Korean Journal of Otorhinolaryngology-Head and Neck Surgery

Korean Society of Otolaryngology-Head and Neck Surgery (대한이비인후과학회)
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Clinical Investigations in Patients with Taste Disorder

미각 장애 환자의 임상적 고찰

Lim, Geun-Hye;Shin, Seung-Heon;Ye, Mi-Kyung
임근혜;신승헌;예미경

  • Published : 20090500
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Abstract

Background and Objectives : Taste disorders have not received sufficient attention by otolaryngologists and only a few studies have documented the clinical characteristics of taste disorders. We therefore analyzed the characteristics of patients with taste disorders who visited our Taste and Smell Clinic over a 3-year period. Subjects and Method : Sixty patients with taste disorders were investigated. The efficacy of treatment was evaluated according to the age, sex, duration of symptom, cause, and severity of taste disorder. Results : Sixty percent of patients visited the clinic within 6 months of the onset of decrease in taste sensation. Multiple etiology was more common than single etiology. Taste disorder due to olfactory disorder was the most frequent etiology, followed by drug induced taste disorder and taste disorder due to zinc deficiency. Sixty percent of the patients experienced improvement of the taste abnormality. The efficacy of treatment decreased with increasing severity of taste disorder at the initial visit. Conclusion : Careful history taking and physical examination are needed for determination of the cause of any taste abnormality. The site and severity of dysgeusia should be determined through the chemical and electrical taste threshold test. Treatment should direct toward the causative abnormality, if possible.

Keywords

References

  1. Leopold DA, Bartoshuk L, Doty RL, Jafek B, Smith DV, Snow JB. Aging of the upper airway and the senses of taste and smell. Otolaryngol Head Neck Surg 1989;100(4):287-9
  2. Ye MK. Diagnosis and treatment of taste disorder. J Clinical Otolaryngol 2007;18:28-32
  3. Hamada N, Endo S, Tomita H. Characteristics of 2278 patients visiting the Nihon University Hospital Taste Clinic over a 10-year period with special reference to age and sex distributions. Acta Otolaryngol Suppl 2002;122(546):7-15
  4. Tomita H, Ikeda M. Clinical use of electrogustometry: strengths and limitations. Acta Otolaryngol 2002;122 Suppl 546:27-38 https://doi.org/10.1080/00016480260046391
  5. Kim SH, Jang SY, Choi JK. Taste preference and whole-mouth taste threshold in a Korean population in the age of the 3rd decade. Korean J Oral Med 2003;28(4):413-26
  6. Osaki T, Ohshima M, Tomita Y, Matsugi N, Nomura Y. Clinical and physiological investigations in patients with taste abnormality. J Oral Pathol Med 1996;25(1):38-43 https://doi.org/10.1111/j.1600-0714.1996.tb01221.x
  7. Bartoshuk L. Clinical evaluation of the sense of taste. Ear Nose Throat J 1989;68(4):331-7
  8. Brightman VJ. Abnormalities of taste. In Lynch MA, Brightman VJ, Greenberg MS, editors. Burket's oral medicine diagnosis and treatment. 9th ed. J.B.Lippincott Co.;1994. p.343-68
  9. Doty RL, Bartoshuk LM, Snow JB Jr. Causes of olfactory and gustatory disorders. In Getchell TV, Doty RL, Bartoshuk LM, Snow JB, Jr, editors. Smell and taste in health and disease. New York; Raven press;1991. p.449-62
  10. Deems DA, Doty RL, Settle RG, Moore-Gillon V, Shaman P, Mester AF, et al. Smell and taste disorders, a study of 750 patients from the University of Pennsylvania Smell and Taste Center. Arch Otolaryngol Head Neck Surg 1991;117(5):519-28 https://doi.org/10.1001/archotol.1991.01870170065015
  11. Tanaka M, Kitago H, Ogawa S, Tokunaga E, Ikeda M, Tomita H. Incidence and treatment of dysgeusia in patients with glossodynia. Acta Otolaryngol 2002;122 Suppl 546:142-5 https://doi.org/10.1080/00016480260046535
  12. Tanaka M. Secretory function of the salivary gland in patients with taste disorders or xerostomia: Correlation with zinc deficiency. Acta Otolaryngol 2002;122 Suppl 546:134-41 https://doi.org/10.1080/00016480260046526
  13. Fox PC, van der Ven PF, Baum BJ, Mandel ID. Pilocarpine for the treatment of xerostomia associated with salivary gland dysfunction. Oral Surg Oral Med Oral Pathol 1986;61(3):243-8 https://doi.org/10.1016/0030-4220(86)90369-5
  14. Sakai F, Yoshida S, Endo S, Tomita H. Double-blind, placebo-controlled trial of zinc picolinate for taste disorders. Acta Otolaryngol Suppl 2002;122(546):129-33
  15. Sakai F, Yoshida S, Endo S, Tomita H. Therapeutic efficacy of zinc picolinate in patients with taste disorders. Nippon Jibiinkoka Gakkai Kaiho 1995;98(7):1135-9 https://doi.org/10.3950/jibiinkoka.98.1135

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