Laboraroty Animal Research

Korean Association for Laboratory Animal Science (한국실험동물학회)
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Stamina-Enhancing Effects of Silk Amino Acid Preparations in Mice

Shin, Sun-Hee;Park, Dong-Sun;Yeon, Seong-Ho;Jeon, Jeong-Hee;Kim, Tae-Kyun;Joo, Seong-Soo;Lim, Woo-Taek;Lee, Jeong-Yong;Kim, Yun-Bae

  • Published : 20090000
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Abstract

Effects of silk amino acid preparations (SAA-1, SAA-2 and SAA-3) on stamina and male reproductive functions were investigated. Eight-week-old male ICR mice (30-33 g) were orally administered with the preparations (800 mg/kg) for 30 days in resting condition or during 30-min daily swimming exercise. The mice were subjected to a weight-loaded (5% of body weight) forced swimming on 14th and 28th days to determine maximum swimming time, and after 2-day recovery period, parameters related to stamina and reproductive functions were analyzed from blood, muscles and testes. Repeated swimming performance increased the maximum swimming time to some extent, and the 3 SAA preparations further enhanced the stamina, in spite of reduced body weight gain in SAA-1- and SAA-3-treated mice. SAA-1 and SAA-2 exhibited long-term stamina-enhancing effects, while SAA-3 exerted an early marked activity on day 14. Swimming exercise increased blood parameters of muscular damage, liver injury, energy depletion and nitrogen accumulation, which were substantially prevented by SAA preparations, especially SAA-1 and SAA-2. All the SAA preparations increased testes weight, and SAA-3 and SAA-2 increased testosterone concentration, leading to enhanced sperm counts in resting and exercised mice, respectively. Taken together, it is suggested that all 3 SAA preparations possess an energy-boosting effect, although they exhibited different activities on male reproductive function.

Keywords

References

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