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The Association of Asthma and Osteoporosis in the Residents of the Local Community

지역사회 주민을 대상으로 한 천식과 골다공증과의 연관성

  • Park, Kyung-Yong (Department of Preventive Medicine, School of Medicine, Chungnam National University School of Medicine) ;
  • Lee, Sok-Goo (Department of Preventive Medicine, School of Medicine, Chungnam National University School of Medicine)
  • 박경용 (충남대학교 의학전문대학원 예방의학과교실) ;
  • 이석구 (충남대학교 의학전문대학원 예방의학과교실)
  • Published : 2009.12.31

Abstract

Objectives: Corticosteroids, usually as an inhaled form, are usually used to treat narrowed airway in the treatment of asthma. However, the use of corticosteroid commonly associated with the development of osteoporosis. In this study, we studied the association of asthma and osteoporosis in the residents of the local community. Methods: As a part of the Local Community Health Study Chungnam 2008, the residents are surveyed with the formal questionnaire. We analyzed the association between asthma and osteoporosis data with the questionnaire. Results: We analyzed total 6,348 data from the residents in Chungnam province. Of them, 203(3.2%) were asthma patients and 465(7.3%) were osteoporosis patients. Patients with asthma have more advanced age(p<0.001), higher incidence of hypertension(p<0.001) and diabetes(p=0.001), lower incidence of exercise(p=0.002) and economic activity(p<0.001). Patients with osteoporosis have more advanced age (p<0.001), female predominance(p<0.001), higher incidence of hypertension (p<0.001), diabetes(p=0.001), and fractures (p<0.001), lower incidence of exercise (p=0.002) and economic activity (p<0.001). In total population, asthma is associated with the increased incidence of osteoporosis, especially in patients treated with anti-asthmatic medications. Conclusions: Through this study, we demonstrated the presence of asthma is closely associated with the increased incidence of osteoporosis, especially in patients treated with anti-asthmatic medications. Therefore, further and broad study will be needed to evaluate the association of asthma and the types of anti-asthmatic medications in the development of osteoporosis.

본 연구는 천식과 골다공증유병유무와의 관련성을 알아봄으로써 골다공증의 예방 및 관리의 기초 자료로 제공하기 위해 시도되었다. 연구의 기초 자료는 ‘2008년 지역사회건강조사’ 를 이용하였다. 조사 시기는 2008년 9월부터 2008년 11월 까지였고, 충남의 7개 군 및 대전시 서구에 거주하는 19세 이상 주민 6,348명을 대상으로 하였다. 이 중 천식이 있다고 응답한 203명 및 골다공증이 있다고 대답한 465명의 특성을 질병이 없는 군의 특성과 비교하였다. 천식 유병유무와 골다공증 유병유무와는 유의한 상관관계가 있었고, 천식대상자 중에서 천식치료여부와 골다공증 유병유무와도 유의한 상관관계가 있었다. 추가로 좀 더 광범위한 연구 분석과 추적조사가 필요하리라 사료된다.

