The Korea Journal of Herbology (대한본초학회지)
- Volume 23 Issue 1
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- Pages.53-61
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- 2008
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- 1229-1765(pISSN)
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- 2288-7199(eISSN)
Effects of Gagambojungikgi-tang on the Immune Mediators Regulation and Wound Healing in the rSj26 or Chemical Antigen induced Atopic Dermatitis Model Mice
rSj26 또는 화학 항원 유도 아토피 피부염 마우스 모델에서 가감보중익기탕의 면역 매개물 조절 및 상처치료 효과
- Heo, Jung-Hun (School of Alternative Medicine & Health Science, College of Alternative Medicine, Jeonju University) ;
- Song, Han-Na (School of Alternative Medicine & Health Science, College of Alternative Medicine, Jeonju University) ;
- Jang, Seon-Il (School of Alternative Medicine & Health Science, College of Alternative Medicine, Jeonju University)
- Published : 2008.03.30
Abstract
Objectives : The aim of this study was to investigative the effects of Gagambojungikgi-tang (GBT), a Korean herbal medicine, on the immune mediators, T cell proliferation and wound healing in the recombinant Sj26 (rSj26) antigen induced atopic dermatitis(AD) model mice. Methods : GBT is the water extracts prepared from mixture of Ginseng Radix, Astragali Radix, Angelicae gigantis Radix, Atractylodes Rhizoma alba, Aurantii nobilis Pericarpium, Glycyrrhizae Radix, Artemisia iwayomogi Herba, Scutellaria Radix, Lonicera japonica Flos. This is a modified prescription of Bojungikgi-tang, which has been used for the treatment of indigestion, and immunological disease in east-asian countries. GBT was orally administered or externally applied at difference doses. The levels of immune mediators [(IgE, IgG1, prostaglandin E2 (PGE2), Th1/Th2 cytokines], T cell proliferation, and wound healing in the rSj26 or chemical antigen induced AD model BALB/c were investigated. Results : GBT dose-dependently suppressed the release of TNF-
Keywords
- Gagambojungikgi-tang;
- rSj26 antigen;
- Chemical antigen;
- Atopic dermatitis (AD);
- Th1/Th2 cytokines;
- Prostaglandin E2;
- Wound healing