Food Science and Biotechnology

Korean Society of Food Science and Technology (한국식품과학회)
권호 표지

Evaluation of S-Adenosyl-L-Methionine Production by Bifidobacterium bifidum BGN4

  • Kim, Ji-Youn (Department of Food and Nutrition, Research Institute of Human Ecology, Seoul National University) ;
  • Suh, Joo-Won (Myongji University) ;
  • Ji, Geun-Eog (Department of Food and Nutrition, Research Institute of Human Ecology, Seoul National University)
  • Published : 2008.02.29
Download PDF
⟨ Previous Next ⟩

Abstract

S-Adenosyl-L-methionine (SAM) is an important metabolic intermediate in living organisms and participates in many reactions as a methyl group donor. SAM has been used as a dietary supplement and is proposed to have beneficial effects on the liver and brain. The aim of this study was to find lactic acid bacteria with high SAM-producing ability to be used as SAM enhancing probiotics. We used high performance liquid chromatography (HPLC) to quantify the amount of SAM produced, and found that Bifidobacterium bifidum BGN4 produced a significantly higher amount of SAM than other Bifidobacterium or Lactobacillus strains. The effect of various carbon and nitrogen sources on SAM production was examined. This study confirmed that Bifidobacterium may be utilized as a source of SAM in the functional food industry.

