Chemical Risk Factors for Children's Health and Research Strategy

어린이 건강관련 유해물질 연구방향

  • Lee, Hyo-Min (Risk Management Research Division, National institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Jung, Ki-Hwa (College of Pharmacy, Duksung Women's University)
  • 이효민 (식품의약품안전청 국립독성과학원 위해관리기술연구과) ;
  • 정기화 (덕성여자대학교 약학대학)
  • Published : 2008.09.30

Abstract

To provide the research strategy for protection of children's health from hazardous chemical, we reviewed the hazardous chemicals can be exposed through maternity, children's life style and living environment. Recently, diseases related with children's living condition were focused as asthma, atopy, childhood developmental disability, congenital malformations and obesity. Children can be exposed to hazardous chemicals through an ambient air, water, soil, food, toys and other factors such as floor dust. Also children's health was deeply related with a wrong life style and neglectful caring by a lack of knowledge and information of harmful ones at parents and child care center's nursers. According to the previous study, the chemical risk factor of children's health were identified as inorganic arsenic, bisphenol A, 2,4-D, dichlorvos, methylmercury, PCBs, pesticide, phthalates, PFOA/PFOS, vinyl chloride, et al. Domestic studies for identification of causality between children exposure to chemicals and resulted hazardous effects were not implemented. The confirmation of chemical risk factors through simultaneously performing toxicological analysis, human effect study, environmental/human monitoring, and risk assessment is needed for good risk management. And also, inter-agency collaboration and sharing information can support confirming scientific evidence and good decision making.

국내 외 선행연구결과에 의한 어린이 출생 전 후 건강에 영향을 미칠 수 있는 주요 유해물질은 inorganic arsenic, BPA, 2,4-D, dichlorvos, methylmercury, PCBs, pesticide, phthalate, PFOA/PFOS, vinyl chloride 등으로서 국내에서도 이들을 포함한 확인 연구가 수행되어져야 할 것이다. 또한 어린이들의 행동발달과 연관된 생활환경에서의 다양한 인체노출이 확인됨에 따라 탁아소, 유치원과 같은 경우 어린이 활동공간을 대상으로 환경모니터링 및 위해관리활동도 병행되어야 할 것이다. 또한 어린이 건강에 영향을 미치는 유해물질을 중심으로 독성평가, 인체영향연구, 환경 및 인체모니터링과 위해평가를 수행하므로 유해물질의 원인-상관관계를 확인하고 사실자료에 근거한 관리정책을 반영하는 것이 바람직하다.

