Korean Journal of Anesthesiology

The Korean Society of Anesthesiologists (대한마취통증의학회)
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Thermoregulatory responses of sevoflurane, desflurane, and isoflurane during gynecologic laparoscopic surgery

부인과 복강경 수술 시 Sevoflurane, Desflurane 그리고 Isoflurane의 체온조절반응

Jung, Jong-Dal;An, Tae-Hun;Song, Ho-Seok
정종달;안태훈;송호석

  • Published : 20090500
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Abstract

Background: Core temperature decreases rapidly after the induction of general anesthesia, because the heat is redistributed to peripheral tissues. Thermoregulatory responses of volatile anesthetics have been tested, but their effects have not been directly compared. Therefore, we evaluated the thermoregulatory responses to sevoflurane, desflurane, and isoflurane. Methods: Sixty healthy patients scheduled for laparoscopic myomectomy or radical hysterectomy were were allocated into three groups; Group S (sevoflurane, n = 20), Group D (desflurane, n = 20), and Group I (isoflurane, n = 20). Anesthesia was maintained with 1 minimum alveolar concentration (MAC) of sevoflurane, desflurane, and isoflurane in a 50/50 mixture of $N_2O$/$O_2$. Patients were maintained in a normovolemic and normocapnic state. The core temperature and forearm minus fingertip skin-temperature gradient (an index of peripheral vasoconstriction) were monitored after the induction of general anesthesia. Results: Each of the seven patients given sevoflurane, desflurane, and isoflurane vasoconstricted at a core temperature of 35.3 ${\pm}$ 0.5$^{\circ}C$, 33.6 ${\pm}$ 0.4$^{\circ}C$, and 35.2 ${\pm}$ 0.4$^{\circ}C$, respectively. The vas$^{\circ}C$onstriction threshold was the lowest in patients anesthetized with desflurane. The core temperature gradient (Ti−Tf) was significantly higher in patients that were anesthetized with desflurane than in those that were anesthetized with sevoflurane or isoflurane. The core temperature of desflurane was significantly lower than that of sevoflurane or isoflurane 15 minutes after the induction of anesthesia until 180 minutes of anesthesia. Conclusions: These results indicate that the core temperature is maintained at a higher level in patients that have been anesthetized with sevoflurane or isoflurane than in those that have been anesthetized with desflurane.

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References

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