The Korean Journal of Food And Nutrition (한국식품영양학회지)

The Korean Society of Food and Nutrition (한국식품영양학회)
권호 표지

The Effects of Caffeine on Lipid and Mineral Content in the Serum of Rats

카페인 섭취가 흰쥐의 혈청내 지질과 무기질 함량에 미치는 영향

  • Kim, Myung-Hee (Dept. of Food and Nutrition, Kongju National University) ;
  • Kim, Yong-Ran (Dept. of Food and Nutrition, Kongju National University) ;
  • Lee, Jong-Wan (Dept. of Animal Resources Science, Kongju National University) ;
  • Park, Byung-Kwon (Dept. of Companion & Laboratory Animal Science, Kongju National University) ;
  • Kim, Min-Kyu (Dept. of Animal Science and Biotechnology, Chungnam National University) ;
  • Choi, Mi-Kyeong (Dept. of Food and Nutrition, Chungwoon University) ;
  • Kim, Ae-Jung (Dept. of Food and Nutrition, Hyejeon College)
  • Published : 2008.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

This study was conducted to investigate the effects of caffeine on lipid and mineral content in the serum of rats given a caffeine free diet(FC), a low caffeine diet(LC), a medium caffeine diet(MC), a high caffeine diet(HC) or a super-high caffeine diet(SHC) for 5 weeks. Thirty male Sprague-Dawley rats(body weight, $110{\pm}0.3$ g) were blocked into 5 groups and fed diets with or without pure caffeine. Caffeine intake models showed a lower mean-weight gain, food intake and food efficiency in the high caffeine diet groups(MC, HC and SHC groups) than the groups receiving a caffeine free or low caffeine diet(FC and LC groups). Serum total lipid, total cholesterol and LDL-cholesterol levels decreased, but the serum HDL-cholesterol level increased according to the increase in caffeine intake. Serum total lipid, HDL-cholesterol and serum triglyceride were significantly lower in the HC and SHC groups than the FC group. All of the serum minerals decreased as caffeine intake increased. Serum iron, calcium, magnesium and phosphorus significantly decreased in the HC and SHC groups compared to the FC group. Caffeine intake was associated with less weight gain and reduced serum total cholesterol, triglyceride and total lipid. The results suggest that rats fed high amounts of caffeine may be susceptible to osteoporosis due to their low levels of calcium, magnesium and phosphorus.

