Korean journal of dermatology (대한피부과학회지)

Korean Dermatological Association (대한피부과학회)
권호 표지

Standard Patch Test Results in Patients with Contact Dermatitis

접촉피부염 환자에서 최근 5년간 표준항원 첩포시험 성적

Bae, You-In;Han, Jung-Hyun;Yun, Sook-Jung;Lee, Jee-Bum;Kim, Seong-Jin;Lee, Seung-Chul;Won, Young-Ho
배유인;한정현;윤숙정;이지범;김성진;이승철;원영호

  • Published : 20091100
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Abstract

Background: A number of skin manifestations in patients with allergic contact dermatitis result from sensitization with specific allergens. The patch test is a primary diagnostic tool for identifying allergens causing allergic contact dermatitis. Objective: We identified the results of patch test with Korean standard series in patients with clinically diagnosed with contact dermatitis, and evaluated the specific relationship with each allergen. Methods: During a 5-year period, 743 patients were examined with patch test of standard Korean series. The results of patch test were then evaluated. Location of the skin lesion, age, sex, and occupation of the patients were completely reviewed. Results: Overall, 68.5% of patients had at least one positive reaction and 43.6% of patients had two or more positive reactions. Allergens most frequently causing positive reactions were nickel sulfate (27.1%), cobalt chloride (22.1%), potassium dichromate (17.9%), mercuric ammonium chloride (13.8%), and 4-phenyledediamine base (10.2%). Those patients in their 10s and 40s showed the highest rate of positive reaction. Metal allergens displayed higher positive rates than any other standard allergens. Of 201 patients who showed positive reaction to nickel, 37.8% and 27.3% of them also showed positive reaction to cobalt and chromium, respectively, representing concomitant reactions between metal-related antigens. In addition, polysensitization to cosmetics-related antigens including balsam peru and fragnance mix was evident. Conclusion: There was no significant difference in overall positive rate in patch test results compared with recent studies. However, we confirmed that metal-related allergens remain most common, and that multiple contact allergy were relatively common.

Keywords

References

  1. Adams RM, Fisher AA. Contact allergen alternatives. J Am Acad Dermatol 1986;14:951-963 https://doi.org/10.1016/S0190-9622(86)70119-9
  2. Woo TH, Kook HI, Cho KU, Park YK, Clinical observation on the allergic contact dermatitis in Korea. Korean J Dermatol 1972;10:77-83
  3. Lee KW, Kim CW. A study on delayed reaction to standard allergens in contact dermatitis. J Catholic Med College 1984;37:883-891
  4. Eun HC, Koh CJ, Kook HI, Kim DH, Kim CW, Kim HJ, et al. An epidemiological study of contact dermatitis. Korean J Dermatol 1986;24:335-339
  5. Choi YS, Bang DS. Result of patch test in Kangwon province. Korean J Dermatol 1990;28:519-526
  6. Moon KC, Eun HC, Kim HO, Kim KJ, Hong CG, Lee CH, et al. An epidemiological study of contact dermatitis in Korea (1986-1993). Korean J Dermatol 1995;33:445-452
  7. Park JH, Ro YS. Occupational skin disease in hairdressers: results of patch test. Korean J Dermatol 2006;44:669-674
  8. Belsito DV. Allergic contact dermatitis, In: Freedberg IM, Eisen AZ, Wolff K, Austen KF, Goldsmith LA, Katz SI, editors. Fitzpatrick's dermatology in general medicine. 6th ed. New York: McGraw-Hill, 2003:1164-1171
  9. Beissert S, Cavazzana I, Mascia F, Meroni P, Pastore S, Tessari G, et al. Mechanisms of immune-mediated skin diseases: an overview. Clin Exp Rheumatol 2006;24:S1-S6
  10. Saint-Mezard P, Rosieres A, Krasteva M, Berard F, Dubois B, Kaiserlian D, et al. Allergic contact dermatitis. Eur J Dermatol 2004;14:284-295
  11. Bruynzeel DP, Diepgen TL, Andersen KE, Brandao FM, Frosch PJ, Goosens A, et al. Monitoring the European standard series in 10 centers 1996-2000. Contact Dermatitis 2005;53:146-149 https://doi.org/10.1111/j.0105-1873.2005.00541.x
  12. Pratt MD, Belsito DV, DeLeo VA, Fowler JF, Fransway AF, Maibach HI, et al. North American Contact Dermatitis Group patch-test results, 2001-2002 study period. Dermatitis 2004;15:176-183 https://doi.org/10.2310/6620.2004.04038
  13. Wetter DA, Davis MD, Yiannias JA, Cheng JF, Connolly SM, el-Azhary RA, et al. Patch test results from the Mayo clinic contact dermatitis group, 1998-2000. J Am Acad Dermatol 2005;53:416-421 https://doi.org/10.1016/j.jaad.2005.04.077
  14. Lee GY, Kim JK, Kim KJ. A study of the results of patch test in patients with contact dermatitis. Korean J Dermatol 2007;45:908-914
  15. Kim BJ, Kwon HB, Lee JH, Lee SH, Lee AY. An epidemiologic study on patch test positivities for patients with allergic contact dermatitis. Korean J Dermatol 2008;46:1362-1368
  16. Purello D'Ambrosio F, Bagnato GF, Guarneri B, Musarra A. The role of nickel in foods excerbating nickel contact dermatitis. Allergy 1998;53:143-145 https://doi.org/10.1111/j.1398-9995.1998.tb04986.x
  17. Smart GA, Sherlock JC. Nickel in foods and the diet. Food Addi Contam 1987;4:61-71 https://doi.org/10.1080/02652038709373616
  18. Han HJ, Lee BH, Park CW, Lee CH, Kang YS. A study of nickel content in Korean foods. Korean J Dermatol 2005;43:593-598
  19. Ruff CA, Belsito DV. The impact of various patient factors on contact allergy to nickel, cobalt, and chromate. J Am Acad Dermatol 2006;55:32-39 https://doi.org/10.1016/j.jaad.2006.04.015
  20. Liden C, Wahlberg JE. Cross-reactivity to metal compounds studied in guinea pigs induced with chromate or cobalt. Acta Derm Venereol (Stockh) 1994;74:341-343
  21. Seidenari S, Mantovani L, Manzini BM, Pignatti M. Crosssensitizations between azo dyes and para-amino compound. A study of 236 azo-dye sensitive subjects. Contact Dermatitis 1997;36:91-96 https://doi.org/10.1111/j.1600-0536.1997.tb00420.x
  22. Seidenari S, Giusti F, Massone F, Mantovani L. Sensitization to disperse dyes in a patch test population over a five-year period. Am J Contact Dermat 2002;13:101-107 https://doi.org/10.1053/ajcd.2002.34570
  23. Girardin P, Vigan M, Humbert P, Aubin F. Cross-reactions in patch testing with ketoprofen, fragrance mix and cinnamic derivatives. Contact Dermatitis 2006;55:126-128
  24. Carlsen BC, Andersen KE, Menne T, Johansen JD. Patients with multiple contact allergies: a review. Contact Dermatitis 2008;58:1-8 https://doi.org/10.1111/j.1600-0536.2008.01378.x
  25. Park JK, Seong BJ, Kim YH, Lee JH. Epidemiologic study on contact sensitization of 206 healthy persons. Chungnam Med J 1991;18:329-334