 2008.06.30
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Abstract

Objectives In order to investigate the effects of Sansayukbokhap-bang (SSYBHB) on the hematological and histological changes. Methods C57BL/6 mice were fed with high fat diet. C57BL/6 mice were divided into four groups and fed for 15weeks. Results 1. The body weight of SSYBHB intake mice was significantly lower than high fat diet group. 2. The final increase of body weight was decreased significantly. 3. The levels of ALT, AST, total cholesterol, LDL-Cholesterol, triglyceride, Leptin were decreased significantly. 4. The levels of creatinine were decreased but did not show significance. 5. The level of HDL-cholesterol and the expression of ${\beta}$3AR mRNA gene in 3T3-L1 Adipocytes were increased significantly. 6. Adipocytes' size was decreased significantly. 7. The expression of ${\beta}$3AR mRNA gene, Leptin mRNA gene and serotinin mRNA gene in Adipocytes tissue was decreased significantly. Conclusion Based on these results, it is proved that SSYBHB is effective on the therapy of obesity by referring to obese-gene and obese inhibitory. So, it is espected that the clinical application of SSYBHB can help the treatment of obesity.

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