Annals of Surgical Treatment and Research

The Korean Surgical Society (대한외과학회)
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Prognostic Factors Influence on the Systemic Recurrence in Axillary Lymph Node Negative Breast Cancer

액와 림프절 전이가 없는 유방암에서 전신 재발에 영향을 미치는 인자들

Lee, Hee-Seung;Kwak, Beom-Seok;Son, Byung-Ho;Ahn, Sei-Hyun
이희승;곽범석;손병호;안세현

  • Published : 20091000
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Abstract

Purpose: Axillary lymph node metastasis is one of the most important prognostic factors in breast cancer. Previous reports show differences that clinicopathologic factors influence the systemic recurrence and survival in axillary lymph node negative breast cancer. Thus, we have attempted to determine the prognostic factors influence on the systemic recurrence and survival in axillary lymph node negative breast cancer. Methods: We retrospectively reviewed the data of 1,351 node negative breast cancer patients who underwent curative surgery to determine the prognostic factors such as age, sex, body mass index (BMI), family history, bilateral breast cancer, operation method, tumor size, stage, histologic grade, number of resected lymph nodes, hormone receptor status, overexpression of p53 and c-erbB2, and adjuvant therapy that influence the systemic recurrence and 10-year-distant relapse-free survival. Results: Systemic recurrence occurred in 58 patients (4.3%) during 53.3 months median follow up period. The tumor size (P=0.001), stage (P=0.005), histologic grade (P=0.049). ER (P=0.028), PR (P=0.002), overexpression of p53 (P=0.001) and bilateral breast cancer (P=0.043) were statistically significant factors that influenced the systemic recurrence. In multivariate analysis, only tumor size was associated with the systemic recurrence (P=0.003). Tumor size (P=0.004), histologic grade (P=0.035), ER (P=0.046), PR (P=0.001) and bilateral cancer (P=0.003) were statistically significant factors that influenced 10-year-distant relapse-free survival. Conclusion: The larger tumor size was determined to be an independent prognostic value in axillary lymph node negative breast cancer.

Keywords

References

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