Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effect of Hyeonsamdansameum on Hypertensive Rat Induced Monocrotaline

현삼단삼음(玄蔘丹蔘飮)이 Monocrotaline으로 유발된 고혈압 흰쥐에 미치는 영향

  • Kang, Cheol-Sik (Department of Internal Medicine, College of Oriental Medicine, Dongshin University) ;
  • Jeon, Sang-Yun (Department of Internal Medicine, College of Oriental Medicine, Dongshin University) ;
  • Hong, Seok (Department of Internal Medicine, College of Oriental Medicine, Dongshin University)
  • 강철식 (동신대학교 한의과대학 내과학교실) ;
  • 전상윤 (동신대학교 한의과대학 내과학교실) ;
  • 홍석 (동신대학교 한의과대학 내과학교실)
  • Published : 2008.10.25
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Abstract

This experiment was performed to investigate the effects of Hyeonsamdansameum(HDE) on hypertension. For the study of HDE, we had divided Sprague-Dawley rats to three groups-normal, control, HDE. The control group was injected subcutaneous with monocrotaline(50 mg/kg). The treatment group was injected subcutaneous with monocrotaline(50 mg/kg) and orally administered with HDE extract for 4 weeks(once a day, 208 mg/kg). Then we measured blood pressure, heart rate, on the plasma aldosterone, catecholamine, electrolyte, uric acid, BUN, creatinine, and observed the lung, cardiac muscle. liver. etc. The results of these were as follows: 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity and superoxide dismutase(SOD) - like activity were increased. reactive oxygen species (ROS) was decreased. Angiotensin converting enzyme(ACE) inhibitory activity was increased in a concentration-dependent by HDE. HDE significantly increased body weight in monocrotaline hypertensive rat, so supported nearly normal group. HDE significantly decreased blood pressure and heart rate in monocrotaline hypertensive rat. HOE significantly decreased aldosterone in adrenocortical hormones. HDE significantly decreased dopamine. norepinephrine, epinephrine. Na+. Cl- were intended to decrease. K+ was decreased significantly by HDE. Uric acid. BUN were significantly decreased and creatinine was intended to decrease by HDE. HDE inhibited lung, liver and heart injury connected with hypertension. These results suggest that HDE is usefully applied in treatment and prevention of hypertension.

