The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Inhibitory Studies of Hwangryunhaedok-tang on Development of Atopic Dermatitis in NC/Nga Mice

황련해독탕이 NC/Nga Mice에서 유발된 아토피 피부염에 미치는 영향

  • Kim, Bo-Ae (Dept. of Cosmeceutical Science, Daegu Haany University) ;
  • Kim, Mi-So (Dept. of Cosmeceutical Science, Daegu Haany University) ;
  • Kang, Bo-Mi (Dept. of Cosmeceutical Science, Daegu Haany University) ;
  • Byeon, Seon-Hui (Dept. of Cosmeceutical Science, Daegu Haany University) ;
  • Park, Il-Hyang (Dept. of Cosmeceutical Science, Daegu Haany University) ;
  • Park, Ji-Ha (College of Oriental Medicine, Daegu Haany University) ;
  • Jung, Ji-Wook (Dept. of Herbal Medicinal Pharmacology, Daegu Haany University) ;
  • Ahn, Eun-Mi (Dept. of Herbal Foodceutical Science, Daegu Haany University) ;
  • Jung, Hyeon-A (Dept. of Herbal Cuisine&Nutrition, Daegu Haany University) ;
  • Jang, Jung-Hee (College of Oriental Medicine, Daegu Haany University) ;
  • Bae, Won (Miwon Commercial Co, Ltd) ;
  • Lee, Ha-Young (Miwon Commercial Co, Ltd) ;
  • Choi, Phil-Nye (Miwon Commercial Co, Ltd) ;
  • Park, Chan-Ik (Dept. of Cosmeceutical Science, Daegu Haany University)
  • 김보애 (대구한의대학교 화장품약리학과) ;
  • 김미소 (대구한의대학교 화장품약리학과) ;
  • 강보미 (대구한의대학교 화장품약리학과) ;
  • 변선희 (대구한의대학교 화장품약리학과) ;
  • 박일향 (대구한의대학교 화장품약리학과) ;
  • 박지하 (대구한의대학교 한의과대학 한의학과) ;
  • 정지욱 (대구한의대학교 한약재약리학과) ;
  • 안은미 (대구한의대학교 한방식품약리학과) ;
  • 정현아 (대구한의대학교 한방식품조리영양학부) ;
  • 장정희 (대구한의대학교 한의과대학 한의학과) ;
  • 배원 (미원상사(주)) ;
  • 이하영 (미원상사(주)) ;
  • 최필녀 (미원상사(주)) ;
  • 박찬익 (대구한의대학교 화장품약리학과)
  • Published : 2008.06.30
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Abstract

Objectives : HRHDT has been known as a useful prescription with antibiotic, anti-inflammatory, antioxidative and immunosuppressive activity. To evaluate anti-atopic dermatitis effect of HRHDT, we treated HRHDT in NC/Nga mice model skin induced contact hypersensitivity. Methods : Contact hypersensitivity, a local inflammatory response of skin, was induced by spreading the back skin of NC/Nga mice with 0.4${\sim}$1% DNCB. HRHDT was prepared by dissolving 3% HRHDT in solution and treated 3 weeks on the back skin. Results : HRHDT significantly reduced TEWL and erythema by 0.4${\sim}$1% of DNCB treatment compared to control group. HRHDT also reduced IgE on serum obtained from blood of DNCB-treated mice. Conclusions : These results showed that HRHDT could be used as a pharmaceutical material with anti-atopic dermatitis effect by reducing IgE in contact, hypersensitivity atopic dermatitis NC/Nga mice model by DNCB.

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