Keywords

References

  1. Mutai M. Characteristics of 'Mil-Mil', a Bifidobacterium-fermented milk. New Food Ind. 20: 17-20 (1978)
  2. Hughes DB, Hoover DG. Bifidobacteria: Their potential for use in American dairy products. Food Technol.-Chicago 45: 64-83 (1991)
  3. Kim HS. Characterization of lactobacilli and bifidobacteria as applied to dietary adjuncts. Cult. Dairy Prod. J. 23: 6-9 (1988)
  4. Jayaprakasha HM, Yoon YC, Paik HD. Probiotic functional dairy foods and health claims: An overview. Food Sci. Biotechnol. 14: 523-528 (2005)
  5. Lee CH. Lactic acid fermented foods and their benefits in Asia. Food Sci. Biotechnol. 8: 259-269 (1997)
  6. Parvez S, Malik KA, Kang SA, Kim HY. Probiotics and their fermented food products are beneficial for health. J. Appl. Micorbiol. 100: 1171-1185 (2006) https://doi.org/10.1111/j.1365-2672.2006.02963.x
  7. Cantoni GL. S-Adenosylmethionine: A new intermediate formed enzymatically from L-methionine and adenosine triphosphate. J. Biol. Chem. 204: 403-416 (1953)
  8. Lu SC. S-Adenosyl-methionine. Int. J. Biochem. Cell. B. 32: 391- 395 (2000) https://doi.org/10.1016/S1357-2725(99)00139-9
  9. Baldessarini RJ. Neuropharmacology of S-adenosyl-L-methionine. Am. J. Med. 83: 95-105 (1987)
  10. Chiang PK, Gordon RK, Tal J, Zeng GC, Doctor BP, Pardhasaradhi K, McCann PP. S-Adenosylmethionine and methylation. FASEB J. 10: 471-480 (1996) https://doi.org/10.1096/fasebj.10.4.8647346
  11. Friedel HA, Goa KL, Benfield P. S-Adenosyl-L-methionine. A review of its pharmacological properties and therapeutic potential in liver dysfunction and affective disorders in relation to its physiological role in cell membranes. Drugs 38: 389-416 (1989) https://doi.org/10.2165/00003495-198938030-00004
  12. Bradley JD, Flusser D, Katz BP, Schumacher HR, Brandt KD, Chambers MA, Zonay LJ. A randomized double blind, placebo controlled trial of intravenous loading with S-adenosylmethionine (SAM) followed by oral SAMe therapy in patients with knee osteoarthritis. J. Rheumatol. 21: 905-911 (1994)
  13. Purohit V, Russo D. Role of S-adenosyl-L-methionine in the treatment of alcoholic liver disease: Introduction and summary of the symposium. Alcohol 27: 151-154 (2002) https://doi.org/10.1016/S0741-8329(02)00232-X
  14. Kaye GL, Blake JC, Burroughs AK. Metabolism of exogenous Sadenosyl- L-methionine in patients with liver disease. Drugs 40: 124- 128 (1990) https://doi.org/10.2165/00003495-199000403-00012
  15. Lieber CS. S-Adenosyl-L-methionine: Its role in the treatment of liver disorders. Am. J. Clin. Nutr. 76: 1183-1187 (2002) https://doi.org/10.1093/ajcn/76.5.1183S
  16. Gatto G, Caleri D, Michelacci S, Sicuteri F. Analgesizing effect of a methyl donor (S-adenosylmethionine) in migraine: An open clinical trial. Int. J. Clin. Pharm. 6: 15-17 (1986)
  17. Agnoli A, Andreoli V, Casacchia M, Cerbo R. Effect of S-adenosyl- L-methionine (SAMe) upon depressive symptoms. J. Psychiat. Res. 13: 43-54 (1976) https://doi.org/10.1016/0022-3956(76)90008-X
  18. Janicak PG, Lipinski J, Davis JM, Comaty JE, Waternaux C, Cohen B, Altman E, Sharma RP. S-Adenosylmethionine in depression. A literature review and preliminary report. Ala. J. Med. Sci. 25: 306- 313 (1988)
  19. Jacobsen S, Danneskiold-Samsoe B, Andersen RB. Oral Sadenosylmethionine in primary fibromyalgia: Double-blind clinical evaluation. Scand. J. Rheumatol. 20: 294-302 (1991) https://doi.org/10.3109/03009749109096803
  20. Bottiglieri T, Godfrey P, Flynn T, Carney MW, Toone BK, Reynolds EH. Cerebrospinal fluid S-adenosylmethionine in depression and dementia: Effects of treatment with parenteral and oral S-adenosylmethionine. J. Neurol. Neurosurg. Ps. 53: 1096-1098 (1990) https://doi.org/10.1136/jnnp.53.12.1096
  21. Alarcon RD, Tolbert LC, Monti JA, Morere DA, Walter-Ryan WG, Kemp B, Smythie JR. One-carbon metabolism disturbances in affective disorders. A preliminary report. J. Affect. Disorders 9: 297-301 (1985) https://doi.org/10.1016/0165-0327(85)90060-6
  22. Bottigliere T, Hyland K, Reynolds EH. The clinical potential of ademetionine (S-adenosylmethionine) in neurological disorders. Drugs 48: 137-152 (1994) https://doi.org/10.2165/00003495-199448020-00002
  23. You HJ, Oh DK, Ji GE. Anticancerogenic effect of a novel chiroinositol- containing polysaccharide from Bifidobacterium bifidum BGN4. FEMS Microbiol. Lett. 240: 131-136 (2004) https://doi.org/10.1016/j.femsle.2004.09.020
  24. Alvarez-Olmos MI, Oberhelman RA. Probiotic agents and infectious diseases: A modern perspective on a traditional therapy. Clin. Infect. Dis. 32: 1567-1576 (2001) https://doi.org/10.1086/320518
  25. Payne SH, Ames BN. A procedure for rapid extraction and highpressure liquid chromatographic separation of the nucleotides and other small molecules from bacterial cells. Anal. Biochem. 123: 151-161 (1982) https://doi.org/10.1016/0003-2697(82)90636-4
  26. Lee SY, Oh SK, Park SW, Jeon GR, Kim JY, Youn SY, Ji GE. Evaluation of anti-allergic effect of bifidobacteria in murine model of peanut allergy. Pediatr. Allergy Respir. Dis. 16: 131-141 (2006)
  27. Rhee JN, Lyoo YW, Choi MU. Laboratory scale preparation of Sadenosyl- L-methionine from yeast. Korean J. Appl. Microbiol. Biotechnol. 19: 588-591 (1991)
  28. Kim H, Kwack K, Kim DY, Ji GE. Oral probiotic bacterial administration suppressed allergic responses in an ovalbumin-induced allergy mouse model. FEMS Immunol. Med. Mic. 45: 259-267 (2005) https://doi.org/10.1016/j.femsim.2005.05.005