Keywords

References

  1. 통계청 인구동향과. 2006 사망원인 통계 결과. 대전, 통계청, p 3, 2007
  2. 이해경, 손길환. 한일 노인의 기대여명 차이에 영향을 미치는 사인에 대한 연구. 한국노년학회지 25(1):133-147, 2005
  3. 의학 교육연수원. 가정 의학. 서울, 서울대학교 출판부, pp 294-319, 343-348, 1996
  4. 오병희. 고혈압 치료의 최근 동향. 녹십자의보, 10(1):1-2, 2004
  5. 張元昌 外. 實用中醫內科學(下). 北京, 科學技術文獻出版社, p 1530, 1981
  6. 屈松栢 外. 實用中醫心血管病學. 北京, 科學技術文獻出版社, pp 301-304, 347-354, 1993
  7. 배경일, 김동희, 이용구, 김윤식, 설인찬. 疎風補心湯이 高血壓, 血栓 및 腦損傷에 미치는 영향. 동의병리학회지 16(2): 245-256, 2002
  8. 손은진, 강대길, 이안숙, 김복해, 이호섭. 黃連解毒湯 合 六味地黃湯 加 釣鉤藤이 자발적 고혈압 白鼠의 혈압 및 腎臟 기능에 미치는 영향. 동의병리학회지 16(2):359-364, 2002
  9. 김종원, 조현경, 유호룡, 설인찬, 김윤식. 고콜레스테롤 식이 자발성 고혈압 백서에서의 가미방풍통성산이 고혈압에 미치는 영향. 대한한방내과학회지 27(3):619-630, 2006
  10. 전연이, 박창국, 박치상, 이소연, 윤현덕, 신오철. 분심기음이 고혈압 백서와 인간유래 혈관 내피 세포주(ECV 304)에 미치는 영향에 대한 연구. 대한한방내과학회지 26(1):182-198, 2005
  11. 김종인, 김동희, 설인찬. 地黃飮子가 腦損傷 및 高血壓에 미치는 影響. 동의병리학회지 15(2):246-254, 2001
  12. 梁勇才 主編. 高血壓病(防治實效方). 北京, 化學工業文獻出版社, p 129, 2003
  13. Cushman, D.W., Cheung, H.S., Sabo, E.F., Ondetti, M.A. Development and design of specific inhibitors of angiotensin-converting enzyme. Am J Cardiol. 21, 49(6): 1390-1394, 1982
  14. 전국한의과대학 심계내과학교실. 심계내과학. 서울, 군자출판사, pp 154-159, 2006
  15. 이영우 외. 고혈압. 서울, 고려의학, pp 11-33, 112-115, 167-195, 2000
  16. Chobanian, A., Bakris, G., Black, H. et al. and National High Blood Pressure Education program Coordinating Committee. Seventh Report of the Joint National Commiitte on Prevention, Detection, Evaluation and Treatment of High Blood Pressure. JAMA. 289: 2560-2572, 2003 https://doi.org/10.1001/jama.289.19.2560
  17. 강은석, 강성귀. 신장과 본태성 고혈압 - 저 renin 성 고혈압. 대한내과학회지 65(4):389-394, 2003
  18. 신속태, 최일생 역. Pathophysiology로 이해하는 내과학 part 9. 서울, 정담출판사, p 85, 86, 2002
  19. Masato Furuhashi, Nobuyuki Ura, Katsuhiro Higashiura, Hideyuki Murakami, Marenao Tanaka, Norihito Moniwa, Daisuke Yoshida, Kazuaki Shimamoto. Blockade of the Renin-Angiotensin System Increases Adiponectin Concentrations in Patients With Essential Hypertension. Hypertension. 42: 76-81, 2003 https://doi.org/10.1161/01.HYP.0000078490.59735.6E
  20. Gorzelniak Kerstin, Engeli Stefan, Janke Jurgen, Luft Friedrich, C. Sharma, Arya, M. Hormonal regulation of the human adipose-tissue renin-angiotensin system: relationship to obesity and hypertension. Journal of Hypertension. 20(5):965-973, 2002 https://doi.org/10.1097/00004872-200205000-00032
  21. 김기훈, 문재우. 공중보건학. 서울, 정문각, pp 337-347, 1999
  22. 대한내과학회 해리슨 내과학 편집위원회 편. HARRISON'S 내과학. 서울, 도서출판 MIP, pp 276-284, 441-454, 1418-1428, 2003
  23. 전국의과대학교수 역. 오늘의 진단과 치료. 서울 한우리, pp 820-835, 2000
  24. 김지웅, 김영균, 권정남, 박지은. 고혈압의 원인에 관한 문헌적 고찰. 대한한방내과학회지 21(5):739-747, 2000
  25. 上海中醫學院 編. 中醫內科學. 香蒲, 商務印書館, pp 297-308, 1981
  26. 전국한의과대학 본초학교실. 본초학. 서울, 영림사, pp 172-173, 198, 199, 219, 237, 238, 244, 250, 298, 299, 372, 373, 469, 556, 558, 563, 564, 584, 585, 656, 658, 659, 1999
  27. Bryan, L., Copple Amy, Banes Patricia, E. Ganey, Robert, A. Roth. Endothelial Cell Injury and Fibrin Deposition in Rat Liver after Monocrotaline Exposure. Toxicological Sciences, 65: 309-318, 2002 https://doi.org/10.1093/toxsci/65.2.309
