Incidence and clinical characteristics of thyroid cancer in Korea

우리나라 갑상선암의 발생 현황 및 특징

Ahn, Hwa-Young;Park, Young-Joo
안화영;박영주

  • Published : 20091100

Abstract

The incidence of thyroid cancer is steadily increasing in many countries including Korea. Especially in Korea, the incidence of thyroid cancer is very rapidly increasing during several decades;from 2005 Annual Report of the Korea Center Cancer Registry, thyroid cancer ranked the fifth among all cancers (incidence rate was 8.9%). Moreover the incidence of thyroid cancer was 16.7% in female and now thyroid cancer was reported the most common cancer in Korean female. Among several thyroid cancers, papillary thyroid cancer (PTC) is rapidly increasing due to the increased detection of papillary thyroid microcarcinoma (PMC). Until now, PMC showed little significant differences among clinical characteristics or prognosis compared with PTC, thus the optimal treatment strategy of PMC remains controversial. Therefore, to establish the optimal treatment and follow up program about thyroid cancer, we should investigate clinical characteristics, prognosis and predictive factors of PMC more closely.

Keywords

References

  1. Liu S, Semenciw R, Ugnat AM, Mao Y. Increasing thyroid cancer incidence in Canada, 1970-1996: time trends and age-period-cohort effects. Br J Cancer 85:1335-1339, 2001 https://doi.org/10.1054/bjoc.2001.2061
  2. Kilfoy BA, Zheng T, Holford TR, Han X, Ward MH, Sjodin A, Zhang Y, Bai Y, Zhu C, Guo GL, Rothman N. International patterns and trends in thyroid cancer incidence, 1973-2002. Cancer Causes Control 20:525-531, 2009 https://doi.org/10.1007/s10552-008-9260-4
  3. Leenhardt L, Grosclaude P, Cherie-Challine L. Increased incidence of thyroid carcinoma in france: a true epidemic or thyroid nodule management effects? Report from the French Thyroid Cancer Committee. Thyroid 14:1056-1060, 2004 https://doi.org/10.1089/thy.2004.14.1056
  4. Reynolds RM, Weir J, Stockton DL, Brewster DH, Sandeep TC, Strachan MW. Changing trends in incidence and mortality of thyroid cancer in Scotland. Clin Endocrinol 62:156-162, 2005 https://doi.org/10.1111/j.1365-2265.2004.02187.x
  5. Davies L, Welch HG. Increasing incidence of thyroid cancer in the United States, 1973-2002. JAMA 295:2164-2167, 2006 https://doi.org/10.1001/jama.295.18.2164
  6. 국가암등록사업 연례 보고서 (2005년 암발생, 1993${\sim}$2005년 암생존 현황). 2008
  7. Kim KH, Kang DW, Kim SH, Seong IO, Kang DY. Mutations of the BRAF gene in papillary thyroid carcinoma in a Korean population. Yonsei Med J 45:818-821, 2004 https://doi.org/10.3349/ymj.2004.45.5.818
  8. Tan GH, Gharib H. Thyroid incidentalomas: management approaches to nonpalpable nodules discovered incidentally on thyroid imaging. Ann Intern Med 126:226-231, 1997 https://doi.org/10.7326/0003-4819-126-3-199702010-00009
  9. Dean DS, Gharib H. Epidemiology of thyroid nodules. Best Pract Res Clin Endocrinol Metab 22:901-911, 2008 https://doi.org/10.1016/j.beem.2008.09.019
