Journal of Korean Society of Occupational and Environmental Hygiene (한국산업보건학회지)

Korean Industrial Hygiene Association (한국산업보건학회)
권호 표지

Changes of physiological levels of the risk factors contributing to induction of metabolic syndrome in workers chronically exposed to styrene

만성적인 스티렌 노출 근로자에 있어 대사증후군 유발에 관여하는 위험요인의 생리적 수준 변화

  • Heo, Kyung-Hwa (Occupational Safety and Health Research Institute, KOSHA) ;
  • Koo, Jung-Wan (Callege of Medicine, Catholic University) ;
  • Won, Yong Lim (Occupational Safety and Health Research Institute, KOSHA) ;
  • Kim, Min Gi (Occupational Safety and Health Research Institute, KOSHA) ;
  • Ko, Kyung Sun (Occupational Safety and Health Research Institute, KOSHA) ;
  • Lee, Mi-Young (Occupational Safety and Health Research Institute, KOSHA) ;
  • Kim, Tae Kyun (Occupational Safety and Health Research Institute, KOSHA) ;
  • Kim, Ki-Woong (Occupational Safety and Health Research Institute, KOSHA)
  • 허경화 (한국산업안전보건공단 산업안전보건연구원) ;
  • 구정완 (가톨릭대학교 의과대학) ;
  • 원용림 (한국산업안전보건공단 산업안전보건연구원) ;
  • 김민기 (한국산업안전보건공단 산업안전보건연구원) ;
  • 고경선 (한국산업안전보건공단 산업안전보건연구원) ;
  • 이미영 (한국산업안전보건공단 산업안전보건연구원) ;
  • 김태균 (한국산업안전보건공단 산업안전보건연구원) ;
  • 김기웅 (한국산업안전보건공단 산업안전보건연구원)
  • Received : 2008.08.07
  • Accepted : 2009.03.09
  • Published : 2009.03.31
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Abstract

The objective of this study was to evaluate the effects of occupational exposure to styrene on the components of metabolic syndrome. We surveyed 263 employees, among whom 117workers we ere chronically exposed to styrene in glass-reinforced plastic boat manufacturing factories and 146 controls had never been occupationally exposed to styrene as will as hazardous chemicals. The general and job characteristics such as age, smoking and drinking habit, working hours and duration were not significant different except sleeping hours(p<0.05). Among the components of metabolic syndrome, the systolic blood pressure, total cholesterol, HDL-cholesterol and fasting glucose were significantly higher in exposed workers. On multiple logistic regression analysis for the components of metabolic syndrome, waist circumference was insulin (OR=1.129), blood pressure was MA(OR=14.724), fasting glucose(OR=1.191) and metabolic syndrome(OR=1.110) were significantly associated with insulin. The mean concentration of airborne styrene was $ 38.1{\pm}40.1$ ppm, blood concentrations of glucose and insulin and levels of HOMA-IR in over 50 ppm exposed group were higher than in blow 50 ppm exposed group. These results suggested that the exposure of styrene affects blood pressure, fasting glucose and insulin levels and that dysfunction and/or declination in glucose and insulin metabolism might induced ultimately insulin resistance and metabolic syndrome.

Keywords

References

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