DOI QR코드

DOI QR Code

A Case of Posterior Ischemic Optic Neuropathy and Abducens Nerve Palsy

외향신경마비를 동반한 비동맥염성 뒤허혈시신경병증 1예

Song, Tae-Geun;Park, Hye-Young
송태근;박혜영

  • Published : 2009.02.15

Abstract

Purpose: To report a case of a patient with posterior ischemic optic neuropathy and abducens nerve palsy who responded to steroid therapy. Case summary: A 47-year-old man visited our clinic with decreasing visual acuity and abduction limitation in his right eye, which suddenly started 4 days earlier. The best corrected visual acuity (BCVA) was 20/250 in the right eye and 20/20 in the left eye. Fundus examination showed normal in both eyes, and relative afferent pupillary defect was positive in the right eye. The visual field test showed a right central scotoma with inferior altitudinal field defect. In addition, the brain magnetic resonance imaging (MRI) was done. Orbit MRI, fluorescein angiography (FAG), and carotid ultrasonography results were normal. Therefore, the patient was diagnosed with non-arteritic posterior ischemic optic neuropathy. The systemic steroid therapy was started and tapered over a period of 5 weeks. At one month after treatment, the BCVA was 20/20 and abduction limitation in the right eye improved.

목적: 비동맥염성 뒤허혈시신경병증과 외향신경마비를 동반한 환자에서 스테로이드 치료로 시기능 향상 및 외향신경마비의 호전을 경험하였기에 이를 보고하고자 한다. 증례요약: 47세 남자 환자가 4일 전부터 발생한 우안 시력저하를 주소로 내원하였다. 최대교정시력은 우안) 20/250, 좌안) 20/20이었으며 우안의 구심성동공운동장애가 관찰되었다. 안저검사는 정상이었고, 눈 운동검사에서 우측 외향신경마비가 관찰되었다. 정확한 진단을 위하여 색각검사, 시야검사, 형광안저혈관조영술, 시각유발전위검사, 혈액검사, 뇌와 안와 자기공명영상, 경동맥초음파검사를 시행하였다. 우안의 심한 색각이상과 시야검사상 우안의 중심암점과 아래쪽의 시야결손이 관찰되었다. 시각유발전위검사에서 현저한 진폭의 감소가 관찰되었으며 혈액검사는 혈당과 콜레스테롤이 증가되어 있었고, 자기공명영상, 경동맥초음파, 형광안저혈관조영술은 정상이었다. 이에 비동맥염성 뒤허혈시신경병증으로 진단하고 스테로이드 정맥주사를 시행하였다. 치료 5일째 최대교정시력 20/20까지 회복되었고 외향신경마비도 호전되는 양상을 보였다. 1개월 후 시행한 검사에서 시력은 20/20으로 유지되었고, 안구운동장애는 관찰되지 않았다.

Keywords

References

  1. Jung JY, Kim JS. Comparison of optic disc appearance in anterior ischemic optic neuropathy and optic neuritis. J Korean Ophthalmol Soc 2003;44:157-61
  2. Kim DH, Hwang JM. Risk factors for Korean patients with anterior ischemic optic neuropathy. J Korean Ophthalmol Soc 2007;48:1527-31 https://doi.org/10.3341/jkos.2007.48.11.1527
  3. Park WC, Chang BL. Clinical features of anterior ischemic optic neuropathy. J Korean Ophthalmol Soc 2003;44:144-9
  4. Jun BK, Kim DS, Ko MK. Clinical features in anterior ischemic optic neuropathy. J Korean Ophthalmol Soc 1999;40:3460-7
  5. Hayreh SS. Posterior ischemic optic neuropathy : clinical features, pathogenesis, and management. Eye 2004;18:1188-206 https://doi.org/10.1038/sj.eye.6701562
  6. Hayreh SS. Ischemic optic neuropathy. Indian J Ophthalmol 2000;48:171-94
  7. Sadda SR, Nee M, Miller NR, et al. Clinical spectrum of posterior ischemic optic neuropathy. Am J Ophthalmol 2001;132:743-50 https://doi.org/10.1016/S0002-9394(01)01199-0
  8. Isayama Y, Takahashi T, Inoue M, et al. Posterior ischemic optic neuropathy III. Clinical Diagnosis. Ophthalmologica 1983;187:141-7 https://doi.org/10.1159/000309314
  9. Jeon C, Sa HS, Oh SY. Causes and natural course of the sixth cranial nerve palsy. J Korean Ophthalmol Soc 2006;47:1776-80
  10. Kim SS, Jin KH, Kim SM. Neuro-opthalmologic evaluation of the third, fourth, and sixth cranial nerve paralysis. J Korean Ophthalmol Soc 1991;32:283-8
  11. Park KH, Chang BL. The etiology and clinical feature of the third, fourth, and sixth cranial nerve palsy. J Korean Ophthalmol Soc 1997;38:1432-6
  12. Hayreh SS, Posterior ischemic optic neuropathy. Ophalmologica 1981;182:29-41 https://doi.org/10.1159/000309085
  13. Cullen JF, Por YM. Ischemic optic neuropathy : the Singapore scene. Singapore Med J 2007;48:281-6
  14. Smith KJ, Mcdonald WI. The pathophysiology of multiple sclerosis : the mechanisms underlying the production of symptoms and the natural history of the disease. Philos Trans R Soc Lond B Biol Sci 1999;354:1649-73 https://doi.org/10.1098/rstb.1999.0510
  15. Milea D, Napolitano M, Dechy H, et al. Complete bilateral horizontal gaze paralysis disclosing multiple sclerosis. J Neurol Neurosurg Psychiatry 2001;70:252-5 https://doi.org/10.1136/jnnp.70.2.252
  16. Tan E, Kansu T. Bilateral horizontal gaze palsy in multiple sclerosis. J Clin Neuroophthalmol 1990;10:124-6
  17. Lee AG. Reversible loss of vision due to posterior ischemic optic neuropathy. Can J Ophthalmol 1995;30:327-9
  18. Rucker CW. Paralysis of the third, fourth, and sixth cranial nerves. Am J Ophthalmol 1958;46:787-94
  19. Rucker CW. The causes of paralysis of the third, fourth, and sixth cranial nerves. Am J Ophthalmol 1966;61:1293-8
  20. Rush JA, Young BR. Paralysis of cranial nerves III, IV, and VI : Cause and prognosis in 1000 cases. Arch Ophthalmol 1981;99:76-80 https://doi.org/10.1001/archopht.1981.03930010078006
  21. Jacobson DM, McCanna TD, Layde PM. Risk factors for ischemic ocular motor nerve palsies. Arch Ophthalmol 1994;112:961-6 https://doi.org/10.1001/archopht.1994.01090190109029