  10. Papini E, Guglielmi R, Bianchini A, Crescenzi A, Taccogna S, Nardi F, Panunzi C, Rinaldi R, Toscano V, Pacella CM. Risk of malignancy in nonpalpable thyroid nodules: predictive value of ultrasound and color-Doppler features. J Clin Endocrinol Metab 87:1941-1946, 2002 https://doi.org/10.1210/jc.87.5.1941
  11. Hagag P, Strauss S, Weiss M. Role of ultrasound-guided fine-needle aspiration biopsy in evaluation of nonpalpable thyroid nodules. Thyroid 8:989-995, 1998 https://doi.org/10.1089/thy.1998.8.989
  12. 석지혜, 김태용, 김미경, 김원배, 김홍규, 전성훈, 송영기. 갑상선 질환의 기왕력이 없는 성인에서 갑상선 초음파 선별검사로 발견된 갑상선 결절의 유병률. 대한내분비학회지 21:389-393, 2006
  13. 김원준, 김주형, 박동원, 이창범, 박용수, 김동선, 최웅환, 김태화, 안유헌. 건강검진 수진 성인에서 초음파로 발견된 갑상선 결절 유병률과 미세침흡인세포검사 결과. 대한내분비학회지 23:413-419, 2008
  14. Nam-Goong IS, Kim HY, Gong G, Lee HK, Hong SJ, Kim WB, Shong YK. Ultrasonography-guided fine-needle aspiration of thyroid incidentaloma: correlation with pathological findings. Clin Endocrinol 60:21-28, 2004 https://doi.org/10.1046/j.1365-2265.2003.01912.x
  15. 이승훈, 김태용, 류진숙, 공경엽, 김원배, 김성철, 홍석준, 송영기. 1개 병원 갑상선 암환자 특성의 추이 분석. 대한내분비학회지 23:35-43, 2008
  16. Lee J, Rhee Y, Lee S, Ahn CW, Cha BS, Kim KR, Lee HC, Kim SI, Park CS, Lim SK. Frequent, aggressive behaviors of thyroid microcarcinomas in Korean patients. Endocr J 53:627-632, 2006 https://doi.org/10.1507/endocrj.K06-013
  17. Park YJ, Kim YA, Lee YJ, Kim SH, Park SY, Kim KW, Chung JK, Youn YK, Kim KH, Park DJ, Cho BY. Papillary microcarcimom in comparison with larger papillary thyroid carcinoma in BRAF (V600E) mutation, clinicopathological features, and immunohistochemical findings. Head Neck 2009 [Epub ahead of print]
  18. Xing M. BRAF mutation in thyroid cancer. Endocr Relat Cancer 12:245-262, 2005 https://doi.org/10.1677/erc.1.0978
  19. Xing M, Westra WH, Tufano RP, Cohen Y, Rosenbaum E, Rhoden KJ, Carson KA, Vasko V, Larin A, Tallini G, Tolaney S, Holt EH, Hui P, Umbricht CB, Basaria S, Ewertz M, Tufaro AP, Califano JA, Ringel MD, Zeiger MA, Sidransky D, Ladenson PW. BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancer. J Clin Endocrinol Metab 90:6373-6379, 2005 https://doi.org/10.1210/jc.2005-0987
  20. Jo YS, Li S, Song JH, Kwon KH, Lee JC, Rha SY, Lee HJ, Sul JY, Kweon GR, Ro HK, Kim JM, Shong M. Influence of the BRAF V600E mutation on expression of vascular endothelial growth factor in papillary thyroid cancer. J Clin Endocrinol Metab 91:3667-3670, 2006 https://doi.org/10.1210/jc.2005-2836
  21. Lee JH, Lee ES, Kim YS, Won NH, Chae YS. BRAF mutation and AKAP9 expression in sporadic papillary thyroid carcinomas. Pathology 38:201-204, 2006 https://doi.org/10.1080/00313020600696264
  22. Kim TY, Kim WB, Song JY, Rhee YS, Gong G, Cho YM, Kim SY, Kim SC, Hong SJ, Shong YK. The BRAF mutation is not associated with poor prognostic factors in Korean patients with conventional papillary thyroid microcarcinoma. Clin Endocrinol 63:588-593, 2005 https://doi.org/10.1111/j.1365-2265.2005.02389.x
  23. Kim TY, Kim WB, Rhee YS, Song JY, Kim JM, Gong G, Lee S, Kim SY, Kim SC, Hong SJ, Shong YK. The BRAF mutation is useful for prediction of clinical recurrence in low-risk patients with conventional papillary thyroid carcinoma. Clin Endocrinol 65:364-368, 2006 https://doi.org/10.1111/j.1365-2265.2006.02605.x