Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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A Study on Estimation of Carotid Intima-Media Thickness(IMT) using Pulse Wave Velocity(PWV)

맥파전달속도를 이용한 내중막 두께 추정에 관한 연구

  • Song, Sang-Ha (R&D Center, VIMED Systems co., LTD.) ;
  • Jang, Seung-Jin (Center for Brain & Cognitive Science Research, Division of Convergence Technology, Korea Research Institute of Standards and Science) ;
  • Kim, Wuon-Shik (Center for Brain & Cognitive Science Research, Division of Convergence Technology, Korea Research Institute of Standards and Science) ;
  • Lee, Hyun-Sook (Department of Oriental Biomedical Engineering, Sangji University) ;
  • Yoon, Young-Ro (Department of Biomedical Engineering, Yonsei University)
  • 송상하 (바이메드 시스템(주) 연구소) ;
  • 장승진 (한국표준과학연구원 미래융합기술부 뇌인지융합기술연구단) ;
  • 김원식 (한국표준과학연구원 미래융합기술부 뇌인지융합기술연구단) ;
  • 이현숙 (상지대학교 한방의료공학과) ;
  • 윤영로 (연세대학교 의공학부)
  • Published : 2009.10.31
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Abstract

In this paper, we correct pulse wave velocity(PWV) with heart-rate and derive regression equations to estimate intima-media thickness(IMT). Widely used methods for diagnosis of arteriosclerosis are IMT and PWV. Arterial wall stiffness determines the degree of energy absorbed by the elastic aorta and its recoil in diastole but there is not correlation between sclerosis and IMT in an existing study. In this study, we will correct PWV with heart-rate and get regression equation to estimate IMT using heart-rate correction index(HCI). We executed experiments for this study. Made up question of physical condition and measured electrocardiogram(ECG), photoplethysmogram (PPG) of finger-tip and toe-tip and ultrasound image of carotid artery. Calculated PWV and IMT using ECG, PPG and ultrasound image. We found that every p-value between PWV and IMT is not significant(<0.05). But p-value between IMT and HCI which is a corrected PWV using heart-rate is significant(>0.01). We use HCI and various measured parameter for estimating regression equation and apply backward estimation to select parameters for regression analysis. Result of backward estimation, found that only HCI is possible to derive proper regression equation of IMT. Relationship between PWV and IMT is the second order. Result of regression equation of E-H PWV is $R^2$=0.735, adj $R^2$=0.711. This is the best correlation value. We calculate error of its analysis for verification of earlobe PWV regression equation. Its result is RMSEP=0.0328, MAPE(%) = 4.7622. Like this regression analysis, we know that HCI is useful parameter and relationship between PWV, HCI and IMT. In addition, we are able to suggest possibility which is that we can get different parameter of prediction throughout just one measurement.

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References

  1. Geoffrey H. Tofler, James E. Muller , "Triggering of Acute Cardiovascular Disease and Potential Preventive Strategies.", Circulation., vol. 114, no. 17, pp.1863-1872, 2006 https://doi.org/10.1161/CIRCULATIONAHA.105.596189
  2. Sharrett AR, Sorlie PD, Chambless LE, Folsom AR, Hutchinson RG, Heiss G, Szklo M., "Relative importance of various risk factors for asymptomatic carotid atherosclerosis versus coronary heart disease incidence: the Atherosclerosis Risk in Communities Study", . Am J Epidemiol. vol.149, no.9, pp.843-852, 1999 https://doi.org/10.1093/oxfordjournals.aje.a009900
  3. Joo-Hee Zo, Lee Seon-Kyung, Kim Sang-Hyun, Kim Myung-A, "The Relationship of Pulse-wave Velocity with Carotid Intima-media Thickness and Carotid Artery Distensibility." J Cardiovasc Ultrasound., vol. 14, no. 3, 92-97, 2006
  4. Yambe Tomoyuki, Yoshizawa Makoto, Saijo Yoshifumi, Yamaguchi Tasuku, Shibata Muneichi, Konno Satoshi, Nitta Shinichi, Kuwayma Takashi, "Brachio-ankle pulse wave velocity and cardio-ankle vascular index (CAVI)", International Symposium Workshop on Circadian Rhythms and Clinical Chronotherapy, Tokyo , Japan, 2003, pp.S95-S98
  5. K.B. Chandran, D. Sc., Cardiovascular Biomechanics, United States of America, New York University Press., 1992. pp.138, 141, 185, 195
  6. Kim E. J., Park C. G., Park J. S., Suh S. Y., Choi C. U., Kim J. W., Kim S. H., Lim H. E., Rha S. W., Seo H. S., Oh D. J., "Relationship between blood pressure parameters and pulse wave velocity in normotensive and hypertensive subjects : Invasive study", J. Human Hypertension, vol. 21, no2, pp. 141-148, 2007 https://doi.org/10.1038/sj.jhh.1002120
  7. W.Chen, T.Kobayashi, S.Lehikawa, Y.Takeuchi, "Continuouse estimation of systolic blood pressure using the pulse arrival time and intermittent calibration", Med. Biol. Eng. Comput., vol. 38, no. 2, pp.569-574, 2000
  8. Michael O. Rourke, "Arterial Stiffness, Systolic Blood Pressure, and Logical Treatment of Artirial Hypertension", Hypertension, vol. 15, No. 4, pp.339-347, April 1990 https://doi.org/10.1161/01.HYP.15.4.339
  9. Wuon-Shik Kim, Hwna-Taek Jeong, Ki-Yong No, Jang-Ho Bae, "Measurements of Carotid Intima, Media, and Intima-media Thickness and Their Clinical Importance", Korean society of medical physics, vol. 16 No. 4, pp.207-213, 2005