The Korean Journal of Food And Nutrition (한국식품영양학회지)

The Korean Society of Food and Nutrition (한국식품영양학회)
권호 표지

Mulberry Fruit Extract Consumption is Inversely Associated with Hyperlipidemia in Middle-aged Men

오디 추출물이 중년 남성의 항고지혈증에 미친 효과

  • Kim, Ae-Jung (Dept. of Food and Nutrition, Chonbuk National University) ;
  • Park, Soo-Jin (Dept. of Food and Nutrition, Hyejeon College) ;
  • Rho, Jeong-Ok (Dept. of Food and Nutrition, Baewha Women's College)
  • Published : 2008.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

In a previous study, a mulberry fruit extract(MFE) supplement exhibited anti-inflammatory activity and improved serum lipid profiles in arthritic rats. The objective of this study was to determine whether dietary MFE could ameliorate inflammatory parameters and serum lipid levels in humans. Twenty-six middle-aged subjects(mean body mass index=27 $kg/m^2$) consumed MFE(100 $m{\ell}/day)$ after lunch for 4 wks. Anthropometric measurements, serum oxidative stress markers and serum lipid profile analyses were performed at baseline and then at 4 wk following the study. There were no significant differences in anthropometric measurements, including BMI, WHR, and body fat composition. After the 4 wk-intervention, serum levels of C-reactive protein(CRP), ferric-reducing ability of plasma(FRAP), serum triglyceride(TG) and LDL-cholesterol had significantly decreased(p<0.05), whereas serum levels of HDL-cholesterol significantly(p<0.05) increased. These findings suggest the consumption of mulberry extract may be protective against inflammation and the atherosclerotic state in elderly obese men at high risk for cardiovascular disease(CVD).

Keywords

References

  1. Cao, G, Russell, RM, Lischner, N and Prior, RL. Serum antioxidant capacity is increased by consumption of strawberries, spinach, red wine, vitamin C in elderly women. J. Nutr. 128:2383-2390. 1998
  2. Korean Newsweek. Colorful fruits are healthy in human body. P 96. December 15th. Seoul, Korea. 1999
  3. Boziian, KA. Mulberry as a medicinal substance. Vopr Pitan. 18:81-82. 1959
  4. Kim, AJ and Park, SJ. Mulberry extract supplements ameliorate the inflammation-related hematological parameters in carrageenan-induced arthritic rats. J. Med. Food. 9:431-435. 2006 https://doi.org/10.1089/jmf.2006.9.431
  5. Kim, HB, Kim, SY, Rhu, KS, Lee, WC and Moon, JY. Effect of methanol extracts from mulberry fruit on the lipid metabolism and liver function in cholesterol-induced hyperlipidemic rats. Kor. J. Seric. Sci. 43:104-108. 2001
  6. Kim, HB, Park, HJ and Lee, WC. Anti-inflammatory and antioxidative effects of Morus spp. fruit extract. Kor. J. Med. Crop Sci. 6:204-209. 1998
  7. Hwang, KH and Kim, YK. Promoting effect and recovery activity from physical stress of the fruit of Morus alba. Biofactors. 21:267-271. 2004 https://doi.org/10.1002/biof.552210152
  8. Yamamoto, J, Naemura, A, Ura, M, Ijiri, Y, Yamashita, T, Kurioka, A and Koyama, A. Testing various fruits for antithrombotic effect: Mulberries. Platelets. 17:555-564. 2006 https://doi.org/10.1080/09537100600759295
  9. Freese, R, Vaarala, O, Turpeinen, AM and Mutanen, M. No difference in platelet activation or inflammation markers after diets rich or poor in vegetables, berries and apple in healthy subjects. Eur. J. Nutr. 43:175-182. 2004 https://doi.org/10.1007/s00394-004-0456-4
  10. Park, HS, Park, CY, Oh, SW and Yoo, HJ. Prevalence of obesity and metabolic syndrome in Korean adults. Obes. Res. 9:104-107. 2008
  11. Fiedewald, WT, Levy, RI and Fredrickson, DS. Estimation of the concentration of low density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin. Chem. 18:499-502. 1972
  12. Reinman, S and Frankel, SA. Colorimetric method for the determination of serum glutamic oxaolaceteic and glutamic pyruvic transaminase. Am. J. Clin. Pathol. 28:56-60. 1957 https://doi.org/10.1093/ajcp/28.1.56
  13. Ohkawa, H, Ohishi, N and Yagi, K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95:351-353. 1979 https://doi.org/10.1016/0003-2697(79)90738-3
  14. Bennzie, IFF and Strain, JJ. The ferric reducing ability of plasma (FRAP) as measure of "Antioxidant Power": The FRAP Assay. Anual Biochem. 239:70-76. 1996 https://doi.org/10.1006/abio.1996.0292
  15. Jee, SH, Sull, JW, Park, J, Lee, SY, Ohrr, H, Guallar, E and Samet, JM. Body-mass index and mortality in Korean men and women. NEJM. 355:779-787. 2006 https://doi.org/10.1056/NEJMoa054017
  16. Rossi, A, Serraino, I, Dugo, P, Di, Paola, R, Mondello, L, Genovese, T, Morabito, D, Dugo, G, Sautebin, L, Caputi, AP and Cuzzocrea, S. Protective effects of anthocyanins from blackberry in a rat model of acute lung inflammation. Free Radical Res. 37:891-900. 2003 https://doi.org/10.1080/1071576031000112690
  17. Takeda, Y, Ichihara, A, Taioka, H and Inove, H. The biochemistry of animal cells, the effect of corticosteroids on leakage of enzyme from dispersed rat liver cell. J. Biol. Chem. 239:3590-3596. 1964
  18. Seoul Clinical Laboratories. Clinical value of Seoul Medical Science Institute, pp.120-128, Seoul Medical Science Institute. Seoul, Korea. 2004
  19. Mazza, G and Miniati, E. Anthocyanins in fruits, vegetables, and grains, pp.1-40. Boca Raton; CRC Press. Florida, USA. 1993
  20. Kuhnau, J. The flavonoids. A class of semi-essential food components: their role in human nutrition. World Rev. Nutr. Diet. 24:117-191. 1976
  21. Hertog, MGL, Hollman, PCH, Katan, MB and Kromhout, D. Intake of potentially anticarcinogenic flavonoids and their determinants in adults in the Netherlands. Nutr. Cancer. 20: 21-29. 1993 https://doi.org/10.1080/01635589309514267
  22. Saltevo, J, Vanhala, M, Kautiainen, H and Laakso, M. Levels of adiponectin, C-reactive protein and interleukin-1 receptor antagonist are associated with the relative change in body mass index between childhood and adulthood. Diab. Vasc. Dis. Res. 4:331-340. 2007