Journal of Haehwa Medicine (혜화의학회지)

Research Institute of Korean Medicine (대전대학교 한의학연구소)
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A Study on Combination of Topical Jachobokhabbang(JBB) and Internal Hwangtogamibang(HTGMB) for the Treatment of Atopic Dermatitis

아토피 피부염에 대한 황토가미방(黃土加味方)과 자초복합방(紫草複合方) 겸용 연구

  • Ha, Yo-Tae (Department of Oriental Pathology, College of Oriental Medicine, Daejeon University) ;
  • Choi, Hak-Joo (Department of Oriental Pathology, College of Oriental Medicine, Daejeon University) ;
  • Gim, Seon-Bin (Department of Oriental Pathology, College of Oriental Medicine, Daejeon University) ;
  • Kim, Dong-Hee (Department of Oriental Pathology, College of Oriental Medicine, Daejeon University)
  • 하여태 (대전대학교 한의과대학 병리학교실) ;
  • 최학주 (대전대학교 한의과대학 병리학교실) ;
  • 김선빈 (대전대학교 한의과대학 병리학교실) ;
  • 김동희 (대전대학교 한의과대학 병리학교실)
  • Published : 2008.12.31
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Abstract

In order to investigate the efficacy of a combination of JBB as topical and HTGMB as internal treatment method, changes in various immune related factors and histological changes in NC/Nga induced animal model was studied. Combined treatment of topical JBB and internal HTGMB significantly reduced the atopic dermatitis clinical index, the number of immune cells such as CD19+, CCR3+, B220+/IgE+, and Gr-1+/CD11b+ in DLN and dorsal skin, compared to the control group. Otherwise increased CD3+, CD4+/CD25+, CD8+ and CD4+ cells in the DLN. And also combined treatment of topical JBB and internal HTGMB suppressed the lymphocytes and mast cells from infiltrating into the skin tissues when stained with H&E and toluidine blue. Based on the results above, it is strongly suggested that the combined treatment of topical JBB and internal HTGMB significantly induced anti-allergic activities through immune modulation. The findings can be applied to developing a more sustainable treatment for atopic dermatitis and be helpful in practicing combined treatments in clinical treatments in the future.

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