Journal of Veterinary Science

The Korean Society of Veterinary Science (대한수의학회)
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Protection of chicken against very virulent IBDV provided by in ovo primingwith DNA vaccine and boosting with killed vaccine and the adjuvant effects of plasmid-encoded chicken interleukin-2 and interferon-$\gamma$

Park, Jeong-Ho;Sung, Haan-Woo;Yoon, Byung-Il;Kwon, Hyuk-Moo

  • Published : 20090600
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Abstract

The aim of this study was to examine the efficacy of in ovo prime-boost vaccination against infectious bursal disease virus (IBDV) using a DNA vaccine to prime in ovo followed by a killed-vaccine boost post hatching. In addition, the adjuvant effects of plasmid-encoded chicken interleukin-2 and chicken interferon-$\gamma$ were tested in conjunction with the vaccine. A plasmid DNA vaccine (pcDNA-VP243) encoding the VP2, VP4, and VP3 proteins of the very virulent IBDV (vvIBDV) SH/92 strain was injected into the amniotic sac alone or in combination with a plasmid encoding chicken IL-2 (ChIL-2) or chicken IFN-$\gamma$ (ChIFN-$\gamma$) at embryonation day 18, followed by an intramuscular injection of a commercial killed IBD vaccine at 1 week of age. The chickens were orally challenged with the vvIBDV SH/92 strain at 3 weeks of age and observed for 10 days. In ovo DNA immunization followed by a killedvaccine boost provided significantly better immunity than the other options. No mortality was observed in this group after a challenge with the vvIBDV. The prime-boost strategy was moderately effective against bursal damage, which was measured by the bursa weight/body weight ratio, the presence of IBDV RNA, and the bursal lesion score. In ovo DNA vaccination with no boost did not provide sufficient immunity, and the addition of ChIL-2 or ChIFN-$\gamma$ did not enhance protective immunity. In the ConA-induced lymphocyte proliferation assay of peripheral blood lymphocyte collected 10 days post-challenge, there was greater proliferation responses in the DNA vaccine plus boost and DNA vaccine with ChIL-2 plus boost groups compared to the other groups. These findings suggest that priming with DNA vaccine and boosting with killed vaccine is an effective strategy for protecting chickens against vvIBDV.

