Bulletin of the Korean Chemical Society

  • 제30권11호
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  • Pages.2574-2576
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  • 2009
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  • 0253-2964(pISSN)
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  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Electrochemical Detection of Glutathione on SAMs on Gold Using an Electroactive Quininoid-Type Molecule

  • Kim, So-Hyun (Department of Bioscience and Biotechnology, Konkuk University) ;
  • Kim, Jae-Il (Department of Bioscience and Biotechnology, Konkuk University) ;
  • Park, Hye-Ri (Department of Bioscience and Biotechnology, Konkuk University) ;
  • Kim, Mi-Kyoung (Department of Bioscience and Biotechnology, Konkuk University) ;
  • Chong, Yoo-Hoon (Department of Bioscience and Biotechnology, Konkuk University) ;
  • Yeo, Woon-Seok (Department of Bioscience and Biotechnology, Konkuk University)
  • 발행 : 2009.11.20
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초록

In this work, we describe a new sensor that specifically responds to biothiols, i.e., glutathione (GSH), in solution. An electrochemical transducing strategy was utilized and cyclic voltammetry (CV) was employed to monitor the presence of GSH in real time. Our approach harnessed self-assembled monolayers (SAMs) on gold consisting of an alkanethiolate which was terminated by electroactive quininoid moiety. Prior to thiol molecule treatment, the characterisitc reversible redox peaks of the electroactive quininoid group was observed, while the reduction peak was dramatically shifted upon a treatment of GSH. This sensor showed the capability to detect the GSH in solution in the range of 1 mM $\sim$ 100 aM. We believe that this strategy will provide an important tool for accurate, sensitive, rapid, and low-cost determination of GSH.

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참고문헌

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피인용 문헌

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  2. Selective Extraction and Quantification of Glutathione using Maleimide-Presenting Gold Nanoparticles vol.35, pp.10, 2014, https://doi.org/10.5012/bkcs.2014.35.10.3047
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  6. Selective Analysis of Thiol-Containing Molecules Using Nanoengineered Micro Gold Shells and LDI-TOF MS vol.33, pp.9, 2012, https://doi.org/10.5012/bkcs.2012.33.9.3076
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  8. A glutathione biosensor based on a glassy carbon electrode modified with CdO nanoparticle-decorated carbon nanotubes in a nafion matrix vol.183, pp.12, 2016, https://doi.org/10.1007/s00604-016-1987-0
  9. A reliable electrochemical approach for detection of testosterone with CuO-doped CeO2 nanocomposites-coated glassy carbon electrode vol.32, pp.4, 2009, https://doi.org/10.1007/s10854-021-05257-2
  10. Tetrahydrofuran Highly Enhances SAMDI Efficiency vol.42, pp.3, 2009, https://doi.org/10.1002/bkcs.12210