The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
권호 표지

Study on the Attributive Channel Theory of Herbal Medicine by the Pharmacodynamic Research of 1-131 Labelled Hesperetin

Hesperetin의 I-131 표지 및 생체(生體) 분포(分布) 분석(分析)을 통한 귀경(歸經) 연구

  • Kim, Sung-Kyu (College of Oriental Medicine, Kyunghee University) ;
  • Ham, In-Hye (College of Oriental Medicine, Kyunghee University) ;
  • Bu, Young-Min (College of Oriental Medicine, Kyunghee University) ;
  • Kim, Ho-Cheol (College of Oriental Medicine, Kyunghee University) ;
  • Cho, Jung-Hyuck (Medicinal Chemistry Research Center, Korea Institute of Science and Technology) ;
  • Choi, Ho-Young (College of Oriental Medicine, Kyunghee University)
  • 김성규 (경희대학교 한의과대학) ;
  • 함인혜 (경희대학교 한의과대학) ;
  • 부영민 (경희대학교 한의과대학) ;
  • 김호철 (경희대학교 한의과대학) ;
  • 조정혁 (한국과학기술연구원 의약화학연구센터) ;
  • 최호영 (경희대학교 한의과대학)
  • Published : 2008.03.30
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Abstract

Objectives : This study was to verify the Attributive Channel theory of herbal medicine. Methods : [$^{131}I$]iodohesperetin was synthesized, separated, and refined from hesperetin, the major component of Citrus species, followed by observing the biodistribution in an organism of C57 BL/6 mice with and without Lewis Lung Carcinoma. Results : Iodohesperetin 27.5 mg was obtained through column cliromatography after a reaction with 50 mg of Hesperitin and 8 mg of Nal. The radiochemical yield of [$^{131}I$]iodohesperetin synthesis was 25 % when checked with Radio TLC chromatography. [131I]iodohesperetin was most largely distributed in the stomach, lung and liver of C57BL/6 mouse. The highest %ID/g in stomach was 40 min, in lung and liver was 20 min after injection. The % ID/g of tumor tissue was comparable with that of blood. Conclusions : The fact that [$^{131}I$]iodocurcumin was most largely distributed in the stomach, lung and liver was related with the Attributive Channel theory. And there was no significant finding related to tumor cells.

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