Cardiovascular Risk according to the Components of Metabolic Syndrome in Type 2 Diabetes

제2형 당뇨병환자에서 대사증후군의 정도에 따른 심혈관질환 위험도

Lim, Dong-Mee;Park, Keun-Young;Kim, Byung-Joon;Lee, Kang-Woo;Lee, Myung-Jun;Yom, Yoon-Shick;Koh, Gwan-Pyo
임동미;박근용;김병준;이강우;이명준;염윤식;고관표

  • Published : 20090900

Abstract

The metabolic syndrome (MetS) is a constellation of interrelated risk factors to promote the development of atherosclerotic cardiovascular disease (CVD). In type 2 diabetes mellitus (T2DM), however, it has not yet been clarified whether the identification of the MetS improves the prediction of cardiovascular (CV) events. Framingham risk score (FRS) is an established predicting model for CVD. In the present study, we compared the impact of MetS with FRS on CV predictors in patients with T2DM. Seventy eight patients with T2DM (29 males and 49 females) were enrolled. Patients with history of CVD, any inflammatory disease and anti-hyperlipidemic medication were excluded. MetS was defined by modified NCEP-ATP III criteria. High-sensitivity C-reactive protein (hsCRP), homocysteine, lipoprotein(a), fibrinogen, uric acid and $\gamma$-glutamy transferase were regarded as CV predictors. 71.8% of total patients had the MetS. Diabetic patients with or without MetS were well matched in terms of the levels of all CV predictors. The CV factors were also not significantly different between numbers (1, 2, 3, 4 and 5) of components of the MetS. However, homocysteine (r = 0.317; P < 0.05), fibrinogen (r = 0.332; P <0.05) and uric acid (r = 0.268; P <0.05) levels were positively correlated with FRS. The levels of homocysteine (6.6 ${\pm}$ 1.7, 11.0 ${\pm}$ 3.7, 10.2 ${\pm}$ 3.7, 14.0 ${\pm}$ 6.1 and 11.3 ${\pm}$ 2.9 mmol/L; P < 0.001) and uric acid (3.2 ${\pm}$ 0.5, 4.6 ${\pm}$ 1.5, 5.4 ${\pm}$ 2.3, 7.1 ${\pm}$ 3.9 and 5.2 ${\pm}$ 2.2 mg/dL; P < 0.05) were significantly different to increasing quintiles of FRS. It suggests that categorizing type 2 diabetic subjects as having or not having the MetS does not provide further prediction of CVD. Collectively, these results suggest that the prediction of CVD was not related to the possession of the MetS in categorizing type 2 diabetic patients.

연구배경: 대사증후군은 한 개인에서 죽상동맥경화성 심혈관질환 위험인자들이 무리지어 발생하는 현상을 말한다. 그러나 제2형 당뇨병환자에서도 대사증후군이 관상동맥질환의 발생위험을 증가시키는지 확실치 않다. FRS는 관상동맥질환의 10년 위험도를 계산하는 전통적인 방법이다. 저자는 제2형 당뇨병에서 대사증후군 및 FRS와 관상동맥질환 예측인자들의 연관성을 분석하여 대사증후군이 관상동맥질환 위험도를 증가시키는지 간접적으로 알아보고자 하였다. 대상 및 방법: 제2형 당뇨병으로 진단 받은 78명을 대상으로 하였고(남자: 29명, 여자: 49명) 심혈관질환의 과거력, 고지혈증 약제의 복용력, 감염이 있는 환자는 제외하였다. 복부둘레는 남자 90 cm, 여자 85 cm을 적용하였고 나머지는 NCEP 기준에 따라 대사증후군을 진단하였다. 관상동맥질환의 예측인자로서는 hsCRP, 호모시스테인, 피브리노겐, 지단백(a), 요산, 감마지티를 측정하였다. 결과 및 결론: 전체 대상의 71.8%는 대사증후군을 가지고 있었다. 모든 관상동맥질환 예측인자들의 수치는 대사증후군을 가진 군과 없는 군 사이에 차이가 없었다. 대사증후군 각 진단인자 수에 따라 5개 군으로 나누어 비교하여도 차이가 없었다. 그러나 예측인자 중 호모시스테인(r = 0.317; P < 0.05), 피브리노겐(r = 0.332; P < 0.05), 요산 (r = 0.268; P < 0.05)는 FRS수와 의미 있는 양의 상관관계를 보였다. FRS를 크기에 따라 5군으로 나누어 비교하였을 때도 호모시스테인(6.6 ${\pm}$ 1.7, 11.0 ${\pm}$ 3.7, 10.2 ${\pm}$ 3.7, 14.0 ${\pm}$ 6.1 and 11.3 ${\pm}$ 2.9 mmol/L; P < 0.001)과 요산(3.2 ${\pm}$ 0.5, 4.6 ${\pm}$ 1.5, 5.4 ${\pm}$ 2.3, 7.1 ${\pm}$ 3.9 and 5.2 ${\pm}$ 2.2 mg/dL; P < 0.05)는 유의한 차이를 보였다. 제2형 당뇨병환자에서 대사증후군은 어떤 관상동맥질환 예측인자와도 관련이 없었으나 FRS는 일부 예측인자들과 유의한 연관성이 있었다. 이는 제2형 당뇨병에서 대사증후군은 관상동맥질환의 발생과 상관관계가 없다는 가능성을 시사한다.

Keywords

References

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