Keywords

References

  1. 한국식품영양학회편. 식품영양학사전, pp.88-89. 한국사전연구사. 용인. 한국. 1998
  2. Acheson, KJ, Markiewicz, BZ, Anantharaman, K and Jequier, E. Caffeine and coffee-their influence on metabolic rate and substrate utilization in normal weight and obese individuls. Am. J. Clin. Nutr. 33:989-997 .1980 https://doi.org/10.1093/ajcn/33.5.989
  3. Leblanc, J, Jobin, M, Cote, J, Samson, P and Labrie, A. Enhanced metabolic response to caffeine in exercise-trained human subjects. J. Appl. Physiol. 59:832-837. 1985 https://doi.org/10.1152/jappl.1985.59.3.832
  4. Debas, HT, Cohen, MM, Holubitsky, IB and Harrison, RC. Caffeine stimulated gastric acid and pepsin secretion. Scand. J. Gastroentol. 6:453-457. 1971 https://doi.org/10.3109/00365527109180725
  5. McCarty, MF. A chlorogenic acid-induced increase in GLP-1 production may mediate the impact of heavy coffee consumption on diabetes risk. Medical Hypothese. 64:848-853. 2005 https://doi.org/10.1016/j.mehy.2004.03.037
  6. Thong, FS and Graham, TE. Caffeine-induced impairment of glucose tolerance is abolished by beta-adrenergic receptor blockade in humans. J. Appl. Physiol. 92:2347-52. 2002 https://doi.org/10.1152/japplphysiol.01229.2001
  7. Van Dam, RM and Hu, FB. Coffee consumption and risk of type 2 diabetes, A systematic review. JAMA. 297:97-104. 2005
  8. James, AG, Carol NB and Allan, G. Coffee, diabetes, and weight control. Am J. Clin. Nutr. 84:682-693. 2006 https://doi.org/10.1093/ajcn/84.4.682
  9. Lecos, CW. Caffeine jitters: Some safety questions remain, pp.13-16. FDA. Consumer Dec. Rockville. USA. 1987
  10. Little, JA, Shanoff, HM and Csima, A. Coffee and serum lipids in coronary heart disease. The Lancet. 2:732-734. 1966
  11. Thelle, DS, Arnesen, E and Forde, OH. The tromso heart study. New Engl. J. Med. 308:1454-1457. 1983 https://doi.org/10.1056/NEJM198306163082405
  12. Shirlow, MJ and Mathers, CD. Caffeine consumption and serum cholesterol levels. Intern. J. Epidemiol. 13:422-426. 1984 https://doi.org/10.1093/ije/13.4.422
  13. Arnesen, E, Fordem OH and Thelle, DS. Coffee and serum cholesterol. Br. Med. J. 288:1960-1972.1984
  14. Firde, OH, Knutsen, SF, Arnesen, E and Thellem, DS. The tromso heart study. Br. Med. J. 280:893-895. 1985
  15. Dawber, TR, Kannel, WB and Gorden, T. Influences of caffeinedrinking on the coronary heart disease in the rat. New Engl. J. Med. 291:871-880. 1974 https://doi.org/10.1056/NEJM197410242911703
  16. Heyden, S, Heiss, G, Manegold, C, Tyroler, HA, Hames, CG, Bartel, AG and Cooper, G. The combined effect of smoking and coffee drinking on LDL and HDL cholesterol. Circulation. 60:22-25. 1979 https://doi.org/10.1161/01.CIR.60.1.22
  17. Yeh, JK, Aloia, JF, Semla, HM and Chen, SY. Influence of injected caffeine on the metabolism of calcium and the retention and excretion of sodium, phosphorus, magnesium, zinc and copper in rats. J. Nutr. 116:273-286. 1986 https://doi.org/10.1093/jn/116.2.273
  18. Massey, LK and Hollingbery, PW. Acute effects of dietary caffeine and sucrose on urinary mineral excretion of healthy adolescents. Nutr. Res. 8:1005-1011. 1988 https://doi.org/10.1016/S0271-5317(88)80055-1
  19. Massey, LK and Wise, KL. The effect of dietary caffeine on urinary excretion of calcium, magnesium, sodium and potassium in health young females. Nutr. Res. 4:43-51. 1984 https://doi.org/10.1016/S0271-5317(84)80132-3
  20. Whiting, SJ and Whutney, HL. Effect of dietary caffeine and theophylline on urinary calcium excretion in the adult rat. J. Nutr. 117:1224-1232.1987 https://doi.org/10.1093/jn/117.7.1224