  28. Schultze, A.E., Roth, R.A. Chronic pulmonary hypertension the monocrotaline model and involvement of the hemostatic system. Journal of Toxicol environment Health Review. 1(4):271-346, 1998 https://doi.org/10.1080/10937409809524557
  29. Meyrick, B.W., Gamble, L. Development of Crotalaria pulmonary hypertention: hemodynamic and structural study. Journal of Physiology - Heart and Circulatory Physiology. 239(5):692-702, 1980 https://doi.org/10.1152/ajpheart.1980.239.5.H692
  30. Wilson, D.W., Segall, H.J., Pan, L.C., Lame, M.W., Estep, J.E., Morin, D. Mechanisms and pathology of monocrotaline pulmonary toxicity. Journal of Toxicol environment Health Review. 22(5-6):307-325, 1992
  31. 최기숙. 解毒正氣湯이 monocrotaline으로 유발된 흰쥐의 肝毒性에 미치는 影響. 동신대학교 대학원, 2007
  32. 김종원. 地栢地黃丸加味가 monocrotaline으로 유발된 흰쥐의 고혈압 병태모델에 미치는 영향. 대전대학교 대학원, 2008
  33. Gulam Waris, Haseeb Ahsan. Reactive oxygen species: role in the development of cancer and various chronic conditions. Journal of Carcinogenesis 5(14):1-8, 2006 https://doi.org/10.1186/1477-3163-5-1
  34. 대한병리학회. 병리학. 서울, 고문사, p 995, 1998
  35. 장호희, 김선영, 이상열. 산화스트레스에 의존한 식물 및 진핵세포 2-시스테인 퍼록시레독신의 기능 조절. 식물생명공학회지 33(1):1-9, 2006 https://doi.org/10.5010/JPB.2006.33.1.001
  36. Simon Melov, Joanne Ravenscroft, Sarwatt Malik, Matt, S., Gill David, W. Walker, Peter, E. Clayton Douglas, C. Wallace, Bernard Malfroy, Susan, R., Doctrow Gordon, J. Lithgow. Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics. 289(5484):1567-1569, 2000 https://doi.org/10.1126/science.289.5484.1567
  37. D.W. Morel, J.R. Hessler and G.M. Chisolm. Low density lipoprotein cytotoxicity induced by free radical peroxidation of lipid. J. Lipid Res., 24: 1070-1076, 1983
  38. David, S. Goodsell. Catalase. Molecule of the Month, 23: 4, 2004
  39. 대한내분비학회 편. 내분비학. 서울, 고려의학, pp 571-594, 1999
  40. Niels, A., Graudal Anders, M. Galle, Peter Garred. Effects of Sodium Restriction on Blood Pressure, Renin, Aldosterone, Catecholamines, Cholesterols, and Triglyceride: A Meta-analysis. JAMA, 279: 1383-1391, 1998 https://doi.org/10.1001/jama.279.17.1383
  41. 이귀녕, 권오헌. 임상병리파일. 서울, 의학문화사, pp 587-591, 609-612, 2000
  42. J.J. Duncan, J.E. Farr, S.J. Upton, R.D. Hagan, M.E. Oglesby, S.N. Blair. The effects of aerobic exercise on plasma catecholamines and blood pressure in patients withmild essential hypertension. JAMA, 254: 2609-2613, 1985 https://doi.org/10.1001/jama.254.18.2609
  43. P.K. Whelton, J. He, J.A. Cutler, F.L. Brancati, L.J. Appel, D. Follmann, M.J. Klag. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials. JAMA. 277(20):1624-1632, 1997 https://doi.org/10.1001/jama.277.20.1624
  44. Cappuccio, F.P., MacGregor, G.A. Does potassium supplementation lower blood pressure? A meta-analysis of published trials. Journal of Hypertension. 9(5):465-473, 1991 https://doi.org/10.1097/00004872-199105000-00011
  45. Stuart Ira Fox. 생리학. 서울, 라이프 사이언스, p 305, 405, 2004
  46. 대한임상의학연구소. 알기 쉬운 건강진단해설. 서울, 의학문화사, p 38, 39, 103, 104, 1994