Journal of Pharmacopuncture (대한약침학회지)

KOREAN PHARMACOPUNCTURE INSTITUTE (대한약침학회)
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The importance of clinical mistletoe cancer therapy and korean mistletoe pharmacopuncture preparation development and application possibility for oriental medicine

겨우살이 암치료제의 임상의학적 중요성과 한의학적 겨우살이 약침제제 개발 및 적용 가능성에 관한 고찰

  • Choi, Ok-Byung (Department of herbal medicine, Bio medicine Institute, Hoseo University)
  • 최옥병 (호서대학교 본초응용과학과 기초과학연구소)
  • Published : 2009.03.30
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Abstract

Objectives : Mistletoe extracts have been in use for around 85 years, predominantly in the area of cancer therapy. Today mistletoe preparations are among the most prescribed drugs in cancer medicine, thus constituting a standard biological therapy in the area of oncology. The purpose of this study is to analyze the practical implications of mistletoe cancer therapy, their clinical status, their preparation techniques and companies. Contents : Mistletoe therapy for cancer has been developed within the context of anthroposophical medicine. One major effect of mistletoe extract is that it stimulates the immune system and cancer defences. In Germany, a total of eight different mistletoe preparations are available, five developed by Anthroposophic Medicine and three evolved from research in phytotherapy. Therapy always consists of an introductory phase in order to test the patient's tolerance, find the right dosage and choose the most suitable preparation. This paper covers the background of mistletoe medical plant materials, mistletoe therapy for cancer, the anthroposophical medicine and clinical research, the practical regulation of treatment, preparation of mistletoe drugs. Result & suggestion : Mistletoe extracts are a complementary teratment of cancer, widely used in intergrative cancer care. The study of the integration of korean mistletoe extracts to oriental cancer medicine, its development and feasibility in Korea are urgently needed. The products, substances, compositions of european mistletoe drugs are very similar to those of oriental medicine theory. Applying the mistletoe cancer therapy and its preparation techniques to oriental medicine, the herbal acupuncture preparation should be modernized and korean mistletoe products are to be developed. To this end, government and herbal acupuncture society need to interact each other for the development of oriental mistletoe cancer medicine.