Keywords

References

  1. Asif M, Jenkins KA, Hilton LS, Kimpton WG, Bean AG, Lowenthal JW. Cytokines as adjuvants for avian vaccines. Immunol Cell Biol 2004, 82, 638-643 https://doi.org/10.1111/j.1440-1711.2004.01295.x
  2. Chang HC, Lin TL, Wu CC. DNA-mediated vaccination against infectious bursal disease in chickens. Vaccine 2001, 20, 328-335 https://doi.org/10.1016/S0264-410X(01)00376-0
  3. Chang HC, Lin TL, Wu CC. DNA vaccination with plasmids containing various fragments of large segment genome of infectious bursal disease virus. Vaccine 2003, 21, 507-513 https://doi.org/10.1016/S0264-410X(02)00473-5
  4. Coletti M, Del Rossi E, Franciosini MP, Passamonti F, Tacconi G, Marini C. Efficacy and safety of an infectious bursal disease virus intermediate vaccine in ovo. Avian Dis 2001, 45, 1036-1043 https://doi.org/10.2307/1592885
  5. Fahey KJ, Erny K, Crooks J. A conformational immunogen on VP-2 of infectious bursal disease virus that induces virus-neutralizing antibodies that passively protect chicken. J Gen Virol 1989, 70, 1473-1481 https://doi.org/10.1099/0022-1317-70-6-1473
  6. Francois A, Chevalier C, Delmas B, Eterradossi N, Toquin D, Rivallan G, Langlois P. Avian adenovirus CELO recombinants expressing VP2 of infectious bursal disease virus induce protection against bursal disease in chickens. Vaccine 2004, 22, 2351-2360 https://doi.org/10.1016/j.vaccine.2003.10.039
  7. Harms JS, Oliveira SC, Splitter GA. Regulation of transgene expression in genetic immunization. Braz J Med Biol Res 1999, 32, 155-162 https://doi.org/10.1590/S0100-879X1999000200003
  8. Haygreen EA, Kaiser P, Burgess SC, Davison TF. In ovo DNA immunisation followed by a recombinant fowlpox boost is fully protective to challenge with virulent IBDV. Vaccine 2006, 24, 4951-4961 https://doi.org/10.1016/j.vaccine.2006.03.060
  9. Hicks CR, Turner KV. Fundamental Concepts in the Design of Experiments. pp. 195-196. Oxford University Press, New York, 1996
  10. Hsieh MK, Wu CC, Lin TL. The effect of co-administration of DNA carrying chicken interferon-gamma gene on protection of chickens against infectious bursal disease by DNAmediated vaccination. Vaccine 2006, 24, 6955-6965 https://doi.org/10.1016/j.vaccine.2006.05.127
  11. Hsieh MK, Wu CC, Lin TL. Priming with DNA vaccine and boosting with killed vaccine conferring protection of chickens against infectious bursal disease. Vaccine 2007, 25, 5417-5427 https://doi.org/10.1016/j.vaccine.2007.04.087
  12. Hulse DJ, Romero CH. Partial protection against infectious bursal disease virus through DNA-mediated vaccination with the VP2 capsid protein and chicken IL-2 genes. Vaccine 2004, 22, 1249-1259 https://doi.org/10.1016/j.vaccine.2003.09.021
  13. Kapczynski DR, Hilt DA, Shapiro D, Sellers HS, Jackwood MW. Protection of chickens from infectious bronchitis by in ovo and intramuscular vaccination with a DNA vaccine expressing the S1 glycoprotein. Avian Dis 2003, 47, 272-285 https://doi.org/10.1637/0005-2086(2003)047[0272:POCFIB]2.0.CO;2
  14. Kibenge FSB, Dhillon AS, Russell RG. Biochemistry and immunology of infectious bursal disease virus. J Gen Virol 1988, 69, 1757-1775 https://doi.org/10.1099/0022-1317-69-8-1757
  15. Kim SJ, Sung HW, Han JH, Jackwood D, Kwon HM. Protection against very virulent infectious bursal disease virus in chickens immunized with DNA vaccines. Vet Microbiol 2004, 101, 39-51 https://doi.org/10.1016/j.vetmic.2004.03.009
  16. Kozak M. At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells. J Mol Biol 1987, 196, 947-950 https://doi.org/10.1016/0022-2836(87)90418-9
  17. Kumar S, Ahi YS, Salunkhe SS, Koul M, Tiwari AK, Gupta PK, Rai A. Effective protection by high efficiency bicistronic DNA vaccine against infectious bursal disease virus expressing VP2 protein and chicken IL-2. Vaccine 2009, 27, 864-869 https://doi.org/10.1016/j.vaccine.2008.11.085
  18. Larsen DL, Karasin A, Olsen CW. Immunization of pigs against influenza virus infection by DNA vaccine priming followed by killed-virus vaccine boosting. Vaccine 2001, 19, 2842-2853 https://doi.org/10.1016/S0264-410X(01)00014-7
  19. Li Y, Stirling CM, Denyer MS, Hamblin P, Hutchings G, Takamatsu HH, Barnett PV. Dramatic improvement in FMD DNA vaccine efficacy and cross-serotype antibody induction in pigs following a protein boost. Vaccine 2008, 26, 2647-2656 https://doi.org/10.1016/j.vaccine.2008.01.037
  20. Lin Z, Kato A, Otaki Y, Nakamura T, Sasmaz E, Ueda S. Sequence comparisons of a highly virulent infectious bursal disease virus prevalent in Japan. Avian Dis 1993, 37, 315-323 https://doi.org/10.2307/1591655