Keywords

References

  1. U.S. Toxicity and Exposure Assessment for Children's Health http://www.epa.gov/teach/
  2. U.S. Environmental Protection Agency (U.S.EPA): Office of Research and Development strategy for research on risks to children. Office of Research and Development, Science Council Review Draft. (1997)
  3. U.S. Agency for Toxic Substances and Diseases (ATSDR): Toxicological Profile for Aresenic. ATSDR (2005)
  4. U.S.EPA: Technology Transfer Network Air Toxics Web Site: Arsenic Compounds. (2000)
  5. U.S.EPA, Toxicity and Exposure Assessment for Children's Health (TEACH): Inorganic Arsenic TEACH Chemical summary. U.S. EPA, TEACH (2007)
  6. WHO, International Agency for Research on Cancer (IARC): IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. IARC 84 (2004)
  7. Bisphenol A Information & Resources http://www.bisphenol-a.org (2007)
  8. 박종세 등: 내분비계장애물질의 위해성분석을 통한 관리 경제성 연구. 식품의약품안전청 (2005)
  9. Wilson, N.K., Chuang, J.C., Lyu, C., Menton, R. and Morgan, M.K.: Aggregate exposures of nine preschool children to persistent organic pollutants at day care and at home. J expo Anal Environ Epidemiol 13 pp. 187-202 (2003) https://doi.org/10.1038/sj.jea.7500270
  10. Roy, D., Palangat, M., Chen, C-W., Thomas, R.D., Colerangel, J., Atkinson, a. and Yan, Z-J.: Biochemical and molecular changes at the cellular level in response to exposure to environmental estrogen-like chemicals. J Toxicology and Environmental Health 50(1) pp.1-30 (1997) https://doi.org/10.1080/009841097160573
  11. 고광락 등: Bipsphenol A (BPA)에 의해 야기되는 생식세포 이상 영향 연구. 식품의약품안전청 (2005)
  12. 장춘곤 등: 내분비계장애물질과 관련이 의심되는 인간질병 또는 현상에 관한 연구(B)-내분비계장애물질과 주의력결핍과잉행동장애 및 학습장애와의 연관성. 식품의약품안전청 (2006)
  13. 품목별 농약등록 현황조치 http://epmso.rda.go.kr/homepage/hp_pumok_item_list.asp
  14. U.S.EPA, TEACH. 2,4-Dichlorophenoxyacetic Acid(2,4-D) TEACH Chemical summary. U.S.EPA, TEACH (2007)
  15. Nancy, K.W., Jane, C.C. and Christopher, L.: Levels of persist organic pollutants in several child day care centers. J of Exposure Analysis and Environmental Epidemiology 11 pp. 449-458 (2001) https://doi.org/10.1038/sj.jea.7500190
  16. U.S.EPA, TEACH: Dichlorvos TEACH Chemical summary. U.S. EPA, TEACH (2007)
  17. 식품의약품안전청 유해물질관리단 위해관리팀, 식품 중 메틸수은 이란?, 식품의약품안전청 (2007)
  18. U.S.EPA, TEACH: Organic Mercury TEACH Chemical Summary. U.S.EPA, TEACH (2007)
  19. Zalazowski, A.J., Piotrowski, J.K.: Mercury Binding, Cooper-Zinc Protein from Rat kidney Amino Acid Composition, Molecular weight and Metal Content. Biochem biophy Act 625 pp. 89-99 (1980) https://doi.org/10.1016/0005-2795(80)90111-7
  20. Wikipedia http://en.wikipedia.org/wiki/Perfluorooctanoic_acid
  21. Geary, W. O., David C.M., William K.R., Mark E.E., David, J.E., John, L.B. and Larry, R.Z.: Preliminary evidence of a decline in perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) concentrations in American Red Cross blood donors. chemosphere 68 pp. 105-111 (2007) https://doi.org/10.1016/j.chemosphere.2006.12.031
  22. Wikipedia http://www.pollutioninpeople.org/toxics/pfds
  23. David, T., Lea, H., Matthias, H., Martin, H., Ian, T.C. and Konrad, H.: Estimating Consumer Exposure to PFOS and PFOA. Risk Analysis 28(2) pp. 251-269 (2008) https://doi.org/10.1111/j.1539-6924.2008.01017.x
  24. Apelberg, B.J., Goldman, L.R., Calafat, A.M., Herbstman, J.B., Kuklenyik, Z., Heidler, J., Needham, L.L., Halden, R.U. and Witter, F.R.: Determinants of fetal exposure to polyfluoroalkyl compounds in Baltimore, Maryland. Environ Sci Technol 41(11) pp. 3891-3897 (2007) https://doi.org/10.1021/es0700911
  25. Silvia, F., M.Teresa, C., Judit, R., Paoma, V. and Jose, L.D.: Interaction in developmental toxicology: Concurrent exposure to perfluorooctane sulfonate (PFOS) and stress in pregnant mice. Toxicology Letters 164 pp. 81-89 (2006) https://doi.org/10.1016/j.toxlet.2005.11.013
  26. 이병무 등: 프탈레이트류 안전관리 방안수립. 식품의약품안전청 (2004)