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References

  1. Goebel, T., Dorka, R.: Zur Morphologie und zur Zeitgestalt der Mistel (Viscum album L.). Tycho de Brahe-Verlag, Niefern 1986
  2. Aymon, P.: Mistletoe in advanced Cancer. The Cancer Journal 3. 1990; 123, Suppl. 3
  3. Reinsch, P.: Neues Jahrbuch fur Pharmazie, Band 14, J.C. Mohr, Heidelberg. 1860
  4. Obata, Y.J.: agric. Chem. Soc. Japan 17 . 1941; 110
  5. Einleger, I., Fischer, J., Zellner, J.: Mh. Chem. 1923 ; 44 : 277
  6. Leprince, M.: ibid. 1907 ; 145 : 940
  7. Khwaja, T.A., Dias, C.B., Pentecost, S.: Recent Studies on the anticancer activities of Mistletoe (Viscum album) and its alkaloids. Oncology. 1986 ; 43 : 42-50 https://doi.org/10.1159/000226419
  8. Havas, L.J.: Effects of colchicin and of Viscum album preparations upon germination of seeds and growth of seedlings. Nature (London). 1937 ; 139 : 371-372 https://doi.org/10.1038/139371a0
  9. Muller, E.A., Anderer, F.A.: Chemical specificity of effector cell/tumor cell bridging by a Viscum album rhamnogalactouran enhancing cytotoxicity of human NK cells. Immunpharmacology. 1990 ; 1 : 69-77 https://doi.org/10.1016/0162-3109(90)90028-D
  10. Samuelsson, G.: Mistletoe Toxins. System. Zoology. 1973 ; 22 : 566-569
  11. Obata, Y.J.: agric. Chem. Soc. Japan 1941 ; 17 : 219
  12. Franz, H.: Inhaltsstoffe der Mistel (Viscum album L.) als potentielle Arzneimittel. Pharmazie Suppl. 2. 1985 ; 40 : 97-104
  13. Selawry, O.S., Schwartz, M.R., Haar, H.: Tumor-inhibitory activity of products of Loranthaceae (mistletoe). Proc. amer. Assoc. Cancer Res. 1959 ; 3 : 62-63
  14. Winterfeld, K., Kronenthaler, A.: Zur Chemie des blutdrucksenkenden Bestandteils der Mistel (Viscum album). III. Mitteilung. Arch. Pharmaz. 1942 ; 280 : 103-115 https://doi.org/10.1002/ardp.19422800304
  15. Giudici, A. M., Regente, M. C., Villalain, J., Pf uller, K., Pf uller, U., de la Canal, L.Mistletoe viscotoxins induce membrane permeabilization and spore death in phytopathogenic fungi. Physiol. Plant., 2004 : 121 : 2-7 https://doi.org/10.1111/j.0031-9317.2004.00259.x
  16. Tabiasco, J., Pont, F., Fournie, J. J., Vercellone, A. Mistletoe viscotoxins increase natural killer cell-mediated cytotoxicity. Eur. J. Biochem., 2002 ; 269: 2591-2600 https://doi.org/10.1046/j.1432-1033.2002.02932.x
  17. Andersson K.E., Johannsson M. Effect of viscotoxin on rabbit heart and aorta, and on frog skeletal muscle. Eur. J. Pharmacol. 1973 ; 23 : 223-231 https://doi.org/10.1016/0014-2999(73)90087-3
  18. Schaller G., Urech, K., Giannattasio, M. Cytotoxicity of different viscotoxins and extracts from the European subspecies of Viscum album L. Phytother. Res., 1996 ; 10: 473-477 https://doi.org/10.1002/(SICI)1099-1573(199609)10:6<473::AID-PTR879>3.0.CO;2-Q
  19. Thunberg, E.: Phoratoxin B, a toxic protein from the mistletoe Phoradendron tomentosum sp. macrophyllum. Acta Pharmac. suecica. 1983 ; 20 : 115-122
  20. Boie, D.: Arbeitsbericht Nr. Verein fur Leuka-mie-und Krebstherapie, Rosenfeld 1977 ; 12
  21. Franz, H., Ziska, P., Kindt, A.: Isolation and properties of three lectins from misteltoe (Viscum album L.). Biochemical Journal. 1981 ; 195 : 481-184 https://doi.org/10.1042/bj1950481
  22. Franz, H., Ziska, P., Kindt, A.: A simple method for the preparation of the two different chains of the mistletoe lectin I. Lectins-Biology, Biochemistry, Clinical Biochemistry 2. Walter de Gruyter & Co., Berlin - New York 1982
  23. Agapov, I. I., Tonevitsky, A. G., Moisenovich, M. M., Maluchenko, N. V., Weyhenmeyer, R., Kirpichnikov, M. P. Mistletoe lectin dissociates into catalytic and binding subunits before translocation across the membrane to the cytoplasm. FEBS Lett., 1999b : 452: 211-214 https://doi.org/10.1016/S0014-5793(99)00639-0
  24. Bantel, H., Engels, I., H., Voelter, W., Schulze-Osthoff, K., Wesselborg, S. Mistletoe lectin activates caspase-8/FLICE independently of death receptor signaling and en hances anticancer drug-induced apoptosis. Cancer Res., 1999;59: 2083-2090
  25. Kienle, G. S., Kiene, H. Die Mistel in der Onkologie - Fakten und konzeptionelle Grundlagen. Schattauer Verlag, Stuttgart, New York. 2003
  26. Muller, J.A.: Arch. Pharmaz. 1932 ; 270 : 449 https://doi.org/10.1002/ardp.19322700805
  27. Samuelsson, G.: Phytochemical and Pharmacological Studies on Viscum album L. - III. Isolation of a hypotensive substance: Gammaaminobutyric acid. Svensk. farmac. Tidskr. 1959 ; 63 : 545-553
  28. Chernov, W.A.: Trud. Akad. med. Nauk SSSR, Vopr. onkol. 1954 ; 7
  29. Buhl, S.A.: Zur Wirkung von Iscador$^{(R)}$ und eines aus diesem gezuchteten Bakterienstammes auf einen Mausetumor und den tumortragenden Organismus. Dissertation, Heidelberg. 1961
  30. Zschiesche, W.: Die Wirkung von Iscador$^{(R)}$ auf Phagocytoseaktivitat des reticulohistiocytaren Systems. Mber. dtsch. Akad. Wiss. 1966 ; 8 : 750-754
  31. Bloksma, N., van Dijk, H., Korst, P., Willers, M.: Cellular and humoral adjuvant activity of a mistletoe extract. Immunobiol. 1979 ; 156 : 309-319
  32. Rentea, R., Lyon, E., Hunter, R.: Biologic Properties of Iscador$^{(R)}$: A Viscum album Preparation. I. Hyperplasia of the Thymic Cortex and Accelerated Regeneration of Hematopoietic Cells following X-Irradiation. Lab. Invest. 1981 ; 44 : 43-48
  33. Khwaja, T.A:, Varven, J.C., Pentecost, S., Pande, H.: Isolation of bilogically active alcaloids from Korean mistletoe viscum album, coloratum. Experentia (Basel).1980 ; 36 : 599-600 https://doi.org/10.1007/BF01965825
  34. Hulsen, H., Mechelke, F.: The influence of a mistletoe preparation on suspension cell cultures of human leukemia and human myeloma cells. Arzneimittelforschung. 1988 ; 32 : 172-179
  35. Vester, F., Bohne, L., El - Fouly, M.: Zur Kenntnis der Inhaltsstoffe von Viscum album. IV: Biologisches Verhalten einzelner Proteinfraktionen. Hoppe-Seyler's Z. Physiol. Chem. 1968 ; 349 : 495-511 https://doi.org/10.1515/bchm2.1968.349.1.495
  36. Stirpe, F., Legg, R.F., Onyon, L.J., Ziska, P., Franz, H.: Inhibition of protein synthesis by a toxic lectin from Viscum album L. (mistletoe). Biochem. J. 1980 ; 190 : 843-845 https://doi.org/10.1042/bj1900843
  37. Franz, H., Haustein, B., Luther, P., Kuropka, U., Kindt, A.: Isolierung und Charakterisierung von Inhaltsstoffen der Mistel. Acta biol. med. german. 1977 ; 36 : 113-117
  38. Koch, Fr.E.: Experimentelle Untersuchungen ber entz ndungs- und nekroseerzeugende Wirkung von Viscum album. Zeitschr. Ges. exper. Medizin 1938 ; 103 : 740-749 https://doi.org/10.1007/BF02627911
  39. Stumpf, C. und Schietzel, M.: Intrapleurale Instillation eines Mistelextraktes aus Viscum album (L.) zur Behandlung maligner Pleuraerg sse. Tumordiagn. u. Ther. 1994 ; 15 : 57-62
  40. Kiene, H.: Klinische Studien zur Misteltherapie karzinomat ser Erkrankungen - Eine bersicht. Sonderdruck aus: Therapeutikon. 1989 ; 3 : 347-353

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