  21. Lillehoj HS, Ding X, Quiroz MA, Bevensee E, Lillehoj EP. Resistance to intestinal coccidiosis following DNA immunization with the cloned 3-1E Eimeria gene plus IL-2, IL-15, and IFN-gamma. Avian Dis 2005, 49, 112-117 https://doi.org/10.1637/7249-073004R
  22. Long JE, Huang LN, Qin ZQ, Wang WY, Qu D. IFNgamma increases efficiency of DNA vaccine in protecting ducks against infection. World J Gastroenterol 2005, 11, 4967-4973 https://doi.org/10.3748/wjg.v11.i32.4967
  23. Lukert PD, Saif YM. Infectious bursal disease. In: Saif YM, Barnes HJ, Fadly AM, Glisson JR, McDougald LR, Swayne DE (eds.). Diseases of Poultry. pp. 161-179, Iowa State University Press, Ames, 2003
  24. Mahmood MS, Siddique M, Hussain I, Khan A, Mansoor MK. Protection capability of recombinant plasmid DNA vaccine containing VP2 gene of very virulent infectious bursal disease virus in chickens adjuvanted with CpG oligodeoxynucleotide. Vaccine 2006, 24, 4838-4846 https://doi.org/10.1016/j.vaccine.2006.03.016
  25. Min W, Lillehoj HS, Burnside J, Weining KC, Staeheli P, Zhu JJ. Adjuvant effects of IL-1beta, IL-2, IL-8, IL-15, IFN-alpha, IFN-gamma TGF-beta4 and lymphotactin on DNA vaccination against Eimeria acervulina. Vaccine 2001, 20, 267-274 https://doi.org/10.1016/S0264-410X(01)00270-5
  26. Murphy FA, Fauquet CM, Bishop DHL, Ghabrial SA, Jarvis AW, Martelli GP, Mayo MA, Summers MD. Virus Taxonomy: Sixth Report of the International Committee on Taxonomy of Viruses. pp. 240-244, Springer-Verlag, Wien, 1995
  27. Mundt E, Beyer J, M$\ddot{u}$ller H. Identification of a novel viral protein in infectious bursal disease virus-infected cells. J Gen Virol 1995, 76, 437-443 https://doi.org/10.1099/0022-1317-76-2-437
  28. Negash T, al-Garib SO, Gruys E. Comparison of in ovo and post-hatch vaccination with particular reference to infectious bursal disease. A review. Vet Q 2004, 26, 76-87 https://doi.org/10.1080/01652176.2004.9695170
  29. Oshop GL, Elankumaran S, Heckert RA. DNA vaccination in the avian. Vet Immunol Immunopathol 2002, 89, 1-12 https://doi.org/10.1016/S0165-2427(02)00189-7
  30. Ramshaw IA, Ramsay AJ. The prime-boost strategy: exciting prospects for improved vaccination. Immunol Today 2000, 21, 163-165 https://doi.org/10.1016/S0167-5699(00)01612-1
  31. Rautenschlein S, Yeh HY, Sharma JM. The role of T cells in protection by an inactivated infectious bursal disease virus vaccine. Vet Immunol Immunopathol 2002, 89, 159-167 https://doi.org/10.1016/S0165-2427(02)00202-7
  32. Roh HJ, Sung HW, Kwon HM. Effects of DDA, CpG-ODN, and plasmid-encoded chicken IFN-$\gamma$ on protective immunity by a DNA vaccine against IBDV in Chickens. J Vet Sci 2006, 7, 361-368 https://doi.org/10.4142/jvs.2006.7.4.361
  33. Sharma JM. Introduction to poultry vaccines and immunity. Adv Vet Med 1999, 41, 481-494 https://doi.org/10.1016/S0065-3519(99)80036-6
  34. Snyder DB, Vakharia VN, Savage PK. Naturally occurringneutralizing monoclonal antibody escape variants define the epidemiology of infectious bursal disease viruses in the United States. Arch Virol 1992, 127, 89-101 https://doi.org/10.1007/BF01309577
  35. Stepaniak JA, Shuster JE, Hu W, Sundick RS. Production and in vitro characterization of recombinant chicken interleukin-2. J Interferon Cytokine Res 1999, 19, 515-526 https://doi.org/10.1089/107999099313965
  36. Sundick RS, Gill-Dixon C. A cloned chicken lymphokine homologous to both mammalian IL-2 and IL-15. J Immunol 1997, 159, 720-725
  37. Tarpey I, van Loon AA, de Haas N, Davis PJ, Orbell S, Cavanagh D, Britton P, Casais R, Sondermeijer P, Sundick R. A recombinant turkey herpesvirus expressing chicken interleukin-2 increases the protection provided by in ovo vaccination with infectious bursal disease and infectious bronchitis virus. Vaccine 2007, 25, 8529-8535 https://doi.org/10.1016/j.vaccine.2007.10.006
  38. Tsukamoto K, Tanimura N, Kakita S, Ota K, Mase M, Imai K, Hihara H. Efficacy of three live vaccines against highly virulent infectious bursal disease virus in chickens with or without maternal antibodies. Avian Dis 1995, 39, 218-229 https://doi.org/10.2307/1591863
  39. Van den Berg TP, Gonze M, Meulemans G. Acute infectious bursal disease in poultry: Isolation and characterisation of a highly virulent strain. Avian Pathol 1991, 20, 133-143 https://doi.org/10.1080/03079459108418748
  40. Yeh HY, Rautenschlein S, Sharma JM. Protective immunity against infectious bursal disease virus in chickens in the absence of virus-specific antibodies. Vet Immunol Immunopathol 2002, 89, 149-158 https://doi.org/10.1016/S0165-2427(02)00206-4

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