Keywords

References

  1. Osteoporosis prevention, diagnosis and therapy. Jama 2001;285:785-795 https://doi.org/10.1001/jama.285.6.785
  2. Kado DM, Browner WS, Blackwell T, Gore R, Cumming SR. Rate of bone loss is associated with mortality in older women: a prospective study. J Bone Miner Res 2000;15:1974-1980 https://doi.org/10.1359/jbmr.2000.15.10.1974
  3. Chun BY, Kam S, Lee YJ, Lee SW, Lee KE, Lee YS, Kim BK. Therapeutic compliance for calcium supplements and its related factors in rural osteoporotic women. Korean J Rural Med 2001;26(2):111-132(Korean)
  4. Kanis JA, MaCloskey EV. Risk factors in osteoporosis. Maturitas 1998;30:229-233 https://doi.org/10.1016/S0378-5122(98)00090-5
  5. Delmas PD. How should the risk of fracture in postmenopausal women be assessed? Osteoporosis Intern 1999;2;S:33-39
  6. Rideout CA, McKay HA, Barr SI. Self-reported lifetime physical activity and areal bone mineral density in healthy postmenopausal women: the importance of teenage activity. Calcifi Tissue Int 2006;79(4):214-222 https://doi.org/10.1007/s00223-006-0058-7
  7. Rizzoli R, Bonjour JP, Ferrai SL. Osteoporosis, genetics and hormones. J mol Endocrinol 2001;26:79-94 https://doi.org/10.1677/jme.0.0260079
  8. Dawson-Hughes B, Dalal GE, Krall EA, Sadowski L, Sahyoun N, Tannenbaum S. A controlled trial of the effect of calcium supplementation on bone density in postmenopausal women. N Eng J Med 1990;323:178-183
  9. Van Staa TP, Leufkens HG, Cooper C. The epidemiology of corticosteroid-induced osteoporosis: a meta-analysis. Osteoporos Int 2002;13(10):777-787 https://doi.org/10.1007/s001980200108
  10. Yu MA. Analysis on management status of glucocorticoid-induced osteoporosis in patients with rheumatoid arthritis. Graduate School of Ewha Womans University, 2004(Korean)
  11. 질병관리본부. 지역사회건강조사. 2008
  12. Lee UJ. The relationship of bone density and eating habits/nutritional intake in adult females. Graduate school of education, Keimyung University, 2006(Korean)
  13. Oh SI, Lee HS, Lee MS, Kim CI, Kwon IS. Factors affecting bone mineral status of premenopausal women. Korean J Community Nutrition 2003;8(6):927-937(Korean)
  14. Bae SW, Nam CH, Hong SC, Choi YH, Lee JO, Yang SH. Physical activity, life-style related to bone mineral density in pre- and postmenopausal women. J Korean Public Health Assoc 2002;28(3):259-271(Korean)
  15. Felson DT, Zhang Y, Hannan MT, Kiel DP. Alcohol intake and bone mineral density in elderly men and women. Am J Epidemiol 1995;142:485-492 https://doi.org/10.1093/oxfordjournals.aje.a117664
  16. Hansen MA, Overgaard K, Riis BJ, Christiansen C. Potential risk factors for development of postmenopausal osteoporosisexamined over a 12-year period. Osteoporosis Int 1991;1:95-102 https://doi.org/10.1007/BF01880450
  17. Holbrook TL, Barrett-Connor E. A prospective study of alcohol consumption and bone mineral density. BMJ 1993;306:1506-1509 https://doi.org/10.1136/bmj.306.6891.1506
  18. Wild RA, Buchanan JR, Myers C, Demers LM. Declining adrenal androgens: an association with bone loss in aging women. Proc Soc Exp Biol Med 1987;186:355-360 https://doi.org/10.3181/00379727-186-42625
  19. Baron JA, Farahmand BY, Weiderpass E. Cigarette smoking, alcohol consumption, and risk of hip fracture in women. Arch Intern Med 2001;161:893-898 https://doi.org/10.1001/archinte.161.6.893
  20. Arnulf LM, Siri FM, Solfrid LL, Roar JS, Leif BM. Effect of inhaled corticosteroids on forearm bone mineral density: The HUNT Study, Norway. Rep. Med 2007;101:1744-1752 https://doi.org/10.1016/j.rmed.2007.02.018
  21. Suissa S, Baltzan M, Kremer R, Ernst P. Inhalted and nasal corticosteroid use and the risk of fracture. Am J respir Crit Care Med 2004;169(1):83-88 https://doi.org/10.1164/rccm.200305-640OC
  22. Hubbard RB, Smith CJ, Smeeth L, Harrison TW, Tattersfield AE. Inhaled corticosteroids and hip fracture: a population-based case-control study. Am J Respir Crit Care Med 2002;166(12, Part 1):1563-1566 https://doi.org/10.1164/rccm.200206-606OC
  23. Leone FT, Fish JE, Szefler SJ, West SL, Systematic review of the evidence regarding potential complications of inhaled corticosteroid use in asthma: collaboration of American College of Chest Physicians, American Academy of Allergy, Asthma, and Immunology, and American College of Allergy, Asthma, and Immunology. Chest 2003;124(6):2329-2340 https://doi.org/10.1378/chest.124.6.2329
  24. Global Initiative for Asthma, Global Strategy for asthma management and revention NHLBI/WHO workshop. National Heart, Lung, and Blood Institute, National institutes of Health, Bethesda, MD (US-DHHS/PHS/NIH Publication No.02-3659), 2002 April
  25. 최인선. 천식의 스테로이드 흡입치료. 대한내과학회지 2001;61(1):3-9

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