  27. Carl, G.B., Jan, S., Charles, J.W., Torben, S., Bjorn, L., Mikael, H. and Linda, H.E.: The Association between Asthma and Allergic Symptoms in Children and Phthalates in House Dust: A Nested Case-Control Study. Environmental Health Perspectives 112(14) pp. 1393-1397 (2004) https://doi.org/10.1289/ehp.7187
  28. Leif, O., Lars, G.H. and Jorgen, O.M.: Residential Exposure to Plasticizers and Its Possible Role in the Pathogenesis of Asthma. Environmental Health Perspectives 105(9) pp. 972-978 (1997) https://doi.org/10.2307/3433878
  29. U.S. EPA, TEACH, Phthalates TEACH Chemical Summary, U.S. EPA. (2007)
  30. Bernard, W, Sherlit, A and Rovert W.A.: Pesticides. OJ of the American Academy of Pediatrics 113 pp.1030-1036 (2004)
  31. Claire, I.R. and Scott, W.: Pesticides and Childhood Cancer: An Update of Zahm and Ward's 1998 Review. J Toxicology and Environmental Health, Part B 10 pp. 81-99 (2007) https://doi.org/10.1080/10937400601034589
  32. Keifer, M.C. and Mahurin, R.K.: Chronic neurologic effects of pesticide overexposure. Occup Med 12(2) pp. 291-304 (1997)
  33. Hanke, W. and Jurewicz, J.: The risk of adverse reproductive and developmental disorders due to occupational pesticide exposure: an overview of current epidemiological evidence. Int J Occup Med Environ Health 17(2) pp. 223-243 (2004)
  34. Kofman, O., Berger, A., Massarwa, A., Friedman, A. and Jaffar, A.A.: Motor inhibition and learning impairments in school-aged children following exposure to organophosphate pesticides in infancy. Pediatr Res 60(1) pp. 88-92 (2006) https://doi.org/10.1203/01.pdr.0000219467.47013.35
  35. Pierre, E.: Pesticide Exposure and Asthma. American J of Respiratory and critical care medicine 165 pp. 563-564 (2002) https://doi.org/10.1164/ajrccm.165.5.2201001c
  36. Matias, T., Jordi, S., Raquel, G., Jessica, H., Maria, V.I., Carme, P., Oriol, V., Josep, M.A., Anthony, J.NT. and Paul, C.: Early-life allergen exposure and atopy, asthma, and wheeze up to 6 years of age. American J of Respiratory and critical care medicine 176 pp. 116-453 (2007)
  37. Muhamad, T.S., Uu-Fen, L., Bryan, L. and Frank, D.G.: Early-life environmental risk factors for asthma: findings from the children's health study. environmental health perspectives 112(6) pp. 760-765 (2004) https://doi.org/10.1289/ehp.6662
  38. Ritter, L., Solomon, K.R. and Forget, J.: Persistent Organic Pollutants An Assessment report on: DDT-Aldrin-Dieldrin-Endrin-Chlordane-Hepatachlor-Hexachlorobenzene-Mirex-Toxaphene-PCBs- Dioxins and Furans. IPCS within the framework of IOMC (1998)
  39. Yasunobu, A.: Polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins, and Polychlorinated Dibenzofurans as Encocrine Disrupters-What We Have Learned from Yusho Disease. Environ Res 83 pp. 2-11, (2001)
  40. PCBs baby Studies Part 1 http://www.foxriverwatch.com/baby_studies_pcbs_1.html
  41. Jacobson, J.L. and Jacobson, S.W.: Association of prenatal exposure to an environmental contaminant with intellectual function in childhood. J Toxicol Clin Toxicol 40(4) pp. 467-75 (2002) https://doi.org/10.1081/CLT-120006749
  42. Alan, A., Brian, L. G., Margaret, D.S. and Erica, W.: Identifying and managing adverse environmental health effects: 5.Persistent organic pollutants. CMAJ 166(12), pp. 1549-1554 (2002)
  43. 신종철 등: 선천성기형 모니터링 체계 구축을 위한 다기관 공동연구-선천성기형과 PCBs와의 상관성 연구. 식품의약품안전청 (2007)
  44. WHO, IARC,: IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. IARC Supplement 7 pp. 373 (1987)
  45. U.S.EPA, TEACH: Vinyl Chloride (VC) TEACH Chemical summary. U.S.EPA, TEACH (2007)
  46. Theriault, G, Iturra, H. and Gingras, S.: Evaluation of the association between birth defects and exposure to ambient vinyl chloride. Teratology 27(3) pp.359-370 (1983) https://doi.org/10.1002/tera.1420270310
  47. ATSDR: Toxicological Profile for Vinyl Chloride. ATSDR (2006)