The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Inhibitory Effect of Extract of Teucrium veronicoides on the Production of Inflammatory Cytokines

곽향 추출물의 염증성세포활성물질 억제효과

  • Bae, Gi-Sang (Dept. of Herbology, College of Oriental Medicine, Wonkwang Universlty) ;
  • Park, Hee-Je (Dept. of Herbology, College of Oriental Medicine, Wonkwang Universlty) ;
  • Kim, Do-Yun (College of Oriental Pharmacy, Wonkwang University) ;
  • Seo, Sang-Wan (Dept. of Microbiology, College of Medicine, Kyung Hee University) ;
  • Park, Kyung-Bae (College of Oriental Pharmacy, Wonkwang University) ;
  • Kim, Byung-Jin (College of Oriental Pharmacy, Wonkwang University) ;
  • Song, Je-Moon (Dept. of Herbology, College of Oriental Medicine, Wonkwang Universlty) ;
  • Lee, Kyung-Yong (Dept. of Herbology, College of Oriental Medicine, Wonkwang Universlty) ;
  • Na, Chul (Dept. of Oriental Rehabilitation Medicine, IKsan Wonkwang Oriental Hospital) ;
  • Shin, Byung-Chul (Dept. of Oriental Rehabilitation Medicine, IKsan Wonkwang Oriental Hospital) ;
  • Park, Sung-Joo (Dept. of Herbology, College of Oriental Medicine, Wonkwang Universlty) ;
  • Song, Ho-Joon (Dept. of Herbology, College of Oriental Medicine, Wonkwang Universlty) ;
  • Hwang, Sung-Yeon (Dept. of Herbology, College of Oriental Medicine, Wonkwang Universlty)
  • 배기상 (원광대학교 한의과대학 본초학교실) ;
  • 박희제 (원광대학교 한의과대학 본초학교실) ;
  • 김도윤 (원광대학교 약학대학 한약학과) ;
  • 서상완 (경희대학교 의과대학 미생물학교실) ;
  • 박경배 (원광대학교 약학대학 한약학과) ;
  • 김병진 (원광대학교 약학대학 한약학과) ;
  • 송제문 (원광대학교 한의과대학 본초학교실) ;
  • 이경용 (원광대학교 한의과대학 본초학교실) ;
  • 나철 (원광대학교 한방병원 재활의학과) ;
  • 신병철 (원광대학교 한방병원 재활의학과) ;
  • 박성주 (원광대학교 한의과대학 본초학교실) ;
  • 송호준 (원광대학교 한의과대학 본초학교실) ;
  • 황성연 (원광대학교 한의과대학 본초학교실)
  • Published : 2008.09.30
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Abstract

Objectives : The purpose of this paper was to investigate the anti-inflammatory effects of extract from Teucrium veronicoides (TV) on the RAW 264.7 cells. Methods : To evaluate of anti-inflammatory of TV, we examined the cytokine productions on lipopolysacchride (LPS)-induced RAW 264.7 cells and also inhibitory mechanisms using Western blot. Furthermore, We examined LPS-induced endotoxin shock. Results : 1. Extract from TV itself does not have any cytotoxic effect. 2. Extract from TV reduced LPS-induced Nitric oxide (NO),interleukin (IL)-1b, IL-6 and IL-10, tumor necrosis factor-a (TNF-a) production in RAW 264.7 cells. 3. TV inhibited the activation of mitogen-activated protein kinases (MAPKs) such as p38, extracelluar signal-regulated kinase (ERK 1/2) and c-Jun NH2-terminal kinase (JNK) and also the degradation of inhibitory kappa B a (Ik-Ba) in the LPS-stimulated RAW 264.7 cells. 3. TV slightly increased the duration of survival after LPS-induced endotoxin shock. Conclusions : TV down-regulated LPS-induced NO and cytokines production, which could provide a clinical basis for anti-inflammatory properties of TV.

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