Korean Journal of Poultry Science (한국가금학회지)

The Korean Society of Poultry Science (한국가금학회)
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Infection and Pathogenesis Mechanisms of Marek's Disease Virus

마렉병 바이러스 감염과 병원성 발현 기전

  • Jang, H.K. (Department of Infectious Diseases and Avian Diseases, College of Veterinary.Medicine, Chonbuk National University) ;
  • Park, Y.M. (Department of Infectious Diseases and Avian Diseases, College of Veterinary.Medicine, Chonbuk National University) ;
  • Cha, S.Y. (Department of Infectious Diseases and Avian Diseases, College of Veterinary.Medicine, Chonbuk National University) ;
  • Park, J.B. (Department of Infectious Diseases and Avian Diseases, College of Veterinary.Medicine, Chonbuk National University)
  • 장형관 (전북대학교 수의과대학 전염병학.조류질병학연구실) ;
  • 박영명 (전북대학교 수의과대학 전염병학.조류질병학연구실) ;
  • 차세연 (전북대학교 수의과대학 전염병학.조류질병학연구실) ;
  • 박종범 (전북대학교 수의과대학 전염병학.조류질병학연구실)
  • Published : 2008.03.31
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Abstract

Like the other herpesviruses, the virion of MDV consists of an envelope, which surrounds an amorphous tegument. Within the tegument, and icosahedral capsid encloses a linear double-stranded DNA core. Although the genome structure of MDV indicates that it is an ${\alpha}-herpesvirus$ like herpes simplex and varicella-zoster viruses, biological properties indicate MDV is more akin to the ${\gamma}-herpesvirus$ group, which includes Epstein-Barr and Kaposi's sarcoma herpesviruses. These herpesviruses replicate lytically in lymphocytes, epithelial and fibroblastic cells, and persist in lymphoblastoid cells. MDV has a complex life cycle and uses two means of replication, productive and non-productive, to exist and propagate. The method of reproduction changes according to a defined pattern depending on changes in virus-cell interactions at different stages of the disease, and in different tissues. Productive (lytic) interactions involve active invasion and take-over of the host cell, resulting in the production of infectious progeny virions. However, some herpesviruses, including MDV, can also establish a non-productive (abortive) infection in certain cell types, resulting in production of cell-associated progeny virus. Non-productive interactions represent persistent infection, in which the viral genome is present but gene expression is limited, there is no structural or regulatory gene translation, no replication, no release of progeny virions and no cell death. Reactivation of the virus is rare, and usually the infectious virus can be re-isolated only after cultivation in vitro. MDV establishes latency in lymphoid cells, some of which are subsequently transformed. In this review article, recent knowledges of the pathogenesis mechanisms followed by MDV infection to sensitive cells and chickens are discussed precisely.

Keywords

References

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