The Korea Journal of Herbology (대한본초학회지)
- Volume 23 Issue 3
- /
- Pages.141-147
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- 2008
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- 1229-1765(pISSN)
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- 2288-7199(eISSN)
Immuno-stimulating Effects of Oga-Power (OP) Containing Extract of Acanthopanax sessiliflorus on Immune Cells in Mice
오가피를 활용한 음료인 오가파워가 생쥐의 면역세포 활성화에 미치는 영향
- Kim, Hyung-Woo (Research Center of Industrial Accelerators) ;
-
Kim, Kyung-Yoon
(College of Health and Welfare, Dongshin University)
;
- Lee, Sang-Yeong (College of Korean Medicine, Dongshin University) ;
-
Kim, Gye-Yeop
(College of Health and Welfare, Dongshin University)
;
-
Jeon, Byung-Gwan
(College of Industry, Dongshin University)
;
- Cho, Su-In (School of Oriental Medicine, Pusan National University) ;
-
Jeong, Hyun-Woo
(College of Korean Medicine, Dongshin University)
- 김형우 (산업용가속기이용 생물연구센터) ;
-
김경윤
(동신대학교 보건복지대학)
;
- 이상영 (동신대학교 한의과대학) ;
-
김계엽
(동신대학교 보건복지대학)
;
-
전병관
(동신대학교 공과대학)
;
- 조수인 (부산대학교 한의학전문대학원) ;
-
정현우
(동신대학교 한의과대학)
- Published : 2008.09.30
Abstract
Objectives : The cortex and root of Acanthopanax sessiliflorus (AR), a herbal medicine, have been used for several diseases including cancer in Oriental countries. Recently, we reported that AR has an immune-potentiating action. Oga-Power(OP) was made using extract from AR. For these reasons, we hypothesized that OP can potentiate the immune system in terms of accelerating proliferation rates of immune cells such as thymocytes and splenocytes. Methods : In this experiment, proliferation rates of thymocytes and splenocytes were measured using modified 3-[4,5-dimethy -lthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT). No production levels in macrophages isolated from normal mice were measured using Griess method. Results : In our results, treatment with OP accelerated proliferation rates of splenocytes, but did not affect those of thymocytes in vitro. On the other hand, proliferation rates of thymocytes was elevated in vivo. In addition, level of NO production from macrophage separated from abdominal cavity of normal mice was elevated by treatment with OP. Conclusions : In conclusion, OP has immune-potentiating action, by acceleration of splenocyte proliferation and elevation of NO production level from macrophages.