  21. Yano, K, Heilbrun, LK, Wasnich, RD, Hankin, JH and Vogel, JM. The relationship between diet and bone mineral content of multiple skeletal sites in elderly Japaneses-American men and women living in Hawaii. Am. J. Clin Nutr. 42:877-888. 1985 https://doi.org/10.1093/ajcn/42.5.877
  22. Munoz, L, Keen, CL, Lonnerdal, B and Dewey, K. Coffee intake during pregnancy and lactation in rats. Maternal and pup hematological parameters and liver iron, zinc and copper concentration. J. Nutr. 116:1326-1340. 1986 https://doi.org/10.1093/jn/116.7.1326
  23. Aranda, JV, Collinge, JM, Zimman, R, Trippenback, T and Jain, R. Maturation of caffeine desposition in infancy. Clin. Res. 25:674-680.1977
  24. Aldrige, A, Aranda, JV and Neins, AH. Caffeine metabolism in the newborn. Clin. Pharmacol. Ther. 25:447-452. 1973
  25. Wilhelmsen, L, Tibblin, G, Elmfeldt, D, Wedel, H and Werko, L. Coffee consumption and coronary heart disease in middle aged Swedish men. Acta. Med. Scand. 201:547-552. 1977 https://doi.org/10.1111/j.0954-6820.1977.tb15745.x
  26. AIN-93G Growth Purified Diet. www.testdiet.com
  27. Westerterp-Plantenga, MS, Lejeune, MPGM and Kovacs, EMR. Body weight loss and weight maintenance in relation to habitual caffeine intake and green tea supplementation. Obes. Res. 13:1195-1204. 2005 https://doi.org/10.1038/oby.2005.142
  28. Kovacs, EMR, Lejeune, MPGM, Nijs, I and Westerterp- Plantenga, MS. Effects of green tea on weight maintenance after body-weight loss. Br. J. Nutr. 91:431-437. 2004 https://doi.org/10.1079/BJN20041061
  29. Bai, HS, Lee, SK and Ahn, HS. Effect of caffeine on lipid metabolism in the rats fed with different levels of dietary lipids. Sungshin W U. BSRI. J. BS. 4:43-53.1987
  30. Esther, LG, Rob, MVD, Swapnil, R, Walter, CW, Joann, EM and Frank, BH. Changes in caffeine intake and long-term weight change in men and women. Am. J. Clin. Nutr. 83: 674-680. 2006 https://doi.org/10.1093/ajcn.83.3.674
  31. Bukowiecki, LJ, Lupien, J, Follea, N and Jahjah, L. Effects of sucrose, caffeine and cola beverages on obesity, cold resistance, and adipose tissue cellularity. Am. J. Physiol. 244: 500-507. 1983
  32. Fears, R. The hypercholesterolemic effect of caffeine in rats fed on diets with and without supplementary cholesterol. Br. J. Nutr. 39:363-370. 1978 https://doi.org/10.1079/BJN19780046
  33. Boothby, WM and Rowntree, LG. Drugs and basal metabolism. J. Pharmacol. Exptl. Therap. 22: 99.1924
  34. Naismith, DJ, Akinjanju, PA and Yudkin, J. Influence of caffeine containing beverages on the growth, food utilization and plasma lipids of the rat. J. Nutr. 97:375. 1968
  35. Nakamoto, T and Shaye, R. Effects of caffeine on the growth of mandible and long bone in protein-energy malnourished newborn rats. Proc. Soc. Exp. Biol. Med. 177 :56-61. 1984
  36. Dulloo, AG, Duret, C, Rohrer, D and et al. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-hr energy expenditure and fat oxidation in humans. Am. J. Clin. Nutr. 70:1040-1045. 1999 https://doi.org/10.1093/ajcn/70.6.1040
  37. Akinyanju, P and Yudkin, J. Effect of coffee and tea on serum lipids in the rat. Nature. 214:426-427. 1967
  38. Cuno, SPM, Uiterwaal, WM, Monique, V, H, Bas, BDM, Marga, O and et al. Coffee intake and incidence of hypertension. Am. J. Clin. Nutr. 85:718-723. 2007 https://doi.org/10.1093/ajcn/85.3.718
  39. Lee, HW. A study on caffeine containing foods and the effect of caffeine in humans. Culinary Research. 6:343-355. 2000
  40. Petito, SL and Evans, JL. Calcium status of the growing rats as affected by diet acidity from ammonium chloride, phosphate and protein. J. Nutr. 114:1049-1059. 1984 https://doi.org/10.1093/jn/114.6.1049
  41. Choi, MK, Jun, YS and Sung, CJ. Effects of caffeine and calcium intake on calcium utilization in female rats of different age. Kor. J. Nutr. 30:1160-1169. 1997